anti histone antibodies in systemic lupus erythematosus
Báo cáo y học: "Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies" pdf
... play a role in downregulating anti- snRNP autoantibodies This may sound strange since most previous studies were focused on the role of viruses in inducing or enhancing autoantibodies in SLE [3]; ... cytomegalovirus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics aInformation for treatment was available in 19 patients in this group ... The Mexican Systemic Lupus Erythematosus Disease Activity Index and the Systemic Lupus International Collaborating Clinics/American Collage of Rheumatology Damage Indexes at the beginning of the...
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Báo cáo y học: "Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies" docx
... other autoantibodies studied Anti- Ro, anti- Ro52, anti- La, anti- CL, anti- P (P0, P1, P2), and anti- β2-GPI ELISA kits were obtained from Diamedix (Miami, FL, USA) Anti- dsDNA and anti- nucleosome antibodies ... others, antineuronal, antiphospholipid, antiganglioside, and anti- ribosomal P protein (anti- P) antibodies [reviewed [12]] However, particularly regarding psychiatric syndromes, conflicting results ... No significant correlation was found between anti- CL, anti 2-GPI, anti- dsDNA, anti- Ro, anti- Ro52, anti- La, anti- P, anti- nucleosome, or anti- GFAP antibodies and the presence of psychiatric disorders...
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Báo cáo y học: "Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus" pps
... Figure lacking the C-terminal 22-amino recombinant ribosomal P0 protein Cerebrospinal fluid antibodies toacid sequence lacking the C-terminal 22-amino acid sequence Antibodies to recombinant ribosomal ... the involvement of anti- NMDA receptor antibodies in diffuse NPSLE and to explore its relationship with anti- N A number of studies have indicated that serum anti- ribosomal P protein antibodies, including ... the incubation, CSF samples were recovered and were examined for anti- whole P, anti- PC22, anti- PEX.C22, and anti- N as described in Materials and methods Anti- N, anti- neuronal cell antibodies; anti- PC22,...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... homogeneous antinuclear antibodies characterized as anti- DNA antibodies At the time of splenectomy the patient had detectable antibodies against DNA (Crithidia negative), and IgA and IgM antibodies against ... from a patient with systemic lupus erythematosus (a) Anti- FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... produced anticardiolipin antibodies, but not anti- dsDNA, although there is no direct evidence that the cardiolipin antibodies used VH5-51 because no information about the specificity of these antibodies...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30...
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Báo cáo y học: "Cytokines in systemic lupus erythematosus, London, UK" ppt
... anti- IL-10 antibodies ameliorate disease in murine models of SLE In a small clinical trial, 21 daily doses of intravenous monoclonal murine anti- IL-10 antibody led to a clinical improvement in ... Isenberg DA: The effect of interleukin-10 and interleukin-12 on the in- vitro production of antidouble-stranded DNA antibodies from patients with systemic lupus erythematosus Clin Exp Immunol 2001, ... meeting showed the breadth of interest in the role played by different cytokines in SLE A large amount of work in mice, and a smaller body of evidence on the effects of anticytokine antibodies in...
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Báo cáo y học: "Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus" potx
... cytokine interleukin-6 Biochem Pharmacol 2000, 60:1185-1195 33 Cross JT, Benton HP: The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus Inflamm ... properties may explain why TNF blockade can induce increases in antinuclear antibodies and at the same time rapidly reduce inflammation and prevent inflammation-induced damage, also observed in SLE patients ... 1997, 24:303-308 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin-15 is elevated in systemic lupus erythematosus Rheumatology...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 1962, ... cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus Curr ... factors of carotid plaque in women with systemic lupus erythematosus Arthritis Rheum 1999, 42:51-60 Salmon JE, Roman MJ: Accelerated atherosclerosis in systemic lupus erythematosus: implications...
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Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx
... levels of anti- nucleosome antibodies (r = 0.0136), indicating that anti- CRP does not reflect antibodies against nucleosomes (not shown) Furthermore, preincubation of anti- nucleosome antibody-positive ... protein (CRP) and monomeric CRP (mCRP) considering the ability to inhibit anti- CRP binding, indicating that anti- CRP autoantibodies are targeted to the monomeric form of the acute-phase protein ... CRP include binding to, and clearing from the circulation, chromatin, nucleosomes and snRNPs [4,21,22]; that is, nuclear antigens to which antinuclear antibodies are commonly targeted [15] Binding...
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Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt
... [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer After washing three times with PBS, cells were incubated for hour ... then incubated for 30 at 25°C in the blocking buffer (2% bovine serum albumin in PBS, containing 5% glycerol and 0.2% Tween-20) Apoptosis was evaluated by propidium iodide staining, according ... clinical importance and may be a valuable tool in the diagnosis of neuropsychiatric SLE In addition, having this recombinant antigen may help in defining the precise role that specific autoantibodies...
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Báo cáo y học: "B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels" ppsx
... prevalence of anti- BLyS autoantibodies, because some of these autoantibodies may be saturated in vivo with circulating BLyS, rendering them incapable of binding to BLyS in the in vitro detection ... detecting antibodies in the in vitro ELISA In this case, measured BLyS levels would have been spuriously reduced, again masking BLyS overproduction In our cohort, IgA/IgM/IgG anti- BLyS antibodies ... 20:829-833 Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus Clin Exp Immunol 1979, 35:76-88 Klinman DM,...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... Specifically, antinuclear antibodies (ANAs), antibodies to double stranded (ds)DNA and anticardiolipin (ACL) were measured ANAs were measured by indirect immunofluorescence on Hep2 cells Antibodies ... et al.: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum 1997, ... of interleukin-2 and transforming growth factor-beta Lupus 1999, 8:95-102 Bruce IN, Gladman DD, Urowitz MB: Premature atherosclerosis in systemic lupus erythematosus Rheum Dis Clin North Am 2000,...
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Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf
... not be acceptable for use in SLE Another curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the overall clinical response rate above ... is only limited preclinical information available on the signaling mediated by epratuzumab binding to CD22 on various subsets of B cells [9] Several monoclonal antibodies against mouse CD22 have ... of using these reagents in mouse SLE models have appeared In our own unpublished experience, we have found that at least two of the anti- mouse CD22 monoclonal antibodies not deplete B cells in...
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Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases" pps
... mutations inhibit autoantibody production in pristane-induced lupus J Immunol 2000, 165:1036-1043 Rubin RL: Enzyme-linked immunosorbent assay for anti- DNA and antihistone antibodies including anti- (H2A-H2B) ... with the recombinant RPA32 protein Antibodies against RPA32 were found in 10.9% (87 of 801) in breast cancer patients and in 10.3% (4 of 39) in intraductal in situ carcinoma patients, in contrast ... with antiaminoacyl tRNA synthetase antibodies have antibodies against only one of the synthetases, and other patients have anti- SRP, anti- PM-Scl, anti- Ku, and anti- nRNP [31] Several autoantibodies...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" ppsx
... specifically induces inflammation in LE lesions Binding of autoantibodies to apoptotic keratinocytes in the skin and subsequent pro-inflammatory clearance by macrophages could be involved in induction ... inflammatory lesions in the vicinity of sunburn cells (SBCs) in patients with systemic lupus erythematosus (SLE) Haepatients with systemic lupus erythematosus (SLE) matoxylin eosin (H&E)-stained ... biopsy showing CD68 staining combined with haematoxylin staining using diaminobenzidine (DAB) for visualisation of CD68-positive cells Magnification, ×400 Two macrophages that contain multiple...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" pot
... USA) Anti- mouse and anti- rabbit IgG secondary antibodies were purchased from Cell Signaling Technology, Inc (Beverly, MA, USA) Rabbit anti- PUMA polyclonal antibody was purchased from ProSci, Inc ... Affinity-purified rabbit polyclonal anti- p53 (for immunohistochemistry), mouse monoclonal anti- p53 (for Western blotting), and rabbit polyclonal antibodies against p21 and hemagglutinin (HA) were purchased ... then washed and stained with biotinylated secondary antibody anti- mouse or anti- rabbit IgG and Vectastain ABC and developed with diaminobenzidine (Vector, Burlingame, CA, USA) Cell viability and...
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Báo cáo y học: "Neuropsychological patterns in systemic lupus erythematosus patients with depression" potx
... impaired working memory during major depression J Affect Disord 2006, 90:149-161 Denburg SD, Denburg JA: Cognitive dysfunction in systemic lupus erythematosus In Systemic Lupus Erythematosus ... lupus erythematosus In Systemic Lupus Erythematosus 2nd edition Edited by: Lahita RG New York, NY: Churchill Livingstone, Inc; 1992:639-655 West SG: Neuropsychiatric lupus Rheum Dis Clin North ... etiology of psychiatric symptoms in patients with systemic lupus erythematosus Scand J Rheumatol 1994, 23:277-282 Iverson GL: Screening for depression in systemic lupus erythematosus with the British...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... observed increases in autoantibodies to histones and/or chromatin in all seven patients, including those without anti- dsDNA antibodies [62] At least in part, the increase in anti- histone and anti- chromatin ... blockade with infliximab induced an increase of autoantibodies in five out of seven patients and increases in anti- cardiolipin -antibodies (ACLAs) in four out of seven patients in our open-label ... patients with anti- dsDNA antibodies as measured by radioimmunoassay ACLA, anti- cardiolipin antibodies; ANA, anti- nuclear antibodies; anti- dsDNA, antibodies to double-stranded DNA; AS, ankylosing spondylitis;...
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Báo cáo y học: "Role of resistin as a marker of inflammation in systemic lupus erythematosus" ppsx
... phosphate-buffered saline were introduced into the parallel strips coated with capture polyclonal antiresistin antibodies Biotin-labelled anti- resistin antibodies, streptavidin-horseradish peroxidase ... Dyslipoproteinemias in systemic lupus erythematosus: influence of disease, activity, and anticardiolipin antibodies Lupus 1997, 6:533-539 28 Kashef S, Ghaedian MM, Rajaee A, Ghaderi A: Dyslipoproteinemia ... immunoglobulin; PINP, N-terminal propeptide of type I procollagen; SD, standard deviation; sIL-6R, soluble interleukin-6 receptor; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus...
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Báo cáo y học: "Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis" ppsx
... crossreactivity between anticardiolipin and anti- oxLDL antibodies has been demonstrated [74] Additionally, beta2-glycoprotein I (β2GPI), the protein recognized by most antibodies to cardiolipin, binds directly ... lipoprotein and to cardiolipin in systemic lupus erythematosus Lancet 1993, 341:923-925 Aho K, Vaaral O, Tenkanen L, Julkunen H, Jouhikainen T, Alfthan G, Palusuo T: Antibodies binding to anionic ... normal HDLs Processes in addition to proinflammatory high-density lipoproteins that may accelerate atherosclerosis in systemic lupus erythematosus Antibodies may also play a role in the pathogenesis...
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- β1 in systemic lupus erythematosus
- kidney in systemic lupus erythematosus and vasculitis
- 3 epigenetic dysregulation in systemic lupus erythematosus
- assessment of disease activity in systemic lupus erythematosus
- cytokines in systemic lupus erythematosus
- autoantibodies in systemic lupus erythematosus
- role of complement in systemic lupus erythematosus pathogenesis
- immune complexes in systemic lupus erythematosus
- neutrophils polymorphonuclear leukocytes in systemic lupus erythematosus
- renal damage in systemic lupus erythematosus
- nitric oxide in systemic lupus erythematosus
- kidney involvement in systemic lupus erythematosus
- the lung in systemic lupus erythematosus
- gastrointestinal disease in systemic lupus erythematosus
- the nervous system in systemic lupus erythematosus
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