... pooledhuman IgG to a pH 4 buffer resulted in an increase in its pre-existing binding to antigens present in an Escherichia coli lysate, and in the appearance of somenew bands showing the acquisition of ... compilation ê 2010 FEBS Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis Iglika K. Djoumerska-Alexieva1,*, Jordan D. Dimitrov1,2,3,4,*, ... IVIg to recombinant human IFN-c. (D) Increased binding of low-pH buffer-exposed IVIg to human factor H. In both panels, binding of the native IVIg is indicated by a solid line, and that of the...