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Báo cáo y học: "High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy" doc

Báo cáo y học:

Báo cáo y học: "High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy" doc

... 1Use of corticosteroids in systemic sclerosis subtypesUse of corticosteroids in systemic sclerosis subtypes. dcSSc, diffuse cutaneous systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis. Arthritis ... not for citation purposes)Vol 11 No 2Research articleHigh frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacyNicolas ... immunosuppressive therapy in a large, well-defined cohort of SSc patients. The study reveals a wide-spread use of anti-inflammatory and immunosuppressive ther-apy of SSc patients in clinical practice and...
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Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx

... cytolytic proteins perforin and granzyme B and are functionally specialized for cytotoxic activity [17].Perforin was found in CD4+CD28–peripheral blood lym-phocytes, and CD4+perforin-positive ... duration12.7 years), included 8 patients with nodulosis, 4 with anemia and nodules, 1 with vasculitis and nodules, 4 with vasculitis only, 1 with vasculitis and amyloidosis, and 2 with sicca syndrome and ... populations.ResultsAbsolute lymphocyte numbers in patients with RA and controls were not different. The median frequency of CD4+CD28–T cells was 1.40% in the healthy controlpopulation and 7.86% in patients with...
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Báo cáo y học: "Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis" docx

... (4 patients) ,cyclosporine A (5 patients: 2 in combination with MTX, 1 in combination with leflunomide, 1 in combination with azathio-prine, and 1 with sulfasalazine), and azathioprine (2 patients) .Nine ... Vitamin D binding protein (Gc-globulin).Endocr Rev 1989, 10:294-307.18. Lind SE, Smith DB, Janmey PA, Stossel TP: Role of plasma gel-solin and the vitamin D-binding protein in clearing actin ... present in synovial fluids of rheumatoid arthritis patients Various amounts of actin were detected in SFs of 77 of the 81RA patients and in plasmas of 19 of the 78 patients by immu-noblotting...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"

... stems from a cohort study of eastern Finnish men, in which high levels of serum ferritin and dietary Fe intake were positively associated with the incidence of myocardial infarction. Ascherio ... signficant increase in urine Cu levels in patients suffering from myocar-dial infarction (MI) (15). Reunanen et al. (1996) found increased levels of serum Cu in patients with CAD (14). In contrast, ... significantly different in patients with and without CAD (Table 1). Comparisons of the levels of the vitamins (retinol, tocopherol and cholecalcifer-ol), and trace elements and heavy metals (Zn,...
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Báo cáo y học: "Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus" pot

... 6months of immunosuppressive therapy (five out of eight (62%)nephritis patients in our series, 30% in the study by Moroni and colleagues [32], and 47% in the study by Fang and col-leagues [29]). In ... months in 5 patients and ≥ 12 months in 10 patients (1 to 2 years in four patients, 2 to 5 years in five patients, and 16 years in one patient). Lupus treatment at the time of serumsampling in the ... for identifying patients at low risk. All 14 patients with Figure 2Follow-up of anti-C1q and anti-dsDNA titers in systemic lupus ery-thematosus patients with nephritisFollow-up of anti-C1q and...
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Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis" ppsx

... three minutes and thensubjected to 40 amplification cycles of 94°C for 30 seconds,62°C for one minute and 72°C for one minute, followed by afinal elongation cycle of 72°C for five minutes. ... titer of 1:320 was used as a stringentcriterion for ANA positivity.Statistical analysisAllele and genotype frequencies of CCR5 d32 were obtainedby direct counting. For allele and genotyping ... the comparatively high frequency of theallele in our Saxonian, German population. In the initial studycohort, heterozygotes and homozygotes combined account for 25% of healthy controls, which...
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Báo cáo y học: "Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series" doc

... rhythm (patients 1 and 4) ) wasassociated to refractoriness to agomelatine within3 months of 50 mg/day therapy. This appears to be con-sistent with evidence in the current literature pointingout ... for agomelatine, as potentially occurred in patient 3. Simi-larly, life stress may lead to mood and/ or anxiety disor-ders (including OCD) by causing disruptions in individuals’ social routines and, in ... transient, self-remitting dizzinessdid not preclude continuation of agomelatine.Finally, despite a number a methodological and clini-cal constraints and the very preliminary nature of theresults,...
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Báo cáo y học: "Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis" pptx

... early RA and matched controls, and of 31 patients with early RA at baseline and one yearBrachial dilatation of 20 patients with early RA and matched controls, and of 31 patients with early RA ... attack at 52 years of age, two males with a history of angina at the ages of 48 and 64 years, and one patient with myocardial infarction (MI) at age 48 years. Twenty of these RA patients could ... anti-inflammatory effects of treat-ment. In a study of patients with longstanding RA, where those with a history of CV disease or CV risk factors including smok-ing were excluded, GMD in the...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"

... Guernsey DL: Genetic poly-morphisms of microsomal epoxide hydroxylase and gluta-thione s-transferases m1, t1 and p1, interactions with smoking, and risk for esophageal (barrett) adenocarcinoma. ... ZW, Taylor PR, Dawsey SM, Qiao YL: Polymorphic variation of cyp1a1 is associated with the risk of gastric cardia cancer: A prospective case-cohort study of cytochrome p-450 1a1 and gst enzymes. ... interactive with some lifestyle and dietary habits, but is not a signifi-cant independent susceptibility factor. The p53 tumor suppressor pathway is well-known to be crucial in maintaining genomic in- tegrity...
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Báo cáo y học: "A review of anatomical and mechanical factors affecting vertebral body integrit

... vertebrae, particularly in vertebrae with altered extrinsic and intrinsic structural integrity. Peak loads in individuals will vary due to differences in activity levels and incidences of traumatic events ... for providing controlled movement and stability. Maintaining controlled movement and stability in the trunk may minimise the risk of sustaining a vertebral fracture. To ensure stability and optimal ... dominates in the elderly spine. Generally, women loose 20% of peak cortical bone mass and 40-50% of trabecular mass by 90 years of age [58]. This results in a decline in the load-bearing capacity of...
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