... Abraham RT &Samelson LE (1999) Functional analysis of LATin TCR-mediated signaling pathways using aLAT-deficient Jurkat cell line. Int Immunol 11, 943–950.102 Sommers CL, Menon RK, Grinberg ... due to their small sizeand dynamic nature, difficult to observe directly, theycan be visualized using, for example, specific lipidprobes [29] or electron microscopy [30,31]. A specialtype of ... stress results in conformationalchanges (the formation of intramolecular dislufidicbridges) causing membrane displacement of LAT andconsequent hyporesponsiveness of T lymphocytes [61].LAT,...