Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
... to the regions of the protein involved in interaction with Cdk2 andcyclin A: 1, domain 1 interacting withcyclin A; 2, a linker helix involved in bindingboth cyclin A and Cdk2; 3, domain 2 inter-acting ... determine what fraction of protein protein interaction in regulatory networks relies on intrinsic disorder. AbbreviationsCaM, calmodulin; Cdk, cyclin-dependent protein kinase; CKI, Cdk inhibitor ... important roles in the binding interactions of these hub proteins. The xeroderma pigmentosumgroup A protein (XPA) represents an interesting exam-ple of a partially disordered hub protein. Xeroderma...
- 20
- 401
- 0
Báo cáo khoa học: "Re-evaluating the Role of B LEU in Machine Translation Research" ppt
... Bleu3(top)and of the entry that was ranked 6th in Bleu but1st in the human evaluation (bottom). The exam-ple is interesting because the number of match-ing n-grams for the two hypothesis translationsis ... only the hypothesis translation. Theyare then shown a reference translation and areasked to judge the adequacy of the hypothesis sen-tences.Table 4 gives a comparison between the output of the ... fairly serious problem of not being able to calculate recall.Each of these failures contributes to an increasedamount of inappropriately indistinguishable trans-lations in the analysis presented...
- 8
- 455
- 0
Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... clathrin light chain B; ENTH, Epsin N-terminal homology; HD, Huntington’s disease; HIP-1, huntingtin-interacting protein 1; HIPPI,huntingtin-interacting protein 1 interactor; Htt, huntingtin protein; ... decrease of the amount of HIP-1–HIPPI heterodimer and apoptosisinduction. The effect of HIP-1 may depend not onlyon the amount of the interacting proteins but also on the affinities of interacting proteins. ... Some of the Htt-interacting proteins also alter the pathogenicity in the Drosophila model of HD [13].Among 300 Htt-interacting proteins described sofar, HIP-1 is one of the most studied. The...
- 9
- 492
- 0
Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... repre-sent the last subunits incorporated into the bc1com-plex. On the other hand, the absence of Qcr9p in the DQCR9 ⁄ DQCR10 strain prevented the binding of ISP(Fig. 4B). Interestingly, in the ... comparable amounts in both yeast strains. Therefore, the reason for the disap-pearance of the bc1dimer in the yeast strain in whichQcr10p is missing remains unknown.On the basis of all the above ... complexes of the mitochon-drial respiratory chain, the assistance of specificchaperone proteins is also required. The available dataindicate that the accessory factor Bcs1p is involved in the binding...
- 15
- 639
- 0
Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
... 4F2hcproteins might have evolved. The GH13-like protein from the cnidarianNematostella vectensis might nowadays represent a protein close to the eventual ancestor of the hcHAT proteins within the ... domain,including domain B and the C-terminal domain C forrBAT proteins (669 residues on average); (b) the cata-lytic TIM barrel domain, including domain B and the C-terminal domain C for GH13 ... is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs andGH13 enzymes, and especially the...
- 14
- 564
- 0
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... belongsto the C2 domain (141 amino acids) with its extendedloops, whereas the lid-like region at the top representsanother flexible part of the structure. Assuming that the core protein containing the ... biospecific interactions. We assumethat calcium ions are involved in enzyme activation byguiding the protein to the membrane, mediating sub-strate binding, or adjusting the charge distribution at the ... estimated from isothermal titration calorimetry[36]. The C2 domains of other proteins showed cal-cium-binding affinities in the range of 1–50 lm [37,38].As the C2 domain of PLD a2 from cabbage...
- 11
- 750
- 0
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... the intensity for the a-tubulin signal. Shown are the relativeexpression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity representing ... reduces the expression levels of HO-2 mRNA and protein in five out of six cell lines, with the exception of KG1myeloid cells.Hypoxia decreases the expression levels of HO-2 protein in YN-1 and ... expressionlevels of HO-1 protein in these cell lines under hypo-xia. In contrast, the expression levels of HO-1 mRNAand protein were consistently decreased in HeLa andHepG2 cells. Interestingly, hypoxia...
- 12
- 621
- 0
Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... thatcytoskeletal protein 4.1 N, a member of the 4.1 family,facilitates the transport of D2R to the cell surface byinteracting with the N-terminal portion of the ic3 loop of D2R via its C-terminal domain ... localization of these proteins in the cell rather thanfrom the possible role of the D2R basic domain in the mechanism of D1–D2receptor heterodimerization. However, we find that the acidicepitope ... Measuring receptor dimer-ization by monitoring changes in the fluorescence life-time of probes linked to the receptors of interest seems the best approach in this kind of the study. Althoughthe...
- 16
- 567
- 0
Báo cáo khoa học: Investigations into the ability of an oblique a-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide pot
... methodology of Simpson [58]. The interaction parameter (a) relates the interaction of each molar fraction of components within a monolayerwith the free energy of mixing. Values of a were computed(Table ... monitored changes in the b fi a acylchain melting behaviour of phospholipids, with these changesdetermined as shifts in the peak position of the symmetricstretching vibration of the methylene groups, ... stable in the presence of AP1, further supporting the sugges-tion that this instability may contribute to the susceptibility of E. coli to the antimicrobial action of the peptide.DiscussionThe...
- 12
- 688
- 0
Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
... Irreg-ularities in multiple pathways involved in tissue repairand in ammation can lead to the development of fibrosis. Collagens are the predominant ECM proteins,while other ECM proteins such as fibronectins, ... that involved the binding of miRNA-369-3 to the AU-rich elementswithin the 3¢-UTR of TNF-a and the interaction between two miRNA-induced silencing complex-associ-ated proteins, Ago 2 and fragile-X-mental-retardation-related ... showing thatmiR-133 and miR-590 are down-regulated in a caninemodel of nicotine-induced atrial interstitial fibrosis[28,29]. Interestingly, mechanistic studies in the caninemodels and in cultured...
- 7
- 436
- 0
Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ