... physiological TGF -β1 activation during blood clotting in patients and control individuals, and examined whether TGF -β1 activation was associated with clinical phenotype, in particular inflammatory ... TGF -β1 in an in vitro assay that utilizes the physiological activation of latent TGF -β1 that occurs normally during blood clotting The activation of TGF -β1 during clotting is complex, being mediated ... [19,20] involving protease (plasmin) activation and interaction of TGF -β1 with thrombospondin-1 Using an ELISA assay validated for detection of active TGF -β1 [15,16], we determined the increased...
... from a patient with systemiclupuserythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... systemiclupuserythematosus Int Arch Allergy Immunol 2000, 123:36-45 27 de Wildt RMT, Tomlinson IM, van Venrooij WJ, Winter Ga, Hoet RMA: Comparable heavy and light chain pairings in normal and systemic ... complexes containing alkaline phosphatase/anti-alkaline phosphatase were detected by incubation with new fuschin substrate, and the sections were counter-stained with Mayer’s haematoxylin (Sigma)...
... Takeda T, Inoue T: Serum levels of interferons in patients with systemiclupuserythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30...
... The Mexican SystemicLupusErythematosus Disease Activity Index and the SystemicLupus International Collaborating Clinics/American Collage of Rheumatology Damage Indexes at the beginning of the ... cytomegalovirus; SLEDAI, SystemicLupusErythematosus Disease Activity Index; SLICC, SystemicLupus International Collaborating Clinics aInformation for treatment was available in 19 patients in this group ... particular interest in speculating that the binding of CMV DNA to TLR9 may interfere in the TLR7-dependent anti-snRNP autoantibody production Our findings suggest the potential role of CMV in regulation...
... disease in murine models of SLE In a small clinical trial, 21 daily doses of intravenous monoclonal murine anti-IL-10 antibody led to a clinical improvement in patients with SLE This was maintained ... antibodies insystemiclupuserythematosus J Rheumatol 1991, 18:230234 Lawman S, Ehrenstein MR: Many paths lead to lupusLupus 2002, 11:801-806 Ehrenstein MR, Cook HT, Neuberger MS: Deficiency in serum ... Isenberg DA: The effect of interleukin-10 and interleukin-12 on the in- vitro production of antidouble-stranded DNA antibodies from patients with systemiclupuserythematosus Clin Exp Immunol 2001,...
... Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement insystemiclupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 1962, ... cardiovascular risk factors insystemiclupuserythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern insystemiclupuserythematosus Curr ... factors of carotid plaque in women with systemiclupuserythematosus Arthritis Rheum 1999, 42:51-60 Salmon JE, Roman MJ: Accelerated atherosclerosis insystemiclupus erythematosus: implications...
... during infection, systemic inflammation or tissue damage [4] The family includes long pentraxins, such as pentraxin produced by mononuclear cells in response to lipopolysaccharide, interleukin-1β ... protein autoantibody; CRP, C-reactive protein; mSLEDAI, modified systemiclupuserythematosus disease activity index; n.s., not significant; SLEDAI, systemiclupuserythematosus disease activity index ... Zoma A: The development and initial validation of the SystemicLupus International Collaborating Clinics/American College of Rheumatology damage index for systemiclupuserythematosus Arthritis Rheum...
... OD All Available online http://arthritis-research.com/content/6/4/R366 Table Demographic and clinical findings in patients with systemiclupuserythematosus grouped according to their psychiatric ... Richardson EP: The neurological manifestations of systemiclupuserythematosus Medicine 1968, 47:337-369 Wekking EM: Psychiatric symptoms insystemiclupus erythematosus: an update Psychosom Med 1993, ... protein antibodies with CNS disease, excluding lupus psychosis [51] Interestingly, the ribosomal P protein P0 has been identified by molecular cloning strategy as an endothelial autoantigen in...
... [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer After washing three times with PBS, cells were incubated for hour ... then incubated for 30 at 25°C in the blocking buffer (2% bovine serum albumin in PBS, containing 5% glycerol and 0.2% Tween-20) Apoptosis was evaluated by propidium iodide staining, according ... staining was observed in cells treated with TNF-α plus cycloheximide (ii) These findings were confirmed in permeabilized cells Indeed, untreated control cells showed anti-Nedd5 staining confined...
... 20:829-833 Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells insystemiclupuserythematosus Clin Exp Immunol 1979, 35:76-88 Klinman DM, ... interpretation of the results, and in writing the final version of the manuscript DN assisted in the design in the study, in the interpretation of the results, and in writing the final version of the manuscript ... BLyS protein and anti-BLyS assays and assisted in the interpretation of the results and in writing the final version of the manuscript DMH assisted in the design in the study, in the interpretation...
... not be acceptable for use in SLE Another curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the overall clinical response rate above ... is only limited preclinical information available on the signaling mediated by epratuzumab binding to CD22 on various subsets of B cells [9] Several monoclonal antibodies against mouse CD22 have ... experience Competing interests RE has received support from Genentech for investigator and industry sponsored clinical trials, basic laboratory work and consultations regarding the development...
... with the recombinant RPA32 protein Antibodies against RPA32 were found in 10.9% (87 of 801) in breast cancer patients and in 10.3% (4 of 39) in intraductal in situ carcinoma patients, in contrast ... replication proteinA in some patients with systemiclupuserythematosus (SLE) Clin Exp Immunol 1996, 103:74-76 McNeilage LJ, Umapathysivam K, Macmillan E, Guidolin A, Whittingham S, Gordon T: Definition ... production in pristane-induced lupus J Immunol 2000, 165:1036-1043 Rubin RL: Enzyme-linked immunosorbent assay for anti-DNA and antihistone antibodies including anti-(H2A-H2B) In Manual of Clinical...
... lesions in the vicinity of sunburn cells (SBCs) in patients with systemiclupuserythematosus (SLE) Haepatients with systemiclupuserythematosus (SLE) matoxylin eosin (H&E)-stained paraffin sections ... staining), 10 mM citrate pH 6.0 (CD68 staining), or 10 mM Tris, mM EDTA pH 9.0 (CD3 staining) After washing in PBS, endogenous peroxidase was blocked by incubation in 0.37% H202 in PBS for 30 minutes ... specifically induces inflammation in LE lesions Binding of autoantibodies to apoptotic keratinocytes in the skin and subsequent pro-inflammatory clearance by macrophages could be involved in induction...
... effectively induced apoptosis in FLS even in the presence of a dominant-negative p53 Discussion Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal ... accumulation of cells in the lining can be due to ingress of cells from the blood, local proliferation, or insufficient deletion through apoptosis The latter is especially intriguing in view of the ... are either defective or minimally expressed in RA, including p53, sentrin [19], and PTEN (phosphatase and tensin homologue deleted on chromosome 10 [20] p53 is an interesting potential therapeutic...
... impaired working memory during major depression J Affect Disord 2006, 90:149-161 Denburg SD, Denburg JA: Cognitive dysfunction insystemiclupuserythematosusInSystemicLupusErythematosus ... lupuserythematosusInSystemicLupusErythematosus 2nd edition Edited by: Lahita RG New York, NY: Churchill Livingstone, Inc; 1992:639-655 West SG: Neuropsychiatric lupus Rheum Dis Clin North ... etiology of psychiatric symptoms in patients with systemiclupuserythematosus Scand J Rheumatol 1994, 23:277-282 Iverson GL: Screening for depression insystemiclupuserythematosus with the British...
... activity insystemiclupuserythematosus Clin Rheumatol 1999, 18:17-22 44 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin-15 ... life-threatening vascular complications [33,34] Tumor necrosis factor can deteriorate murine lupus Drug-induced lupus and lupus nephritis under tumor necrosis factor blockade In contrast to the findings in ... However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory response in SLE by administering only an induction...
... immunoglobulin; PINP, N-terminal propeptide of type I procollagen; SD, standard deviation; sIL-6R, soluble interleukin-6 receptor; SLE, systemiclupus erythematosus; SLEDAI, SystemicLupusErythematosus ... resistin and inflammation In our study, serum levels of creatinine remained a significant variable to resistin in the multiple regression analyses Whether this is due to high systemic inflammation ... resistin In multiple regression analyses, only BMD in radius remained associated with resistin Oh and colleagues [35] have shown an inverse correlation of resistin to BMD in lumbar spine in an...
... quartiles, the vertical lines show minimum and maximum values, and horizontal lines in each box indicate median values Note that inflammatory indices are higher in SLE patients than in healthy controls ... lipoprotein and to cardiolipin insystemiclupuserythematosus Lancet 1993, 341:923-925 Aho K, Vaaral O, Tenkanen L, Julkunen H, Jouhikainen T, Alfthan G, Palusuo T: Antibodies binding to anionic ... release proinflammatory cytokines and chemokines, causing local tissue damage and stimulating hypertrophy of smooth muscle cells in the artery wall Inflammation is also expanded by the influx Page...