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bone metastasis microenvironment participates in the development of androgen ablation refractoriness and chemotherapy resistance of prostate cancer cells residing in the skeleton clinical implications

báo cáo khoa học:

báo cáo khoa học: "Angiogenesis inhibitors in the treatment of prostate cancer" pdf

Báo cáo khoa học

... tyrosine kinases, primarily by binding the ATP binding domain, has led to investigation of tyrosine kinase inhibitors as angiogenesis inhibitors In general, because tyrosine kinases are involved in ... rising PSA levels Thus, the activity profile of sunitinib appears to be similar to that of sorafenib in this setting The findings of this study again highlight the need for better markers of clinical ... Latham L, Steinberg SM, Jones E, Chen C, Dahut W: Pre -clinical and clinical evaluation of estramustine, docetaxel and thalidomide combination in androgen- independent prostate cancer BJU Int 2007,...
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Tài liệu Constructing Civil Liberties Discontinuities in the Development of American Constitutional Law pdf

Tài liệu Constructing Civil Liberties Discontinuities in the Development of American Constitutional Law pdf

Cao đẳng - Đại học

... State.”18 And the second involved the ongoing ideological work of constructing that perpetually altering and expanding state – including, in its inception, the trimming and even jettisoning of commitments ... are slow in re-valuing the whole and reorganizing the broad outlines of the theme in light of these discoveries.” There remains a persistent “tendency to patch the new research into the old story ... by beginning with the end In so doing, it imagines the long stretch of constitutional development concerning the criminal process provisions of the Bill of Rights as the kernels of later developments,...
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Sources in the Development of Mathematics pot

Sources in the Development of Mathematics pot

Toán học

... subtracted from the next above, the remainder from the term then next above, and so on, to obtain the jya (sine) of the arc So if r is the radius and s the arc, then the successive terms of the repeated ... a degree in theology from the University of Basel, intending to go into the ministry He then traveled in Europe, coming into contact with the Dutch mathematician Hudde and members of the Royal ... This page intentionally left blank Sources in the Development of Mathematics The discovery of in nite products by Wallis and in nite series by Newton marked the beginning of the modern mathematical...
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Báo cáo khoa học:

Báo cáo khoa học: "The key role of semantics in the development of large-scale grammars of natural language" pdf

Báo cáo khoa học

... results in trimming something off something else; in the case of example (9) above trimming the bush results in trimming the dry branches off the bush And this is what the semantic type in (16) ... argument of the embedded stateof-affairs Finally, as far as direct arguments are concerned, in Koenig and Davis (2000) these are predicted to link off the value of the KEY attribute 3.1 The verbs ... Impingement Predicates In order to capture the semantic properties of the arguments of the most representative verb of the impingement predicates class in German, the verb schlagen (hit) in examples...
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recent progress in the development of nano - structured conducting

recent progress in the development of nano - structured conducting

Vật lý

... molecules in defined area on the electrodes Also the use of conducting polymers in the area of bioanalytical sciences is of great interest since their biocompatibility opens up the possibility of using ... [88] and polyaniline [89] tubes In template self-assembly, the individual components interact with each other and an external force or special constraint [90] The development of nano-structures in ... and their applications in biomedical research Increasing interest in and practical use of nanotechnology, especially, in conducting polymers and polymer composites have lead the researchers to the...
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Policy Issues in the Development of Personalized Medicine in Oncology doc

Policy Issues in the Development of Personalized Medicine in Oncology doc

Sức khỏe giới tính

... 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute ... become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, � and the scientific and ... the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the selection of its members, sharing with the...
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Policy Issues In The Development Of Personalized Medicine in Oncology docx

Policy Issues In The Development Of Personalized Medicine in Oncology docx

Cao đẳng - Đại học

... 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute ... become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, � and the scientific and ... the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the selection of its members, sharing with the...
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Báo cáo khoa học:

Báo cáo khoa học: "Current Research in the Development of a Spoken Language Understanding System using PARSEC*" ppt

Báo cáo khoa học

... for extracting the prosodic information from the speech signal and incorporation of this information into the PARSEC framework In addition, we will be working to interface PARSEC with the speech ... by this amount In contrast, Bear and Price, by doubling the size of the grammar are multiplying the processing time by a factor of when no prosodic information is available (assuming (2n) = 8n ... utilizing will [1] J Bear and P Price Prosody, syntax, and parsing In Proceedings of the ~8th annual A CL, 1990 [2] R Helzerman and M.P Harper Parsec: An architecture for parallel parsing of constraint...
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

Báo cáo khoa học

... lipolysis Development of : a) Diet-induced obesity b) Insulin resistance c) Glucose intolerance Fat cells Fig Model for the role of ApoE in the development of diet-induced obesity in mice Dietary ... Despite the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heart disease, the functional interactions between adipose tissue and the lipid and lipoprotein ... of these mice worsened the glucose tolerance and insulin sensitivity of the ApoE) ⁄ ) · Ay ⁄ + mice, and triggered obesity, indicating that circulating ApoE is involved in increased adiposity and...
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nanotalk. conversations with scientists and engineers about ethics, meaning, and belief in the development of nanotechnology, 2006, p.378

nanotalk. conversations with scientists and engineers about ethics, meaning, and belief in the development of nanotechnology, 2006, p.378

Vật lý

... an otherwise inaccessible world of other, and in so doing, to see that they are included in the reflection of the public mirror of the nanotechnology initiative One interesting aspect of the ... so in terms of the motivations and the aggression and the funding and the push—I read the testimonies from this summer to the Senate Subcommittee on Science and Technology and they were all the ... Values in Nanotechnology Research and Design: The Case of the Aerogel 140 Timothy 142 Meaning Making 160 The Making of Meaning 160 The Negotiation of Self in Technology 162 Intentionality and Responsibility...
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Báo cáo hóa học:

Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt

Hóa học - Dầu khí

... of Polo-Like Kinase Evaluation of the results obtained in the two systems showed deregulation of the same pathways in human SCLC and in that induced experimentally by the E6/E7 oncoproteins of ... release the E2F transcription factor, subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the ... colorectal cancer [30] Furthermore the association between the presence of HPV 16 and the development of head and neck cancer has been recently established [31] The possible involvement of HPV in bronchial...
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Báo cáo sinh học:

Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf

Hóa học - Dầu khí

... the cancer cells, the Page of 14 characteristics of the used MSC, on the integrity of the immune system and on the timing and site of injection Two possible mechanisms have been postulated for the ... Removal of the cells from the context of a developing embryo and enforcing in vitro culture has been proposed as the cause for the increased tumourigenic potential of ESC when compared to the originator ... therapies An example is the use of stem cell therapy in the treatment of myocardial infarction (MI) One of the main safety concerns is the occurrence of arrhythmias [98,104] These were seen in...
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báo cáo hóa học:

báo cáo hóa học: " Cognitive interviewing methodology in the development of a pediatric item bank: a patient reported outcomes measurement information system (PROMIS) study" docx

Hóa học - Dầu khí

... out of six of the children defined "go out" as going outside to something or to play outside This resulted in some of the children factoring the weather into the state of their asthma Another ... about the number of days and nights in the previous week the child had coughing, wheezing, or shortness of breath, the number of times in the previous week the child used rescue medication, and the ... elicit information regarding the clarity and rationale of the directions, the meaning of the items, the appropriateness of the response choices, and overall comments on the relevance and complexity...
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báo cáo hóa học:

báo cáo hóa học: " Participatory design in the development of the wheelchair convoy system" potx

Hóa học - Dầu khí

... factors in this prototype of the WCS were the limited field of view of the camera, lack of degrees of free- dom in the camera mounting, and the low quality of the image The field of view and lack of ... on the number of rotations of the spool holding the string, and determined the angle between the leading wheelchair and trailing wheelchair based on a second encoder connecting the top of the ... angle of the string connecting them The distance between the wheelchairs determined the trailing wheelchair's speed, and the angle of the string determined the magnitude of turn http://www.jneuroengrehab.com/content/5/1/1...
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báo cáo hóa học:

báo cáo hóa học: " Involvement of β-chemokines in the development of inflammatory demyelination" ppt

Hóa học - Dầu khí

... mononuclear cells in the perivascular space during the recovery phase of an acute event, and may therefore be involved in the regulation of recovery rather than in the initiation of the disease In addition, ... understanding concerning the role of these CC chemokines and their receptors in inflammatory demyelination was greatly advanced by studies in the EAE model In mice, the increased expression of MCP-1 ... strengthening of circulating T cells to VCAM-1 on endothelial cells Postulating the involvement of chemokines in the integrin-mediated arrest of autoreactive T cells at the BBB, the investigators [3] subsequently...
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Education and training in the development of high quality human resources in vietnam at present

Education and training in the development of high quality human resources in vietnam at present

Tiến sĩ

... resources and the role of education and training in the development of high-quality human resources in Vietnam at present - Clarifying the real situation of the role of education and training in the development ... the training of pupils and students and to the discovery of, fostering, training, using, and attracting the talented people Nguyen An Ninh (2009), Book Bringing into Full Play the Potential of ... Studying the realities of the role of education and training in the development of high-quality human resources in certain higher institutions in Vietnam at present - In term of time scope, the thesis...
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Báo cáo khoa học:

Báo cáo khoa học: "SemiPro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis" pptx

Báo cáo khoa học

... pro-inflammatory cytokines IL-1b, IL-6 and TNF in the jejunum and colon of the DA rat following radiotherapy, thus confirming the importance of these cytokines in the development of mucositis Pro-inflammatory ... in the intestinal epithelium of rats receiving radiotherapy Previous research into expression at the protein level has shown conflicting findings In one study, proinflammatory cytokine protein ... IL-1b In general, there was weak-moderate IL-1b staining in the jejunal crypts There was predominantly weak staining of the villi The intensity of IL-1b staining fluctuated throughout six weeks of...
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Báo cáo y học:

Báo cáo y học: "Roles of planar cell polarity pathways in the development of neutral tube defects" ppsx

Báo cáo khoa học

... mutated embryos, the polarity of the ommatidia of the compound eye and the hairs of the wing and thorax are disrupted, such that rather than pointing in the same direction, they point in multiple ... participated in data and information collection and part of the writing XH performed part of text writing and the editing of the whole manuscript YH wrote the part of the manuscript and information ... to the orientation of the cell’s sides with respect to the global axis of the epithelium, allows the polarity of the cell to be established within the plane of the epithelium and promotes the...
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Báo cáo y học:

Báo cáo y học: "Role of PPAR-δ in the development of zymosaninduced multiple organ failure: an experiment mice study" pot

Báo cáo khoa học

... expression of Pselectin in the endothelium of small vessels and upregulated the surface expression of ICAM-1 and P-Selectin on endothelial cells in the pancreas, lung and gut In contrast, there was ... http://www.journal-inflammation.com/content/7/1/12 anesthesia in order to evaluate the development of acute inflammation in the peritoneum Through an incision in the linea alba, ml of phosphate buffered saline ... reducing the pathophysiology of MOF A histological resolution of organ damage to administration of GW0742 was highlighted in pancreas, lung and gut by haematoxylin-eosin staining too Indeed, the...
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