... Sp1 and Sp3 are able to bind to the GCboxes and that binding of Sp1 forms complex C1 and binding of Sp3 forms complexes C2 and C3.PMA treatment increases Sp1 and Sp3 proteinexpression in HL-60 ... upstream of the DNase II promoter, are essentialfor both basal and PMA-mediated induction of DNase IItranscription. These sites bind Sp1 and Sp3, and proteinlevels and binding of Sp1 and Sp3 are increased ... factors, may also be involved in increasing the DNA binding and transcriptional activities of Sp1. As shown in Fig. 4A, two DNA–protein complexesother than C1, C2, and C3 were detected in PMA-treatedcells,...