... suggested that the N-terminal a-helix of CB1 is located on the surface of the lipid bilayers, whereas the C-terminal a-helix of CB1 is embedded below the surface of the lipid bilayers These conclusions ... surface and tested liposome-free chips for Ó FEBS 2003 Identifying the disruptive mechanisms of cecropins B, B1 and B3 (Eur J Biochem 270) 917 Fig Microscopic observations of the effect of CB, CB1 and ... antimicrobial defence peptides such as cecropins [1] disrupt cell membranes, and thereby kill their targets, by associating with the membrane lipids [21] The mechanism of bilayer disruption by cecropin A...