... gene in the Japanese population,namely NAT2*4, NAT2*5B, NAT2*5E, NAT2*6A, NAT2*7Band NAT2*13. Of these, NAT2*4 is the wild-type haplotype; the remaining haplotypes are mutant types. In the presentstudy, ... optimization of co-trimoxazole therapy in patients with systemic lupus erythematosus (SLE), weinvestigated genetic polymorphisms in the NAT2 gene (whichencodes the metabolizing enzyme of sulphamethoxazole). ... day 14Table 2 Association between diplotype configurations at the NAT2 gene and adverse events with co-trimoxazole, analyzed in the cohort study Diplotype configuration Acetylator phenotype With...