a role for antisense technology in the discovery of highly specific and versatile signal transduction inhibitors

Báo cáo y học: "Genomic neighborhoods for Arabidopsis retrotransposons: a role for targeted integration in the distribution of the Metaviridae" docx

Ngày tải lên : 14/08/2014, 14:21

... element abundance in A thaliana Wright et al [33] examined recombination rate relative to element abundance in detail and found that the abundance of most A thaliana TE families actually had a small ... RetroMap-generated datafile was used as the data source for statistical testing The data file contains chromosomal element coordinates, LTR identity, age and lineage information for all A thaliana ... tested The Athila elements are large, and our underestimate of the number of Athila elements resulted in a corresponding underestimate of the total amount of retrotransposon DNA in the A thaliana...

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Báo cáo hóa học: "A framework for ABFT techniques in the design of fault-tolerant computing systems" pot

Ngày tải lên : 20/06/2014, 22:20

... syndromes and comparing against thresholds five times the standard deviation of syndrome values when only low levels of round-off error appear The simulation program randomly selects the line in a magnitude ... blocks of data over a wide range of variances are performed For the Figure Detection performance of the comparator versus threshold Hamidi et al EURASIP Journal on Advances in Signal Processing ... samples Burst and errors within each block are permitted A burst in this context means that the standard deviations of all components in a block are raised to 10% of the maximum standard deviation...

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Báo cáo khoa học: "Is there a place for N-acetylcysteine in the treatment of septic shock" pptx

Ngày tải lên : 12/08/2014, 20:20

... microcirculation and thus oxygen extraction, while at the same time attenuating inflammatory responses Prostacyclin, a prostaglandin synthesized in endothelial cells, is a potent vasodilator and an inhibitor ... groups The number of days of acute lung injury was decreased, however, and there was also a significant increase in the cardiac index in the NAC-treated group [20] Conclusions This is an exciting ... the sample size was small in the extended case report [1], Hein and colleagues have made a significant contribution to our understanding of the important role of antioxidant agents such as NAC...

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Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot

Ngày tải lên : 07/03/2014, 06:20

... meprin Non-activated meprin In total Activated meprin Non-activated meprin In total Activated meprin Non-activated meprin In total Activated meprin Non-activated meprin In total 1 2 3 4 All All All ... database (release 48.8) with fixed carbamidomethyl modification of cysteine residues, variable oxidation of methionine and variable deamidation of asparagine and glutamine Parent and fragment mass ... approach implemented on an astacin family member of metalloendopeptidases On the basis of our findings, hmeprin may be considered as a signalling protease mediating direct and indirect cleavage and...

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Báo cáo khoa học: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components ppt

Ngày tải lên : 07/03/2014, 11:20

... the dramatic effects of the SG knockout on granular staining properties and storage of proteases, it was ﬁrst important to determine whether the lack of SG affected the actual assembly of granules ... b-hexosaminidase is in uenced by SG Although b-hexosaminidase activity was already detected at day 0, the intracellular content of this enzyme increased markedly after days of culture, and reached a ... a plateau of maximal storage seen after 26 days of culture mMCP-6 storage showed similar kinetics as for mMCP-5 In contrast, CPA protein was detected as early as after days of culture, and a...

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Báo cáo khoa học: "A Feedback-Augmented Method for Detecting Errors in the Writing of Learners of English" docx

Ngày tải lên : 23/03/2014, 18:20

... singular and plural Finally, the tagged instances are stored in a ﬁle with their surrounding words Each line of it consists of one of the tagged instances and its surrounding words as in the above ... in training data For simplicity of implementation, they are excluded from training data Note that the tagging rules can be used only for generating training data They cannot be used to distinguish ... taken into account in this paper, the feedback corpus contains further useful information For example, we can obtain training data consisting of instances of errors by comparing the feedback corpus...

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Báo cáo y học: "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANK" pps

Ngày tải lên : 09/08/2014, 06:22

... staining for RANKL in synovial cells and in the infiltrating (inflammatory) cells (Fig 4h) There was a marked increase in RANKL expression, consistent with the increase in inflammatory cells and ... corresponding to amino acids 317–616 mapping at the carboxy terminus of RANK of human origin [H-300]) or against RANKL (rabbit polyclonal antibody raised against the epitope corresponding to amino acids ... pre-osteoclasts and osteoclasts, initiating signal transduction that results in the differentiation of osteoclast progenitors as well as activation of mature osteoclasts, and therefore is implicated in...

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Báo cáo y học: "Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling" pps

Ngày tải lên : 09/08/2014, 10:21

... patellar and tibial cartilage was assessed The cartilage of the patella and the tibia was isolated 3, 7, and 21 days after viral injection and incubated with 35SO42- for hours The proteoglycan synthesis ... visual investigation Therefore, the safranin O staining intensity was scored in patellar and tibial cartilage with a computerized imaging system There was a significant (30%) increase in safranin ... staining intensity in the patella on day When the data of all time points were pooled, a significant increase in safranin O staining was observed The tibial cartilage, however, did not display...

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Báo cáo y học: "A role for prophylactic antibiotics in necrotizing pancreatitis" doc

Ngày tải lên : 13/08/2014, 11:23

... superinfection, and therefore may affect the risk for pancreatic infection Time for a change For all of the above reasons, the beneficial effect of prophylactic antibiotics in the ideal standardized setting ... patient truly at risk for infection and have a treatment modality that has no relevant side effects and that can be initiated in a timely fashion, the role of antibiotics in patients with established ... performed Timely initiation of antibiotics is essential in pancreatic infection, just as in any other (intra-abdominal) infection Therefore, a low threshold for an aggressive diagnostic approach...

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Develop strategy for the Post & Telecommunication institute of technology in the period of 2010 - 2012

Ngày tải lên : 26/03/2015, 10:44

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Development of a novel toll like receptor based two hybrid assay for detecting protein protein interactions and its application in the study of CD14 dimerization and FcyRIIA activation

Ngày tải lên : 12/09/2015, 08:20

... regulators of IRF-3 activation in the MyD88-independent pathway 23 Figure 1.8 TIR domain-containing adaptors and TLR signaling MyD88 is an essential TIR domain-containing adaptor for the induction ... induction of inflammatory cytokines via all the TLRs TIRAP/Mal is a second TIR domain-containing adaptor that specifically mediates the MyD88-dependent pathway via TLR2 and TLR4 In the TLR4 and TLR3mediated ... TAB1, and is essential for IL-1 and TNF-α induced NF-κB activation (Jiang et al., 2002) Interaction of the IRAK4/IRAK1/TRAF6 and TAK1/TAB1/TAB2 complexes induces phosphorylation of TAB2 and TAK1,...

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A study on english acronnym in the name of international organizations

Ngày tải lên : 11/12/2013, 23:48

... Name of international organizations I/ Name of international organizations stand for in different majors Names of military organizations AADC: Area Air Defense Commander AAFES: Army and Air Force ... of Agriculture Names of Educational Organizations AACTE: American Association of Colleges for Teacher Education AAMC: Association of American Medical Colleges AAPSP: American Association of Professional ... Stimulated Emission of Radiation NAFTA: North American Free Trade Area NASA: National Aeronautics and Space Administration NATO: North Atlantic Treaty Organization 31 OPEC: Organization of Petroleum...

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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

Ngày tải lên : 14/02/2014, 19:20

... Department of Biotechnology (Govt of India) for partial ﬁnancial support The authors thank Dinesh Kumar for recording the scanning electron micrographs and Shivcharan Prasad and Pinakin Makwana for ... provide a better understanding of the role of various interacting components The formation of dopamine–quinone adducts (because of auto-oxidation of the neurotransmitter), especially dopaminochrome, ... an important probe for characterization of the nature of the aggregates Characteristic sigmoidal curves of amyloid-type aggregates, Fig Aggregation of a- synuclein (A) Samples were withdrawn after...

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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx

Ngày tải lên : 18/02/2014, 14:20

... PCR ampliﬁcation of cDNAs was performed with the following primers: 5¢-TCTCTGCTGC CAGACA-3¢ and 5¢-GCCACAGCAGAACAGA-3¢ for HVEM; 5¢-TCCTTCACCGATGGCACTATCC-3¢ and 5¢-TCAACACCAGCAGGATGCTC-3¢ for ... nectin-1; and 5¢-AGAAGCAGCAGCACCAGCAG-3¢ and 5¢-GTCACG TTCAGCCAGGA-3¢ for nectin-2 The 3-OST-3 sequences were ampliﬁed using 5¢-CAGGCCATCATCATCGG-3¢ and 5¢-CCGGTCATCTGGTAGAA-3¢ primers RT-PCR analysis ... regions in (b) and (e) are highlighted in (c) and (f) Arrows and arrowheads in (c) and (f) indicate the association of HSV-1 GFP particles with actin-stained rhodamine phalloidin (g, h) Effect of...

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Ngày tải lên : 08/03/2014, 08:20

... sufﬁcient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant rats [39], and that prolonged GSK3 inhibition ... statistical analysis was performed using one-way analysis of variance (ANOVA) followed by a Newman–Keuls post-test Data analysis was performed using GRAPHPAD PRISM software and considered statistically ... phosphatidylinositol 3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the...

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Báo cáo " Using Bloom’s revised taxonomy to design in-class reading questions for intermediate students in the context of Vietnam " ppt

Ngày tải lên : 14/03/2014, 11:20

... presented as hereafter: Remembering: Recalling information Understanding: Explaining ideas or concepts Applying: Using information in another familiar situation Analyzing: Breaking information into parts ... examples, compare and contrast, and classification - Exemplifying, comparing and contrasting, and classifying - Identify the main ideas and organization of the information - Intermediate Skimming, ... provided information (lower-level of cognitive domain, Bo-Linn [1]) and left a large gap on applying, analyzing, synthesizing, evaluating and creating (highlevel of cognitive domain, Bo-Linn [1]) In...

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Philosophy in a New Key A Study in the Symbolism of Reason, Rite, and Art

Ngày tải lên : 14/03/2014, 17:25

... Church Fathers and culminating in the great Scholastics But, at last, its generative ideas—sin and salvation, nature and grace, unity, infinity, and kingdom—had done their work Vast systems of thought ... elaborate 'ape-ways' into which a newcomer is gradually acculturated, including among other patterns ways of using available instruments for reaching and climbing, a sort of rhythmic play or dance, ... in the next season of the human understanding Symbolic Transformation The vitality and energies of the imagination not operate at will; they are fountains, not machinery D G JAMES, Skepticism and...

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THE PART BORNE BY THE DUTCH IN THE DISCOVERY OF AUSTRALIA 1606-1765 pdf

Ngày tải lên : 15/03/2014, 03:20

... Zealand (Staten-land) and certain island-groups east of Australia, but did not touch at or sight the east-coast of Australia Of course, after the discovery of the west-coast of New Zealand and ... Progress of the United Netherlands Chartered East India Company Printed Anno Domini 1646] A Narrative and Journal of the voyage made from Bantam to the coast of Choromandel and other parts of India, ... which they of the islands of Ceran and, Banda carry on trade They can say nothing certain respecting the island of Nova Guinea, but say that there are white people living on the south side, inhabited...

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