risk factors that contribute to the development of prostate cancer

... Urology 2003, 62:11-20. 6. Bonkhoff H: Role of the basal cells in premalignant changes of the human prostate: a stem cell concept for the development of prostate cancer. Eur Urol 1996, 30:201-205. 7. ... cascade of intracellular signalling activations that lead to the binding of downstream transcription factors, e.g., Gli1, Gli2 and Gli3 to their target sequences and then expression of target ... (Figure 2F to 2J) and CaP (Figure 2K to 2O) of the pCX-shh-IG-injected prostates, in contrast to the almost absence of expression in the vehicle controls (Figure 2A to 2E), except that few basal...

Ngày tải lên: 10/08/2014, 05:21

... to tumor regression. Therefore, factors that contribute to telomere stability may influence the efficiency of the drugs that have potential in cancer therapy. These factors in rela- tion to telomere length ... are calculated as the ratio of the telomere fluorescence signal (TFS) of the sample to that of the internal control, normalized to the DNA values at the G 0 /G 1 phase. The use of an internal control ... useful indica- tor of telomerase activity in normal and malignant tissues. Telomere length stability is one of the important factors that contribute to the proliferative capacity of many cancer cell types;...

Ngày tải lên: 17/03/2014, 09:20

... Q content relates to the enzyme’s functional temperature range and that BLXI thermostability is also directly related to the binding of specific metals as cofactors. At the same time, the simple relationship ... temperatures. The lower stability and lower E a of inactivation of BLXI in the presence of Mg 2þ reflect the fact that the enzyme binds Mg 2þ with lower specificity (the K act of Mg 2þ is 10 times higher that ... unfolding to the extent that Co 2þ does [39,40]. The E a values of BLXI inactivation were calculated for the apoenzyme in the presence and absence of metals (Table 3). The nature of the metal...

Ngày tải lên: 22/02/2014, 07:20

... for the other side to be convinced they are losers. How long are you willing to give them to stampede out of their positions? 10. If they do not stampede out of their positions, what will that ... Financial Risk Taking The purpose of this book is to present a synthesis of contributions to the psychology of financial risk taking (I will use the term “trading” as synonymous with “financial risk ... disappoint the predominant force? 13. What is the likelihood of that happening? 14. What is the risk of finding out in a trade? 15. Is there enough potential for movement to make the trade worth the risk? These...

Ngày tải lên: 03/05/2014, 13:15

... cells to be one of the important sources of IL-32 in the pathogenesis of inflammatory arthritis. To exam- ine the proinflammatory effects of IL-32 produced by CD4 + T cells, we transduced the ... inflammatory arthritis and is thought to be an autoimmune disease. Inflammation of the joints results in the destruction of cartilage and bone early in the course of the disease. Although the pathogenesis ... IL-32β. Therefore IL-32β had effects on macrophages rather on than T cells in vivo, and the in vivo roles of IL-32β were mainly to induce other inflammatory cytokines rather than to activate the...

Ngày tải lên: 09/08/2014, 08:23

... compared the expression of the L1 ele- ment to that of the surrounding CD38 gene. We found that, while the abundance of the CD38 transcript is several orders of magnitude higher, the pattern of expression ... action of the RB1 promoter itself contributes directly to regulation of the L1. Instead, we hypothesize that transcription of RB1 results in the creation of a region of open chromatin that facilitates ... RACE adaptor. (c) Histogram depicting the distribution of polyadenylation positions of 3' expression tags, relative to the end of the L1. (d) Histogram depicting distribution of 5'...

Ngày tải lên: 09/08/2014, 20:20

... ET had full access to all of the study data and takes responsibility for the integrity of the data and the accuracy of the data analysis. Both authors contributed equally to the study. Study concept ... hours postoperatively. Their findings suggested that perioperative hyperoxia was not effective in reducing SSIs. These report s add to the evidence base surrounding the potential role of high FIO 2 in ... used to define SSIs. The SPSS software package (version 15) was used for statistical analysis. A p ≤ 0.05 was considered significant. To assess risk factors for SSI, we used one-way analysis of...

Ngày tải lên: 10/08/2014, 09:23

... selection bias due to the nat- ure of retrospective data. Also, our study was limi ted by the small number of patients, the heterogeneity of the disease, the transplant procedure and the stem cell source. ... prior history of cGVHD (p = .039). The 5-year survival rates of patients with intermediate & prior history of cGVHD +, poor & prior history of cGVHD +, and poor & prior history of cGVHD ... classified patients accordi ng to signifi- cant pre-transplant factors including poor -risk cytoge- netics, number of BM blasts, or secondary leukemia and their prior history of cGVHD at 6 months post-trans- plant....

Ngày tải lên: 10/08/2014, 10:21

Ngày tải lên: 12/08/2014, 14:20

Ngày tải lên: 12/08/2014, 15:20

Ngày tải lên: 11/08/2014, 12:20

... and LNCaP cell growth adds to the strength of evidence. While the evidence linking the effects of diet and lifestyle on the development and progression of prostate cancer is not conclusive, it is ... Cardiovascular disease is the leading cause of death of men and women in the United States and either the primary or secondary cause of death of most men with prostate cancer, and obesity is of widespread ... lifestyle may reduce the risk of prostate cancer and may affect its rate of progression. Since there is a significant rate of recurrence following any conventional treatment for prostate cancer, our findings...

Ngày tải lên: 29/03/2014, 01:20

... looting of the Sic‡n tombs, no other assemblage of this type is known to have survived the melting-pot fate of most of the stolen arti- facts. The Sic‡ns ßourished before the Incas, from A.D. 700 to ... crest of a CDW being stuck at a de- fect. If we move the CDW, the marble climbs over the edge of the eggcup and falls into the next one, which means that the next crest of the CDW gets stuck at the ... the Anthropological Society of Washington, showed that the work of Ramon y Cajal and others indi- cated that protoplasm is not merely the physical basis of life, but is the physi- cal basis of...

Ngày tải lên: 12/05/2014, 14:54

... Apatone, Cancer Introduction The PSA era has led to a stage migration in the clinical course of prostate cancer. While this success has dramatically lowered the death rate from prostate cancer, ... marrow toxicity, changes in organ weight or pathologic changes of these organs. 9 The purpose of this study was to evaluate the safety and efficacy of oral Apatone administered throughout the ... 6.58 Increased Following the 12 week trial, 15 of 17 patients opted to continue Apatone therapy. Any decision to remain on Apatone therapy was left entirely to the patient. Anecdotally,...

Ngày tải lên: 08/08/2014, 17:20

Ngày tải lên: 10/08/2014, 22:21

Ngày tải lên: 14/08/2014, 19:22

Ngày tải lên: 05/09/2013, 10:15

... [16]. They divided the contact per- sons into 3 groups. The first group consisted of close family and friends, the second of classmates and teachers and the third of more distant contacts. They ... All of the contacts were comprised of household contacts. Household contacts included spou- se, child, mother-father, brother/sister and other parents ORIGINAL ARTICLE Tuberculosis Risk Factors ... between TST positivity of contacts and gender, age, closeness to the index case, BCG scar presence and radiological degree of the disease of in- dex case. The rate of TST positivity of household contacts under...

Ngày tải lên: 29/03/2014, 03:20

... ability to replicate for extended periods of Table 2 Overview of risk factors and risks associated with stem cell-based therapy Risk factors or hazards Identified risks Intrinsic factors - Origin of ... multiple factors may contribute to tumour formation the risk of tumour formation will be disc ussed along the lines of these individual factors that are discussed in separate paragraphs. Second are the risks ... potential risks and risk factors obtained with other/existing stem cell based medicinal products may contribute to the risk evaluation of new stem cell based therapies. The potential risk of tumour...

Ngày tải lên: 18/06/2014, 19:20