background of the notch pathway in cancer

Báo cáo y học: "The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies" pdf

Ngày tải lên : 12/08/2014, 15:22

... Activation of the Notch pathway The ﬁrst described Notch activation cascade consists of a series of cleavages leading to the release of the intracellular domain of the receptor, which interacts in the ... ligand-receptor interaction and a cysteine rich region The intracellular domain consists of ankyrin repeats, a glutamine-rich domain and a PEST (proline, glutamate, serine, threonine) domain [14,15] The Notch ... control of the two signaling pathways [39,40] The two Notch signaling pathways may interact in concert or in a coordinated manner to provide the necessary regulation of nuclear genes encoding cytoskeletal...

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Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells doc

Ngày tải lên : 16/03/2014, 16:20

... or by the inhibitory Smad7 protein To assess the involvement of TrkA receptors in the activation of the Smad pathway, different TrkA variants were tested in reporter gene assays using the pSBE-luc ... mediates the activation of the Smad pathway independently of the TGF-b ligand Fig PC12 cells express low levels of endogenous TbRII (A) C-terminal phosphorylation of Smad2 was investigated in either ... Referring to Smad4, there are signiﬁcant levels of protein in the nucleus of both cell lines already in the absence of ligand Cycloheximide treatment for h prior to the addition of NGF indicated that...

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Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot

Ngày tải lên : 23/03/2014, 13:20

... extreme modulations of enzyme activities In particular, in the combinations involving the decrease of glyoxalase II activity the effect is equivalent to the modulation of the other parameters alone, ... metabolites in Leishmania infantum promastigotes (A) Analysis of 2-oxoaldehydes, showing the presence of MG as 2-methylquinoxaline and the internal standard (IS, lM 2,3-dimethylquinoxaline) Other peaks ... quantitative analysis of the most critical parameters of the pathway regarding this goal requires the knowledge of the intracellular concentrations of all metabolites involved and a kinetic model that...

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báo cáo hóa học:" Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ-responsive genes" pptx

Ngày tải lên : 18/06/2014, 15:20

... among the training set, suggesting clear distinction between the two subgroups The rest of the glioma samples were then subjected to SVM as the test set Table summarized the results of the SVM ... glial tumors (the Freije dataset) shown in box plots Y-axis is the expression level of SERPINE1 in log2 scale The black arrow indicates the mean expression level of SERPINE1 in each type of gliomas ... region of the SERPINE1 gene [32,33] The protein products of the SERPINE1 gene play important roles in TGFβ-mediated biological processes such as fibrosis and wound healing [34] The induction of SERPINE1...

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báo cáo khoa học: " Activation of the hedgehog pathway in chronic myelogeneous leukemia patients" ppt

Ngày tải lên : 10/08/2014, 10:20

... activating point mutations of Smo or inactivating point mutations in Ptch1 or SUFU [8-12] Although inappropriate activation of the Hh signaling pathway has been shown in many cancers, the assessment ... assessment of the contribution of Hh signaling pathway has not been thoroughly examined in hematologic malignancies Given the parallels in Hh signaling between regulation of proliferation of primitive ... understand the biological function(s) of IFNa in the Hh pathway In conclusion, we confirmed variable abnormalities of Hedgehog pathway activation in CML cases involved in this study, raising a possibility...

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Báo cáo khoa học: A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin pptx

Ngày tải lên : 23/03/2014, 13:20

... produced in the skin The level of 7-DHP production and its hypothetical conversion into other metabolites (including 17-, 20-, 21- and 11-hydroxy-7DHP) are the subject of investigations in our ... 7-DHC; the retention time for its ion with m/z 385.3 and UV spectra are shown in the inset in (B) and in inset in (D) These results are in agreement with recent ﬁndings of Thiboutot et al [36] of ... C) The product was at the limits of detectability in the control sample with the reaction stopped at time (A) and in mitochondria incubated in the absence of NADPH and isocitrate (B and E) The...

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Báo cáo khoa học: Deviation of the neurosporaxanthin pathway towards b-carotene biosynthesis in Fusarium fujikuroi by a point mutation in the phytoene desaturase gene ppt

Ngày tải lên : 30/03/2014, 01:20

... transformation of the SF1 strain with a plasmid carrying carB36 In ﬁve of them, Southern blot analyses showed the incorporation of a single copy of the plasmid at the carB locus (Fig 4A,B) Three of these ... crassa coincides with that of F fujikuroi in the synthesis of the same end-product, the apocarotenoid neurosporaxanthin, but both fungi differ in the order of the reactions Whereas in N crassa the ... resulting in a Trp449 ﬁ Stop mutation The predicted truncated protein lacks the C-terminal 121 4588 amino acids, which include the putative carotene-binding domain [37], making the accumulation of...

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Báo cáo khoa học: Probing the access of protons to the K pathway in the Paracoccus denitriﬁcans cytochrome c oxidase pdf

Ngày tải lên : 30/03/2014, 15:20

... the kinetics of reduction of this mutant were investigated by stopped-flow spectrophotometry by anaerobically mixing a degassed sample of the mutant in the oxidized state with a large excess of ... different kinetic properties In the case of the Paracoccus wild-type enzyme, the observed fitted rate constant relative to the major kinetic phase ( 19 s)1 corresponding to 70% of the reaction ... carboxylic groups and the modes at 1556 and 1402 cm)1 from the m(COO–)s ⁄ as vibrational modes of the corresponding deprotonated form The relation of the extinction coefficients of these modes are close...

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báo cáo hóa học: " Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment" ppt

Ngày tải lên : 18/06/2014, 19:20

... evaluated using a statistical indicator, the standardized response mean (SRM) The SRM is the change in score divided by the standard deviation of the change in score It is independent of sample ... (improvements) in the subgroups reporting improvements on global health Accordingly, only a minor change on the EQ VAS and no change on the EQ-5D Index were reported in the no change subgroup of the EORTC ... examine responsiveness, SRMs were calculated for the EQ-5D Index and EQ VAS (table 2) In the subgroup of patients whose global health had not changed, accordingly, neither the SRM of the EQ-5D Index,...

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present and future of the cosmic microwave background proceedings of the workshop held in santander spain 28 june-1 july 1993

Ngày tải lên : 03/07/2014, 21:10

... three kinds of distorted spectra and for several choices of the redshift of heating, zh, i.e for the corrisponding value of y~ indicated in the top panel In the two first cases the energy is injected ... Ae/e) includes the effect of relativistic neutrinos on the expansion time in presence of energy injected in the radiation field (for species of massless neutrinos, ~ = 1.68) On the other hand the ... factor of in the determination of a,y,,, above 408 MHz and by a factor of in the absolute calibration of the Haslam m a p would greatly enhance the quality of our results The sanle data obtained in...

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Báo cáo khoa học: "Thyroid cancer causing obstruction of the great veins in the neck" ppt

Ngày tải lên : 09/08/2014, 07:21

... most of the associated venous complex in the upper neck extending up the common facial vein at the margin of the mandible Tumour extended into the lumen of the deep lingual vein and other veins ... suggestive of residual tumour in the SVC 2b Post radioiodine therapy scan showing a focus of intense 131I accumulation in the right upper mediastinum suggesting tumour at the root of the SVC Marked ... operability The scans showed a mass arising in the left lobe of the thyroid extending to the superior mediastinum Multiple lymph nodes were visualized in the left cervical chain encasing the carotid...

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Báo cáo khoa học: "Correction: Thyroid cancer causing obstruction of the great veins in the neck" pps

Ngày tải lên : 09/08/2014, 07:21

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Báo cáo khoa học: "Tangential beam IMRT versus tangential beam 3D-CRT of the chest wall in postmastectomy breast cancer patients: A dosimetric comparison" docx

Ngày tải lên : 09/08/2014, 09:20

... beams of the corresponding IMRT plan The PTV included the same PTV used for the 3D-CRT plans plus an extension into the air anteriorly of the chest of 1.5 cm to ensure appropriate opening of the ... excluded in the target volume of the whole breast, whereas these structures are included in the target volume of the chest wall Due to these differences in the target volume, results of a dosimetric ... breast in early breast cancer patients Data about the impact of IMRT on the adjuvant radiotherapy of the chest wall in postmastectomy patients are scarce in the literature There are distinct geometric...

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Báo cáo khoa học: "The prognostic value of the nodal ratio in N1 breast cancer" pps

Ngày tải lên : 09/08/2014, 09:21

... presence of lymphovascular invasion (LVI), and resection margin status A close margin was defined as the presence of invasive carcinoma within mm of the surgical margin of resection Patient grouping ... one of the most important factors affecting prognosis in patients with breast cancer [1] According to the current 7th edition of the American Joint Committee on Cancer staging system, N stage in ... prescribed The tumor characteristics in the two groups are summarized in Table Infiltrating ductal carcinoma was the most frequent tumor histology in both groups, but was more dominant in the LNR...

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Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps

Ngày tải lên : 09/08/2014, 10:20

... important activators of the JNK pathway in FLSs In the present study, we examined the hierarchy of these proteins in IL-1β-mediated JNK activation in RA FLSs using siRNA The results showed that ... between interleukin-8 and interleukin-1beta Arthritis Rheum 2004, 50:1437-1447 Shin M, Yan C, Boyd D: An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding ... 146:3365-3371 Vincenti MP, Brinckerhoff CE: Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific...

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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

Ngày tải lên : 09/08/2014, 10:21

... both in monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding ... and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative of the sizes/distances in the gene/protein) cases combined (P-value ... variation in the ATM gene where combined into one group The level of adverse side effects in the Norwegian breast cancer patients or risk of IBTR in the American breast cancer cases were then Page of...

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The role of cholesterol sequestration and accumulation in the endocytic pathway in development of neurodegenerative diseases

Ngày tải lên : 14/09/2015, 14:06

... forskolin have effects on the endocytic trafficking via regulation of the expression of Rab GTPase, and may provide insight into the mechanism of the molecular basis of neurodegeneration in NPC1 ... referred to as the NPC1 domain Within NPC1 there is a large, cysteine-rich luminal loop (amino acids 855–1098), which contains a ring-finger motif that may mediate protein– protein interactions ... carboxyl-terminal dileucine motif that is required for proper targeting of the protein to the endocytic pathway (Watari et al 1999) ) Studies of the subcellular distribution of NPC1 localize the protein...

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Apprenticeships in York - a presentation developed as part of an IAG package raising the profile of the apprenticeship pathway

Ngày tải lên : 05/12/2016, 21:14

... Apprenticeships in York area These are: Babcock Training CITB ConstructionSkills JHP Training YH Training Services York College York Training Centre These are the main Training Providers but there are ... for higher level skills •Combine a range of on and off the job training •Will vary in time to complete depending on your role and need of your employer •Usually include a HNC/HND, NVQ Level and ... Management The Local Picture In York the following frameworks are currently available: •Accounting (YH Training Services and York College) •Business Administration (JHP Training) •Children & Young...

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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"

Ngày tải lên : 25/10/2012, 11:04

... pneumatization results in the individual size and shape of the frontal sinus An absence of pneumatization in the frontal bone results in frontal sinus aplasia [1] This kind of variation should make ... both sinuses may be absent The prominence of supercilliary arcs does not indicate the absence, presence or size of the frontal sinus [3] The objective of this study was to investigate the prevalence ... the patients’ mid-sagittal lines, which helped to keep the head centered with respect to the rotational axis The lateral positioning light was centered at the level of the sinus, indicating the...

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Tiểu luận tiếng anh : Robinson Crusoe – A Representative of the English Bourgeoisie in the early 18th century

Ngày tải lên : 26/11/2012, 12:02

... Obviously, the bourgeoisie was the driving force of the English society at that time They thought they had rights to be proud of their status in society and in the superiority of their race They wanted ... a common saying that ” The sun never sets in the Great Britain” The 18th century is known in the history of European culture as the period of Enlightenment In England the period of Enlightenment ... wood-making industries They had to join the force of cheap labor and working in such factories England became a typical example of initial accumulation of capitalism Holding power in economics, the...

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