role of complement in systemic lupus erythematosus pathogenesis

... reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum 1997, 40:809-813 Cockcroft ... immunoglobulin; PINP, N-terminal propeptide of type I procollagen; SD, standard deviation; sIL-6R, soluble interleukin-6 receptor; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus ... resistin In multiple regression analyses, only BMD in radius remained associated with resistin Oh and colleagues [35] have shown an inverse correlation of resistin to BMD in lumbar spine in an...

Ngày tải lên: 09/08/2014, 10:22

... TNF often is a survival signal (green lines) and plays a role in maintaining survival niches for long-lived plasma cells (PlasmaC) Some of these effects are indirect in part, involving cytokines ... However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory response in SLE by administering only an induction regime of ... blockade with infliximab induced an increase of autoantibodies in five out of seven patients and increases in anti-cardiolipin-antibodies (ACLAs) in four out of seven patients in our open-label...

Ngày tải lên: 09/08/2014, 10:22

... in peripheral blood mononuclear cells from SLE patients and in kidneys of lupus mice with nephritis [20,21], suggesting that STAT1 may play a role in the pathogenesis of SLE A possible role of ... classification of systemic lupus erythematosus Arthritis Rheum 1997, 40:1725 23 Schildkraut JM: Examining complex genetic interactions In Approach to Gene Mapping in Complex Human Diseases Edited by: Haines ... biological responses Cytokine Growth Factor Rev 2000, 11:199-207 20 Baechler EC, Gregersen PK, Behrens TW: The emerging role of interferon in human systemic lupus erythematosus Curr Opin Immunol 2004,...

Ngày tải lên: 09/08/2014, 13:22

... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... because of difficulty in distinguishing between point mutations and junctional variation in this region of the variable gene because of recombination events Although mutations were seen in higher ... were located within the same 0.5 cm3 portion of spleen tissue GC A can be seen in Fig 1, and has two distinct areas of staining for FDC and one large area of B cells encompassing both FDC regions...

Ngày tải lên: 09/08/2014, 01:21

... of lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... the onset of systemic lupus erythematosus affect survival Br J Rheumatol 1998, 37:1008-1010 34 Aringer M, Steiner G, Graninger WB, Hofler E, Steiner CW, Smolen JS: Effects of short-term infliximab...

Ngày tải lên: 09/08/2014, 01:22

... Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus ... study of 65 patients treated with prednisolone Jpn J Med 1989, 28:599-603 Haider YS, Roberts WC: Coronary arterial disease in systemic lupus erythematosus; quantification of degrees of narrowing in ... and risk factors of carotid plaque in women with systemic lupus erythematosus Arthritis Rheum 1999, 42:51-60 Salmon JE, Roman MJ: Accelerated atherosclerosis in systemic lupus erythematosus: implications...

Ngày tải lên: 09/08/2014, 01:22

... Zoma A: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus Arthritis Rheum ... environmental, and infectious risk factors for developing systemic lupus erythematosus Arthritis Rheum 1998, 41:1714-1724 Robson MG, Walport MJ: Pathogenesis of systemic lupus erythematosus Clin Exp Allergy ... glomerulonephritis, often contrasting with levels of other acutephase reactants, might in fact be due to the consumption of CRP by ICs [35] With this in mind we find the high frequency (4 of 4) of anti-CRP in...

Ngày tải lên: 09/08/2014, 01:23

... indices are indirect measures of brain inflammation In contrast to a multitude of studies analyzing local inflammatory response in NPSLE, the evaluation of neuronal damage and the formation of ... brain lesions, both as compared with CSF findings of healthy controls as well as of lupus patients without MRI-verified brain pathology This finding, together with increased intrathecal levels of ... Chen MY, Wang GR, Lin KT, Chuang CY, Chen CY: The study of anticardiolipin antibodies and interleukin-6 in cerebrospinal fluid and blood of Chinese patients with systemic lupus erythematosus and...

Ngày tải lên: 09/08/2014, 01:23

... findings Despite an overall impressive amount of investigations, the pathogenesis of NPSLE is poorly understood Although a direct pathogenic role of autoantibodies in NPSLE through induction of ... Richardson EP: The neurological manifestations of systemic lupus erythematosus Medicine 1968, 47:337-369 Wekking EM: Psychiatric symptoms in systemic lupus erythematosus: an update Psychosom Med 1993, ... Valdes M, Font J, Ingelmo M: Psychiatric and psychosocial disorders in patients with systemic lupus erythematosus: a longitudinal study of active and inactive stages of the disease Lupus 2000, 9:584-588...

Ngày tải lên: 09/08/2014, 01:23

... iodide staining, according to the method of Nicoletti and colleagues [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer ... autoantigen in SLE This result is of clinical importance and may be a valuable tool in the diagnosis of neuropsychiatric SLE In addition, having this recombinant antigen may help in defining the ... the clinical associations AS participated in the analysis and interpretation of data and in the revision of the manuscript RR participated in the design of the study and in the revision of the...

Ngày tải lên: 09/08/2014, 06:23

... TGF-β1, a ratio of levels of TGF-β1 in freshly collected blood and after 90 minutes of clotting at 37°C was determined The degranulation of platelets during clotting results in release of excess latent ... O, et al.: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum ... difference in the type of LDL present in patients and control individuals may explain our observation of an inverse correlation of TGF-β1 AI and LDL in SLE patients, which was not seen in control individuals...

Ngày tải lên: 09/08/2014, 08:22

... Figure Development of infiltrates and inflammatory lesions in the vicinity of sunburn cells (SBCs) in patients with systemic lupus erythematosus (SLE) Haepatients with systemic lupus erythematosus ... LE lesions Binding of autoantibodies to apoptotic keratinocytes in the skin and subsequent pro-inflammatory clearance by macrophages could be involved in induction of infiltrates in our study ... staining), 10 mM citrate pH 6.0 (CD68 staining), or 10 mM Tris, mM EDTA pH 9.0 (CD3 staining) After washing in PBS, endogenous peroxidase was blocked by incubation in 0.37% H202 in PBS for 30 minutes...

Ngày tải lên: 09/08/2014, 08:22

... accumulation of cells in the lining can be due to ingress of cells from the blood, local proliferation, or insufficient deletion through apoptosis The latter is especially intriguing in view of the ... effectively induced apoptosis in FLS even in the presence of a dominant-negative p53 Discussion Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal ... K: Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer Gene Ther 1998, 5:331-338 Yao Q, Seol DW, Mi Z, Robbins PD: Intra-articular injection of recombinant TRAIL induces...

Ngày tải lên: 09/08/2014, 08:22

... AR: Nervous system involvement in systemic lupus erythematosus Ann Rheum Dis 1975, 35:398-406 Harris EN, Hughes GR: Cerebral disease in systemic lupus erythematosus Springer Semin Immunopathol 1985, ... antibodies in the serum of patients with systemic lupus erythematosus J Clin Invest 1976, 57:509-516 11 12 13 14 15 16 17 Wilson HA, Winfield JB, Lahita RG, Koffler D: Association of IgG anti-brain antibodies ... ribosomal P protein epitopes other than the C-terminal 22-amino acid sequence (anti-PEX.C22) in cerebrospinal fluid from patients with systemic lupus erythematosus (SLE), including 52 patients...

Ngày tải lên: 09/08/2014, 10:20

... Zoma A: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus Arthritis Rheum ... chemokine ligand; CXCL, C-X-C chemokine ligand; IFIG, IFN-inducible gene; IFIT, interferon-induced protein with tetratricopeptide repeats; IL, interleukin; IP-10, interferon-inducible protein 10; ... notably elevated in a subgroup of RA patients [27] but fails to identify any increase in the expression of IFN-inducible chemokines in RA, indicating that an elevated chemokine score might be...

Ngày tải lên: 09/08/2014, 13:22

... Kaplan M: Role of dendritic cells in the pathogenesis of systemic lupus erythematosus Future Rheumatol 2008, 3:269-280 21 Banchereau J, Pascual V: Type I interferon in systemic lupus erythematosus ... cell-specific intercellular adhesion molecule-grabbing tegrin expression in systemic lupus erythematosus dendritic cells Dendritic cell-specific intercellular adhesion molecule-grabbing noninnonintegrin ... generating and maintaining peripheral tolerance, a key component in the prevention of autoimmunity, as well as stimulating immune responses in appropriate settings [3] well as (in the case of the...

Ngày tải lên: 09/08/2014, 13:22

... of lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... the onset of systemic lupus erythematosus affect survival Br J Rheumatol 1998, 37:1008-1010 34 Aringer M, Steiner G, Graninger WB, Hofler E, Steiner CW, Smolen JS: Effects of short-term infliximab...

Ngày tải lên: 09/08/2014, 13:22

... SDI, Systemic Lupus International Collaborating Clinics Damage Index; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index aTwo patients were taking combined treatment with azathioprine ... O, Snaith M, Sturfelt G: The systemic lupus erythematosus international collaborating clinics/American College of Rheumatology index for systemic lupus erythematosus international comparison J ... Ramos-Casals M, Ingelmo M, Hughes GR, European Working Party on Systemic Lupus Erythematosus: Morbidity and mortality in systemic lupus erythematosus during a 10year period A comparison of early and...

Ngày tải lên: 09/08/2014, 14:22

... located in the vicinity of the synovial lining layer of rheumatoid arthritis patients while they were randomly distributed in PVNS [10] In addition, 20% of synoviocytes were aneuploid in diffuse PVNS ... responding to immunosuppressive therapy in lupus patients should raise suspicion of alternative diagnoses such as PVNS Page of Competing interests The authors declare that they have no competing interests ... patient the symptoms of PVNS clearly developed in a temporal association with a flareup of SLE and lupus nephritis We considered that Page of A B C Figure MRI of her right hip joint (A) The T1-weighted...

Ngày tải lên: 10/08/2014, 23:20

... functional analysis of CD4+ CD25– Foxp3+ T cells in patients with systemic lupus erythematosus J Immunol 2009, 182:1689-1695 Horwitz DA: Regulatory T cells in systemic lupus erythematosus: past, ... the staining intensity of the anti-CD25 conjugate used Another method to distinguish CD4+Foxp3+ Tregs from non-Tregs would be to examine the stability of Foxp3 expressed by these cells in culture ... cells and divided them into three distinctive populations based upon CD45RA expression and intensity of CD25 staining These included naïve CD45RA+CD25moderateFoxp3lo Treg resting precursor cells...

Ngày tải lên: 12/08/2014, 11:22