Nghiên cứu squalene từ vi tảo biển dị dưỡng schizochytrium mangrovei PQ6 định hướng làm nguyên liệu cho thực phẩm bảo vệ sức khỏe, mỹ phẩm và dược phẩm tt tiếng anh

MINISTRY OF EDUCATION AND VIETNAM ACADEMY TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY NGUYEN CAM HA RESEARCH ON SQUALENE FROM HETEROTROPHIC MARINE MICROALGA SCHIZOCHYTRIUM MANGROVEI PQ6 ORIENTED AS FEEDSTOCK FOR HEALTH FOOD, COSMETIC AND PHARMACEUTICAL Major: Biochemistry Code: 42 01 16 SUMMARY OF BIOLOGY DOCTORAL THESIS Ha Noi - 2020 The doctoral thesis was completed at: Institute of Biotechnology, Graduate University of Science and Technology, Vietnam Academy of Science and Technology Scientific supervisor: Prof Dr Dang Diem Hong Institute of Biotechnology Reviewer 1: … Reviewer 2: … Reviewer 3: … The doctoral thesis will be defended at the graduate university committee of doctoral thesis evaluation at Graduate University of Science and Technology, Vietnam Academy of Science and Technology on…………, date…… month…….year 2020 See the detailed thesis at: - Library of Graduate University of Science and Technology - Vietnam National Library LIST OF PUBLISHED WORKS (09) Nguyen Cam Ha, Hoang Thi Minh Hien, Nguyen Hoang Ngan, Dang Diem Hong, Safety assessment and the effect of squalene isolated from Schizochytrium mangrovei PQ6 on serum HDL - Cholesterol levels in animal models Academia Journal of Biology, 2019, 41(2), 39-48 (in Vietnamese) Hoang Thi Lan Anh, Nguyen Cam Ha, Le Thi Thom, Hoang Thi Huong Quynh Pham Van Nhat, Hoang Thi Minh Hien, Ngo Thi Hoai Thu, Dang Diem Hong, Different fermentation strategies by Schizochytrium mangrovei strain PQ6 to produce feedstock for exploitation of squalene and omega-3 fatty acids Journal of Phycology, 2018, 54 (4), 550556 (SCI, Q1; IF-3.0) Nguyen Cam Ha, Hoang Thi Minh Hien, Dang Diem Hong, Hypocholesterolemic mechanisms of squalene extracted from Schizochytrium mangrovei PQ6 in hepatocytes Proceeding of national Biotechnology conference 2018, Publishing house of natural sciences and technology; 2018, 589-594 (in Vietnammese) Nguyen Cam Ha, Hoang Thi Minh Hien, Le Thi Thom, Hoang Thi Huong Quynh, Dang Diem Hong, Optimization of fermentation conditions for squalene production by heterotrophic marine microalgae Schizochytrium mangrovei Academia Journal of Biology, 2017, 39(3), 449-458 Hoang Thi Minh Hien, Nguyen Cam Ha, Le Thi Thom, Dang Diem Hong, Squalene promotes cholesterol homeostasis in macrophage and hepatocyte cells via activation of liver X receptor (LXR) α and β Biotechnology Letters, 2017, 39 (8), 1101-1107 (SCI, Q2; IF-1.7) Dang Diem Hong, Nguyen Cam Ha, Le Thi Thom, Luu Thi Tam, Hoang Thi Lan Anh, Ngo Thi Hoai Thu, Biofuel from Vietnam heterotrophic marine microalgae: Biodiesel and salvaging co-products ((polyunsaturated fatty acids, glycerol and squalene) during biodiesel producing process Journal of Biology, 2017, 39 (1): 51-60 (in Vietnamese) Nguyen Cam Ha, Le Thi Thom, Hoang Thi Huong Quynh, Pham Van Nhat, Hoang Thi Lan Anh and Dang Diem Hong, Extraction of squalene from Vietnam heterotrophic marine microalga Proceeding of The the Academic conference on natural Science for Yong Scientists, Master & PhD Student from Asian Countries 15-18 December, 2015 Bangkok, Thailand, 2016, 46-56 Hoang Thi Lan Anh, Nguyen Cam Ha, Le Thi Thom, Dang Diem Hong, Optimization of culture conditions and squalene enrichment from heterotrophic marine microalga Schizochytrium mangrovei PQ6 for squalene production Research Journal of Biotechnology, 2016, 14 (2), 337-346 (SCI-E) Nguyen Cam Ha, Le Thi Thom, Đang Diem Hong, Hoang Minh Hien, Study on Hypolipidic effect of squalene extracted from heterotrophic marine microalgal Schizochytrium sp on HepG2 cells Journal of Pharmacutical, 2016, 21 (4), 270 -274 INTRODUCTION The urgency of the thesis Viet Nam has over 3200 km of coastline with a diversity of tropical marine organisms, rich in species composition and natural compounds that can be used in the food industry, agriculture, medicine… Microalgae with the main advantages of being rich in nutrients, small cells (