... maternal and child health inChina has been continuously improving, it is lagging behind the economic development of the country. The decline of infant and child mortality is slowing down, and great ... Regulations on Nurses Management inChinaand the Law on Practitioners inChina have played a positive role in strengthening and standardizing the management of health teams. However people ... between urban and rural areas and across regions and population groups and these are becoming more prominent. In 2004, MMR in rural areas was 3. 2 times that in urban areas; MMR in inland and remote...
... ApoE3knock -in and ApoE4knock -in mice todevelop obesityanditsrelated metabolic dysfunctions.Thus, in future studies, it would be interesting to inves-tigate whether the more obesity- prone ... School of Medicine, UCLA, Los Angeles, CA, USAIntroductionApolipoprotein E (ApoE) is a major protein of thelipid and lipoprotein transport system mainlyinvolved in the metabolism of dietary ... brain apoE expressionreduces food intake in rats. Specifically, the intrecere-broventricular injection of ApoE in rats decreasedtheir food intake, whereas intrecerebroventricular infu-sion of...
... line), in the presence of 100 lM neurotoxin (•, dotted line), in thepresence of 200 lM neurotoxin ( , dottedline) andin the presence of neurotoxin and 50 lM dopamine (h, dashed line).Modulation ... occur in the brain includeselective loss of dopaminergic neurons in substantianigra pars compacta and appearance of Lewy bodiesconsisting of aggregated protein, mainly a-synuclein, in Keywordsamyloid; ... pooled and the amount of protein was determined by the bicinchoninicacid assay [38] using bovine serum albumin as a standardprotein. The pooled eluate fractions were dialysed againstwater and...
... in ammation induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia. Similarly, hyperleptinemia is aconsequence of the development of insulin resistance in ... adenoviral overexpression of ANG-PTL6 ⁄ AGF in the liver of diet-induced obese miceresults in elevated ANGPTL6 ⁄ AGF serum levels and amelioration of diet-induced obesityand insulin resis-tance [14]. ... N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain,both characteristic of angiopoietins. ANGPTLs do not bind to either theangiopoietin receptor Tie2 or the related protein Tie1,...
... hormone-binding-globulin, leptin,insulin and insulin resistance in obese men. ArchAndrol 52, 355–361.19 Wannamethee SG, Shaper AG, Morris RW &Whincup PH (2005) Measures of adiposity in the ... pathophysiologicallinks including obesity- related androgen deficiency and obesity- induced endothelial dysfunction. Obesity promotes in ammatoryresponses and contributes toendothelial dysfunctionThe role of ... androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation.Several hypotheses have discussed the relationship of androgen deficiency and obesity. That obesity iscommonly...
... FEBSLevels of mTOR andits downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’sdisease brainXu Li1, Irina Alafuzoff2, Hilkka Soininen3, Bengt Winblad1 and ... proteins witheither polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinsondisease and synucleinopathies ... staining in the granulelayers of the dentate gyrus (not shown). In contrast, in control brain slices there was weak stainings in thepyramidal neurons of the CA1, CA2, CA3 and theentorhinal...
... galectin 3,an S-type lectin containing a carbohydrate-bindingdomain, as a physiological ligand of CD98 in vivo [18].Figure 5A shows the primary intracellular distribu-tion of galectin 3 in the ... antiapoptoticgalectin family member). Galectin 3 is composed of one carbohydrate recognition domain (CRD), consist-ing of 130 amino acids, andof an additional non-CRD domain, which is involved in the ... and in intestine [26]). Finally, there is evidence for galec-tin 3 as a factor in RNA splicing, based on the local-ization of the protein in the nucleus [27]. In this article, we further examine...
... simultaneousanalysis of all six binding curves, as in some casesparameters are shared between individual bindingcurves in order to reduce the number of free parametersas well as the uncertainty in the remaining ... relypredominantly on simple diffusion. Several lines of evidence [25–27], including the reduction in oxygenuptake when Hb–oxygen binding is blocked by carbonmonoxide [28] and the striking induction of ... (Fig. 7), which also visualizethe in uence of variations in the numbers of Mg2+-binding sites (m) and proton-binding sites (h) peroxygen-binding site.di-domain subunitdisulfide-bridged dimer...
... NM. Kamei, Shin-ichiro and Wakao, Takahiro. (1992). Metonymy: reassessment, sur- vey of acceptability, andits treatment in a machine translation system. Memoranda in Computer and Cogni- tive ... shown in Appendix A. The patterns are 1) Locating, 2) Emphasis of one aspect, 3) Abstract and collective entity for its con- sisting concrete items, and 4) Information conveyer for information ... (Lakoff and Johnson 1980) or Artist-for-Artform (Fass 1991), or both of them. A SURVEY OF METONYMY A comparative survey on acceptability of metonymic expressions in English, Chinese and...
... neuroendocrine and behavioralresponses. Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the induction of energy consumption.Energy homeostasis and ... The administra-tion of RFRP increases Fos expression in the hypotha-lamic paraventricular nucleus andin hypothalamicoxytocin neurons, and facilitates the release of ACTH and oxytocin into the ... effects of stress on foodintake and the effects of food intake on stressresponses have not yet been examined in PrRP-defi-cient mice. PrRP might be involved in the integration in the control of...
... 2009)doi:10.1111/j.1742-4658.2009.07302.x Obesity andits associated disorders, including diabetes and cardiovasculardisease, have now reached epidemic proportions in the Western world,resulting in dramatic increases in healthcare ... understand these processes will undoubt-edly contribute to strategies aiming to combat obesity andrelated dislipidemias.Much of our understanding of the involvement of adipose tissue in the ... of BMP7 in mice results in a specific increase in brown but not white fat, leading to weight loss and anincrease in energy expenditure [45].Adipose tissue remodeling and theredistribution of...
... effects unrelated to metabolism. These include theadipocyte-specific proteins adiponectin and leptin, the in ammatory chemokines tumor necrosis factor-a(TNFa) and an array of interleukins, and angiogenic and ... of WAT results in hypoxia and increased levels of HIF-1a that, in turn,lead to an up-regulation of the in ammatory adipokin-es interleukin-6, TNFa and monocyte chemotacticprotein-1, amongst ... network of blood capillaries, ensuring adequate exposure to nutri-ents and oxygen. WAT varies inits vascularity bothbetween depots and within the tissue itself. For exam-ple, the expanding tip of...
... (recurrent) myocar-dial infarction, and increased risk of mortality [4-7].Given the clinical relevance of findings on Type Dresearch in the context of cardiovascular disorders, itis also important ... selection criteria and removal of duplicate articles* Computerised search of databases and reference checking. 567 hits Figure 1 Flow diagram of papers accepted and rejected during selection procedure. ... health status and is associated with disease-promoting mechanisms and work -related problems in apparently healthy individuals.Introduction In the past decade, studies on the effects of Type D per-sonality...
... help in defining the standards of care at the local level. Theimplementation of standards of care and evaluationactivities should be tailored to the characteristicsof theservices that are being ... 1004. Information on risks and benefits of oral HT Number of women who were prescribed oral HT and who received informationabout its purpose, benefits and risks/Total number of women in the ... 80% of the questionnaire).Study description In each FMC, the nurse identified candidates in thewaiting room, explained the purpose of the study and of the interview, and asked for her signed informed...