Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx
Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx
... complex with cathepsin < /b> B after binding 2A2 mAb. The lack of < /b> dissociation of < /b> cathepsin< /b> A B Fig. 6. Dissociation of < /b> cystatin C from the cathepsin < /b> B ⁄ cystatin Ccomplex by 2A2 mAb as shown by size exclusion ... exopeptidase activity of< /b> cathepsin < /b> B in the presence of < /b> 2A2 mAb. Furthermore, 2A2 mAb also inhibited cathepsin < /b> B endopeptidase activity, as determined by the degradation of < /b> DQ-col-lagen IV and BODIPY ... thepresence of < /b> various concentrations of < /b> 2A2 mAb. Thebinding of < /b> 2A2 mAb was followed by native gel elec-trophoresis. Increasing the concentration of < /b> 2A2 mAbat a fixed molar ratio of < /b> cathepsin < /b> B and...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
... proteins(Bad, Bid, Bik, Blk, Hrk, BNIP3 and BimL). Bcl-2family proteins mostly mediate the activity of < /b> otherproteins in the same family [74]. Antiapoptotic Bcl-2family members bind to pro-apoptotic ... dissociation of < /b> Bax and Bad from 14-3-3 is pro-moted by JNK via phosphorylation of < /b> 14-3-3 atSer184; this reduces the affinity of < /b> 14-3-3 for Bax andBad and translocation of < /b> Bax and Bad to mitochon-dria ... Inactivated Bax isphosphorylated at Ser184 by the physiological Baxkinase Akt, and heterodimerizes with antiapoptoticBcl-2 family members such as Bcl-xL [83]. Activation of < /b> Bax by dephosphorylation...
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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
... DNA-binding activity isincreased, but the amount of < /b> HSF2 protein simultaneously decreases, at least in part, because of < /b> enhanced ubiquitination by the E3 ligaseAPC ⁄ C followed by degradation by ... capacity of < /b> HSF1 isrepressed through a negative-feedback loop via binding of < /b> HSPs.The DNA-binding activity of < /b> HSF1 is inhibited by acetylation of < /b> sev-eral lysines, including K80, within the DBD. ... activation cycle of < /b> HSF1, bothDNA-binding and transcriptional activities must beattenuated (Fig. 1B) . The attenuation mechanism can-not be explained solely by the negative-feedback loop,because an...
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Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt
... alsoinvestigated by equilibrium binding. This revealed ahyperbolic binding curve (Fig. 4D) with a stochiometry of < /b> 1 : 1 of < /b> dTTP bound per subunit of < /b> dCTPdeaminase.Mutational analysis of < /b> amino acid ... synthesis described above are very similar froma regulatory point of < /b> view. dCMP deaminase is activa-ted by dCTP and inhibited by dTTP and both nucleo-tides act on the enzyme by binding to an ... cooperativity of < /b> dCMP binding [5,29,30].The activity of < /b> dCTP deaminase depends on the con-centration of < /b> dCTP and is inhibited by dTTP. Ourresults suggest that regulation < /b> of < /b> dCTP deaminase isnot by a...
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
... mutant forms and incubated in the absence of< /b> inhibitors.Ó FEBS 2004 Regulatory mechanisms of < /b> the CTGF/CCN2 gene (Eur. J. Biochem. 271) 4445previously detected by western b lot analysis using ... mediated by stabilization of < /b> CTGF/CCN2 m RNA rather t han by t ranscription of < /b> theCTGF/CCN2 gene. This post-transcriptional control pro-vides a n additional means of < /b> i ncreasing the exp ression of < /b> ... 5,13–25.41.Leask,A.,Holmes,A.,Black,C.M.&Abraham,D.J.(2003)Connective tissue growth factor gene regulation < /b> . Requirements f orits induction by transforming growth factor-beta 2 in fibroblasts.J. Biol. Chem....
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Tài liệu Báo cáo khoa học: Regulation of the actin–myosin interaction by titin doc
... Mol. Biol. 481,387–348.Ó FEBS 2004 Effect of < /b> titin on actin–myosin activity (Eur. J. Biochem. 271) 4581 Regulation < /b> of < /b> the actin–myosin interaction by titinNicolas Niederla¨ nder1, Fabrice ... hand, the percent-age of < /b> T800 bound to actin was not affected by ATP and/or by CaCl2but it was decreased by elevating ionic strengthfrom 80 to 180 mMwith average values of < /b> 62.3 ± 2.2%and 45.1 ... skeletal myofibrils. Biochem. J. 290,731–734.43. Astier,C.,Raynaud,F.,Lebart,M.C.,Roustan,C.&Benyamin,Y. (1998) Binding of < /b> a native titin fragment to actin is regulated by PiP2. FEBS Lett....
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... most probable reason why direct role of< /b> MPTP in animal models has not been observed so farcould be because in living systems, MPTP is metabo-lized to MPP+ by MAO -B and aggregation of < /b> a-syn-uclein ... inhibition of < /b> fibrillation, probably by the accu-mulation of < /b> spherical oligomers which were nonamy-loidogenic but cytotoxic [14,18]. In the presence of< /b> MPTP, dopamine accelerated the rate of < /b> fibrillation,leading ... not exhibit any Parkinson’sdisease-like symptoms [13]. Because the basis of < /b> action of < /b> MPP+had been hypothesized to be inhibition of< /b> mitochondrial complex I [32], the mode of < /b> action of< /b> MPP+needs...
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Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt
... inhibition by bis-ANSTo evaluate whether bis-ANS had an effect on theenzymatic activity of < /b> HSL, lipase assays were per-formed with increasing amounts of < /b> bis-ANS using TOas substrate. Bis-ANS ... BSA in the assay bufferand the lipid substrate emulsion, but not in the prein-cubation buffer, in accordance with the observationthat LPL was not inhibited by bis-ANS when BSAwas present in ... by theobservation that even though the HSL–bis-ANS com-plex has a Kd of < /b> 1 lm (Fig. 3), much higher concentra-tions are needed to decrease HSL activity (Fig. 2).Scavenging of < /b> bis-ANS by BSA...
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Tài liệu Báo cáo khoa học: Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice ppt
... endotoxemia.Free Radic Biol Med 37, 1472–1478.19 Brown GC (2001) Regulation < /b> of < /b> mitochondrial respir-ation by nitric oxide inhibition of < /b> cytochrome c oxidase.Biochim Biophys Acta 1504, 46–57.20 ... added to the buffer beforethe reaction was started. Control incubations were per-formed in the absence of < /b> NADPH. The reaction wasstopped by adding 400 lL of < /b> cold 0.1 m Hepes buffer con-taining ... mtNOS activity (Fig. 1A). aMT also restoredmtNOS activity that had been depressed by sepsis inmutant mice (Fig. 1B) .Some considerations should be borne in mindregarding the purity of < /b> the...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... followed by westernblotting for Shc, phospho-Erk and total Erk levels. (C) Rescue by ectopic Shc isoform expression of < /b> Erk activation that was suppressed by down -regulation < /b> of < /b> endogenous Shc. Stable ... suppressed by the Src-specific inhibitorCGP77675 as well as by the MEK1 inhibitor UO126and partially attenuated by the PI3K inhibitor Wort-mannin. No effect was observed with inhibitors of < /b> p38MAPK, ... observedErk phosphorylation was due to the blocking activity of < /b> Decma, we depleted Decma antibody molecules withAC B a b cda b cdFig. 1. Effects of < /b> Decma treatment on E-cadherin distribution,...
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