... LB: Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity bycytokines and inflammatory synovial fluids. ... notably the IL-6 family of cytokines (e.g. IL-6, IL-11, leukemia inhibitory factor, and oncostatin M) and growth factors, in addition to IL-10 [4]. Of these cytokines,IL-6 plays a predominant role ... CD28-costimulatedproduction of both IFN-γ and IL-2.Numerous cytokines, both proinflammatory and anti-inflam-matory, have been detected in the ST of RA, and the bal-ance between these opposing cytokine activities...