4 factors predisposing to brain injury post cardiac surgery

báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc

Ngày tải lên : 19/06/2014, 22:20

... individual cage for at least days prior to injury surgery and during the period after surgery until euthanasia Cryolesion brain injury The cryolesion injury method was adapted from [27] Mice ... point CD3 antibody was used to identify T cells in the injury site (Figure 2C) T cells were found to be mainly confined to the injury site T cell numbers were found to be relatively low at and ... Th1 and Th2 cytokines were assayed to determine if there were systemic differences in the inflammatory response to brain injury Unfortunately most of the cytokines tested were not detectable...

11
460
0

báo cáo khoa học:" Bruxism secondary to brain injury treated with Botulinum toxin-A: a case report" ppt

Ngày tải lên : 11/08/2014, 23:22

... cranio-cervical dystonia, post- anoxic brain damage, coma, cerebellar damage, Huntington's disease, Rett's syndrome, Whipple's disease, mental retardation and exposure to dopamine receptorblocking medications ... diagnosis of global ischemic/hypoxic brain injury was then reached After one month, the patient responsiveness to touch and voice increased, he responded to eye contact and answered questions ... continued to be under the care of the multidisciplinary team Discussion Bruxism after brain injury was first described by PratapChand and Gourie-Devi [8]; the group reported that bruxism in comatose...

3
347
0

Báo cáo y học: "Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial" pps

Ngày tải lên : 13/08/2014, 08:20

... recombinant factor VIIa in head injury: a report of five cases Semin Hematol 2004, 41(1 Suppl 1):175-176 Morenski JD, Tobias JD, Jimenez DF: Recombinant activated factor VII for cerebral injury- induced ... administered in addition to standard treatment for injuries and bleeding at the participating hospitals Traumatic brain injury post hoc subanalysis In accordance with protocol inclusion criteria, ... severity assessment of the head injury in the majority of these patients Therefore, to identify patients with a TBI component of their injury, we were obliged to perform a post hoc subanalysis This...

8
292
0

Báo cáo y học: "Effect of pentoxifylline on preventing acute kidney injury after cardiac surgery by measuring urinary neutrophil gelatinase - associated lipocalin" pps

Ngày tải lên : 10/08/2014, 09:23

... A review of anti-inflammatory strategies in cardiac surgery Perfusion 2003, 18:7-12 16 Chong AJ, Hampton CR, Verrier ED: Microvascular Inflammatory Response in Cardiac Surgery Seminars in Cardiothoracic ... kidney injury (AKI) is a common complication after coronary artery bypass graft • Pentoxifylline tends to reduce UNGAL although not significant • Pentoxifylline can prevent AKI after cardiac surgery ... systemic inflammatory response syndrome (SIRS) Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, inhibits some pro-inflammatory cytokines such as tumor necrosis factor (TNF)-a, interleukin...

6
360
0

Báo cáo khoa học: "Protocolized resuscitation with esophageal Doppler monitoring may improve outcome in post-cardiac surgery patients." ppt

Ngày tải lên : 12/08/2014, 22:22

... protocol or EDM Second, it is not clear if the benefits were due to EDM or the act of protocolizing resuscitation It could be that using a protocolized resuscitation algorithm with other monitoring ... controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery BMJ 2004, 329:258-261 Gan TJ, Soppitt A, Maroof M, el ... Second, compared to the traditional measure of central hemodynamics, the pulmonary artery catheter, EDM is less invasive, it provides continuous ‘beat -to- beat’ cardiac output monitoring, and it...

2
194
0

The relationship of psychological and personality factors to post concussive symptoms (PCS) in mild traumatic brain injury (MTBI) patients

Ngày tải lên : 16/10/2015, 15:38

... to the ICD-10, requires that three or more symptoms last at least three months postinjury or substantial worsening of previously experienced symptoms post -injury to qualify for a diagnosis, together ... two or more symptoms at months post -injury are likely to complain of a similar number 6-12 months post -injury and approximately two thirds of those who have PCS at months post -injury display an ... head injury questionnaire PCS Post- concussive symptoms PTA Post- traumatic amnesia PTSD Post- traumatic stress disorder RAVLT Rey auditory verbal learning test RPQ Rivermead post- concussive symptoms...

131
432
0

báo cáo hóa học: " Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury" pptx

Ngày tải lên : 19/06/2014, 22:20

... Post -Injury (hours) 24 48 72 96 Time Post -Injury (hours) 0.6 0.4 0.2 0.0 Brain IL-10 (pg/mg protein) 0.2 S * S 24 48 72 96 Time Post -Injury (hours) F 0.3 0.0 * * Sham TAI TAI+Hx 0.8 96 Time Post -Injury ... 0.8 96 Time Post -Injury (hours) E * D Brain IL-2 (pg/mg protein) Brain TNF (pg/mg protein) B Time Post -Injury (hours) C Brain IL-4 (pg/mg protein) * Brain IL-1 (pg/mg protein) Brain IL-6 (pg/mg ... in TNF at h post -injury, lasting up to 72 h post -injury These early enhancement in the TAI+Hx rats possibly reflects a more severe brain damage in this combined insult model Similar to IL-1b and...

16
335
0

báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf

Ngày tải lên : 19/06/2014, 22:20

... influenced by inflammatory processes, which can augment primary injury caused by reduced blood supply The cytokines interleukin-1α (IL-1α) and IL-1β are key contributors to ischemic brain injury However, ... inflammatory response Findings Inflammation is recognised as a major contributor to the worsening of acute brain injury [1] In particular two pro-inflammatory members of the IL-1 family of cytokines, ... ischemia the primary injury to brain cells is caused by the lack of blood supply and so can be considered sterile Sterile inflammation is known as a major contributor to disease and injury [14], and...

16
425
0

cáo khoa học: " A knowledge translation collaborative to improve the use of therapeutic hypothermia in post-cardiac arrest patients: protocol for a stepped wedge randomized trial" pdf

Ngày tải lên : 10/08/2014, 10:23

... University of Toronto, Toronto, Canada 9Sunnybrook Research Institute, Sunnybrook Health Sciences Centre; Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada ... anoxic brain injury Current advanced cardiac life-support (ACLS) algorithms for cardiac arrest have traditionally focused on early intensive resuscitation, and options to prevent anoxic brain injury ... Michael’s Hospital, University of Toronto, Toronto, Canada 5Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada 6Interdepartmental...

7
435
0

Textbook of Traumatic Brain Injury - part 4 pdf

Ngày tải lên : 10/08/2014, 18:20

... 15–1 TEXTBOOK OF TRAUMATIC BRAIN INJURY Indicators of mild brain injury Duration of loss of consciousness None to 30 minutes Duration of posttraumatic amnesia Minutes to 24 hours (can be longer) ... TBI The anxiety disorder may be due to the brain injury directly or to the accumulation of severe life experiences that immediately follow the brain injury or to the combination of both events ... anxiety symptoms combined with rituals to reduce symptoms The following case example illustrates somatic consequences of anxiety related to brain injury: Mr B was a 26-year-old motorcycle enthusiast...

64
317
2

Báo cáo khoa học: "SOFA is superior to MOD score for the determination of non-neurologic organ dysfunction in patients with severe traumatic brain injury: a cohort study" doc

Ngày tải lên : 13/08/2014, 02:24

... immune mediator production following traumatic brain injury In Shock, Sepsis, and Organ Failure -Brain Damage Secondary to Hemorrhagic-Traumatic Shock, Sepsis, and Traumatic Brain Injury: Fifth ... head CT (%) Subdural hematoma 54% Extradural hematoma 55% Diffuse axonal injury 31% Intraventricular hemorrhage 32% Parenchymal hematoma 28% Patient characteristics A total of 209 patients were ... Problems of the ESICM Intensive Care Med 1999, 25:686-696 18 Bratton SL, Davis RL: Acute lung injury in isolated traumatic brain injury Neurosurgery 1997, 40:707-712 discussion 712 19 Zimmerman JE, Knaus...

10
388
0

Báo cáo y học: " The costs of traumatic brain injury due to motorcycle accidents in Hanoi, Vietnam" doc

Ngày tải lên : 13/08/2014, 11:22

... According to the World Health Organization, traumatic brain injury (TBI) is the main cause of fatal and non-fatal injury for motorcycle users [1] In poor countries, economic losses caused by TBI due to ... traumatic brain injury from motor vehicle accidents: factors associated with return to work Arch Phys Med Rehabil 1999, 80:392-398 Wagner AK, Hammond FM, Sasser HC, Wiercisiewski D: Return to productive ... serious head injury [4] In Vietnam, a mandatory helmet law was introduced for all roads on 15 December 2007, two years after this study was completed Prior to this, it was mandatory to wear a helmet...

7
406
0

Báo cáo y học: "rogesterone in traumatic brain injury: time to move on to phase III trials" doc

Ngày tải lên : 13/08/2014, 11:22

... networks of investigators working in unison to bring these agents through the various stages necessary from preclinical promise to clinical reality are vital to those of us seeking to expand our armamentarium ... results of phase III trials with progesterone in traumatic brain injury In the meantime, the scientific community needs to continue to pursue similar, early phase trials with other candidate ... injuries [6-8] Competing interests SMM is an investigator in the Traumatic Brain Injury Clinical Trials Network JDK is a Principal Investigator in the Resuscitation Outcomes Consortium References...

2
237
0

Báo cáo y học: " Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury" docx

Ngày tải lên : 13/08/2014, 11:22

... from to mmol/l (90 to 144 mg/dl) to 3.5 to 6.5 mmol/l (63 to 117 mg/dl) at our institution, with the aim being to reduce cellular insults related to high blood glucose levels and concomitantly to ... traumatic brain injury (TBI) subjected to two different blood glucose targets: 3.5 to 6.5 mmol/l versus to mmol/l AIS, abbreviated injury score; CT, computed tomography; EDH, epidural haematoma; ... between 3.5 to 6.5 mmol/l versus to mmol/l (Figure 1) Propensity-matched patients To increase comparability between patients who were treated sequentially (2000 to 2002 and 2002 to 2004) with...

13
393
0

Báo cáo y học: "Optimizing cerebral glucose in severe traumatic brain injury: still some way to go" pdf

Ngày tải lên : 13/08/2014, 16:20

... levels below mmol/l, and levels of to mmol/l appear to be beneficial in improving metabolic stability [10-12] Clearly, further work needs to be undertaken to confirm or reject these theories, ... Sommerfeld J, Cottini SR, Keel M, Stocker R, Stover JF: Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury Crit Care 2009, 13:R13 Page ... traumatic brain injury in rats J Neurotrauma 2001, 18:1011-1018 Zygun DA, Steiner LA, Johnston AJ, Hutchinson PJ, Al-Rawi PG, Chatfield D, Kirkpatrick PJ, Menon DK, Gupta AK: Hyperglycemia and brain...

2
211
0

Báo cáo y học: "Standardisation of data collection in traumatic brain injury: key to the future" pot

Ngày tải lên : 13/08/2014, 19:20

... the US towards ‘an integrated approach to research in Psychological Health and Traumatic Brain Injury References Maas AIR, Stocchetti N, Bullock R: Moderate and severe traumatic brain injury ... in the US into a much larger interagency initiative towards ‘an integrated approach to research in psychological health and traumatic brain injury This initiative included working groups on demographics ... funded as part of the interagency initiative in the US towards ‘an integrated approach to research in Psychological Health and Traumatic Brain Injury Page of (page number not for citation purposes)...

2
291
0

Báo cáo y học: "Effects of unilateral decompressive craniectomy on patients with unilateral acute post-traumatic brain swelling after severe traumatic brain injury" pps

Ngày tải lên : 13/08/2014, 20:21

... after three months In the routine craniotomy group, postoperative treatment was similar to those in the unilateral DC group Postoperative therapy was similar to that previously described, which included ... relevant to this topic, and this study aims to conduct the prospective trials on acute posttraumatic BS To our knowledge, the following factors are critical in surgical management of posttraumatic ... autoregulation assessment in traumatic brain injury: validation and utility J Neurotrauma 2003, 20:69-75 26 Salvatore C, Marco M, Antonio R, Salvatore I, Eugenio B: Combined internal uncusectomy...

7
503
0

Báo cáo y học: "Bench-to-bedside review: Hypothermia in traumatic brain injury" pot

Ngày tải lên : 13/08/2014, 20:21

... shown to be sensitive to post -injury temperature manipulations in models of ischaemia and trauma [42] The ability of post -injury temperature to aﬀect the acute and more delayed genetic response to ... evidence for apoptotic cell death has also been documented using various histochemical and molecular techniques As with necrosis, apoptotic cell death appears to be sensitive to post -injury hypothermic ... after traumatic brain injury Published: 15 February 2010 References European Brain Injury Society homepage [http://www.ebissociety.org/ head -injury. html] Ghajar J: Traumatic brain injury Lancet...

10
238
0

Báo cáo y học: " Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?" doc

Ngày tải lên : 13/08/2014, 23:20

... anti-inflammatory extra-pulmonary delivery deserves further exploration Figure Computed tomography scan at the level of the midbrain Computed tomography scan at the level of the midbrain Multiple ... = posterior; L = left; R = right sity of the left temporal lobe He was discharged to a rehabilitative traumatic brain injury unit on hospital day 34 Although he could follow commands, he had posttraumatic ... blocking agent, RU486 (mefepristone), though, was shown to be useful in this type of injury [34] Therefore, there may be neuroprotection afforded to those with TBI due to down-regualtion by GR causing...

6
286
0

Báo cáo y học: "Acute and delayed mild coagulopathy are related to outcome in patients with isolated traumatic brain injury" docx

Ngày tải lên : 14/08/2014, 07:21

... factor to progressive hemorrhage after traumatic brain injury J Neurosurg Anesthesiol 2006, 18:200-204 22 Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M: Towards definition, clinical and laboratory ... (41%) 11 (16%) 3.75 (1.07 to 13.51) 0.04* 59 ± 17 42 ± 19 1.07 (1.03 to 1.11) 0.001* 31 (91%) 35 (51%) 7.11 (0.60 to 84.53) 0.12 2.28 (0.14 to 37.72) 0.56 4.78 (1.35 to 17.00) 0.02* Age (years) ... in isolated head injury [1] Others reported aPTT and PT values ranging from 34 to 60 and 13 to 18 seconds, respectively, and an INR of >1.1 to 1.5 and platelet counts of 100 to 150*109/μl as...

7
314
0