... the amino-terminal transactivation domain (NAD) and the carboxy-terminal transactivation domain (CAD) [74,75]. Functionalanalysis revealed that the activity of both the NAD and CAD were enhanced ... Molecular Genetics of Development,University of Adelaide, Australia;2CSIRO Health Sciences and Nutrition, Parkville, Victoria, AustraliaTo sustain life mammals have an absolute and continualrequirement ... forthe activation of hypoxia-inducible factor 1. J. Biol. Chem. 276,21166–21172.118. Aragones, J., Jones, D.R., Martin, S., San Juan, M .A. , Alfranca, A. ,Vidal,F.,Vara ,A. ,Merida,I.&Landazuri,M.O.(2001)Evidence...