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Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx

Báo cáo y học:

Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx

... further hydroxylated at position 1a by the mitochondrial cytochrome P450 enzyme 25-hydro-xyvitamin -D- 1a-hydroxylase (gene name: CYP27B1) and converted to the bioactive 1a,25- dihydroxyvitamin D (1,25-(OH)2 D 3). ... enzymes CYP27A1 and/ or CYP2R1 and subsequently by the cytochrome P450 enzyme 25-hydroxyvitamin D- 1a-hydroxylase (CYP27B1) and converted to the bioactive 1,25-(OH)2 D 3, which has role in Ca and ... functions of VitDhave been discovered, indicating that VitD regulatesmany cellular processes and is potentially involved in the development of many diseases. Since the discovery of VDRs in a variety...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... proposed roles for these residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) and the carboxylate of the a-amino-adipoyl side-chain (Arg266). The results ... group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this and previous ... oxidation.Penicillin substrate binding to DAOCS The results in this paper give support to the proposedmode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the...
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... wouldadvise that if these drugs are used as analgesics in thesesettings, their administration be for fairly short periods of time, probably not to exceed 10–14 days. I would be lessinclined ... and the two most widely prescribedcoxibs, celecoxib and rofecoxib. They showed that allthree drugs inhibited fracture healing, but the effects weremore profound when coxibs were used. They ... role of COX-2 in mesenchymal cell differentiation during skeletal repair.Using COX-1-null and COX-2-null mice, they demon-strated the essential role of COX-2 in both endochondral and intramembranous...
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Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx

... theseforms of OA. They include the type II and type XI col-lagenopathies, the multiple epiphyseal dysplasias (MEDs), and the metaphyseal chondrodysplasias. They are usuallyinherited as fully penetrant ... chondrodysplasias and associated hereditary OA have provided a betterunderstanding of the role of structural genes in the maintenance and repair of articular cartilage, in the regulation of chondrocyte ... deafnessHypochondrogenesisKniest dysplasiaOsteoarthritis with mild dysplasiaSpondyloepiphyseal dysplasia, congenital typeSpondyloepiphyseal dysplasia, Namaqualand typeSpondyloepiphyseal dysplasia, Strudwick...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf

... contributionsCLM participated in the design of the study, performed all lab-oratory work and analysis, and drafted the manuscript. AJFconceived the study and participated in its design and coordi-nation. ... conceived the study, participated in its design and coordination, and assisted in its analysis. All authors read and approved the final manuscript.Acknowledgements The authors wish to acknowledge the ... article The role of interleukin-1 in the pathogenesis of human Intervertebral disc degenerationChristine Lyn Le Maitre, Anthony J Freemont and Judith Alison HoylandDivision of Laboratory and Regenerative...
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Báo cáo y học:The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot

... microenvironmental conditions.Using RNA-interference, Yudoh and colleagues [1] furtheranalyzed the role of HIF-1 in chondrocytic energy generation,matrix synthesis and cell survival. During hypoxic and normoxic ... experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from celldeath induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary foranaerobic ... results provided in the study by Yudoh and colleagues and previous reports by us and other groups strongly support the notion that HIF-1 is of pivotal importance in cartilagedevelopment and homeostasis....
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Báo cáo y học: "The role of aldosterone blockade in murine lupus nephritis" pdf

... formalin for future paraffinembedding and sectioning.Histopathology studiesKidneys fixed in formalin were processed, paraffin embedded, and sectioned at 2 to 3 μm thickness. Hematoxylin and eosinor ... PCR and analyzed the data.AB assisted with mouse studies and performed the majority of the immunohistochemistry and immunofluorescence work.MJK conceived of the study, participated in its design, ... Levels of auto-Abs against single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) were determined by enzyme-linkedimmunosorbent assay (Alpha Diagnostic, San Antonio, TX,USA), as per the...
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Báo cáo y học: "The role of patient expectations in predicting outcome after total knee arthroplasty" ppsx

... for the conception and design of the main study, of which this substudy is part, and acquired funding for the project; they also coordinated all of the practical work and acquisition of data. ... performed the statistical analysis, interpreted the data and drafted the manu-script. SK organised and prepared the data for analysis, and assisted with some of the statistical analyses and with the ... analyses - and to state whether they would choose to undergo the procedureagain if they found themselves in the same situation, knowingwhat they now know about the outcome (yes, definitely; yes,probably;...
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Báo cáo y học: "The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates" doc

... the inserted TEs (LINEs) was found to be divisible by three and the sequences did not contain stop codons. Thus, the insertion of these TEs into the coding exons did not alter the reading frame of the downstream ... according to [43]. The letters y and r denote pyrimidine and purine, respectively. (b) Non-redundant distri-bution and orientation of exonized HE1 SINE sequences in which both the 5' and 3' ... show insertion of TEs into exons. The TE family is indicated beneath the gray box, along with the length of each inserted TE. Lengths of the introns and exons flanking the inserted exon are indicated....
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Báo cáo y học: "The role of codon selection in regulation of translation efficiency deduced from synthetic libraries" potx

... lgis the length of the gene in codons and wikis the relative adaptiveness value of the codon defined by the kth triplet in the gene.Here we refer to the wivalue of a single codon as the codon’ ... Partialcorrelation (codon i,OD|codonj). Third, find the minimum absolute value of the partial correlation foreach codon and rank the codons in a descending orderaccordingly. This gives us the codons with ... examined the effect of individual codons on cell fitness. We analyzed the correlation between the usage frequency of eachspecific codon in the GFP sequence (number of copies of the codon in the...
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