... toprotonation of the aspartate in the sugar-binding site,which can be a hydrogen-bond acceptor, or conformationalchange. As there is little conformational change among the crystal structures of MLI ... Tyr68, the main-chain atoms of Ala72 and Gly73, and Val74) makehydrophobic contact with the equivalent region in the othermolecule. In addition, Og of Tyr68 makes a hydrogen bondwith the side ... hydrogen bonds with the O of Gly32, are not conserved in RTB and ABB.However, Oc of Ser111 is located in a similar position toOc1 of Thr110 of RTB. Among the hydrophobic contacts,Ilel14 of MLB...