... The association of heavy and light chain variable domains in antibodies: implications for antigen specificityAnna Chailyan1,*, Paolo Marcatili1,* and Anna Tramontano1,21 Department of Physics, ... contains four (heavychains) or two (light chains) intrachain disulfide bonds and is composed of multiple variants of a basicdomain (two for the light and usually four for theheavy chain) assuming ... Delagrave S, Catalan J, Sweet C, Drabik G, Henry A, Rees A, Monath TP & Guirakhoo F (1999) Effects of humanization by variable domain resurfacing on theantiviral activity of a single-chain...