3 epigenetic dysregulation in systemic lupus erythematosus

... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... systemic lupus erythematosus Int Arch Allergy Immunol 2000, 123:36-45 27 de Wildt RMT, Tomlinson IM, van Venrooij WJ, Winter Ga, Hoet RMA: Comparable heavy and light chain pairings in normal and systemic ... complexes containing alkaline phosphatase/anti-alkaline phosphatase were detected by incubation with new fuschin substrate, and the sections were counter-stained with Mayer’s haematoxylin (Sigma)...

Ngày tải lên: 09/08/2014, 01:21

... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30...

Ngày tải lên: 09/08/2014, 01:22

... The Mexican Systemic Lupus Erythematosus Disease Activity Index and the Systemic Lupus International Collaborating Clinics/American Collage of Rheumatology Damage Indexes at the beginning of the ... cytomegalovirus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics aInformation for treatment was available in 19 patients in this group ... particular interest in speculating that the binding of CMV DNA to TLR9 may interfere in the TLR7-dependent anti-snRNP autoantibody production Our findings suggest the potential role of CMV in regulation...

Ngày tải lên: 09/08/2014, 01:22

... disease in murine models of SLE In a small clinical trial, 21 daily doses of intravenous monoclonal murine anti-IL-10 antibody led to a clinical improvement in patients with SLE This was maintained ... antibodies in systemic lupus erythematosus J Rheumatol 1991, 18:230234 Lawman S, Ehrenstein MR: Many paths lead to lupus Lupus 2002, 11:801-806 Ehrenstein MR, Cook HT, Neuberger MS: Deficiency in serum ... Isenberg DA: The effect of interleukin-10 and interleukin-12 on the in- vitro production of antidouble-stranded DNA antibodies from patients with systemic lupus erythematosus Clin Exp Immunol 2001,...

Ngày tải lên: 09/08/2014, 01:22

... the inflammatory cytokine interleukin-6 Biochem Pharmacol 2000, 60:1185-1195 33 Cross JT, Benton HP: The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus ... 1997, 24:303-308 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin-15 is elevated in systemic lupus erythematosus Rheumatology ... DC-poietins in systemic lupus erythematosus Hum Immunol 2002, 63:1172-1180 47 Scheinecker C, Zwolfer B, Koller M, Manner G, Smolen JS: Alterations of dendritic cells in systemic lupus erythematosus: ...

Ngày tải lên: 09/08/2014, 01:22

... Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 1962, ... cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus Curr ... factors of carotid plaque in women with systemic lupus erythematosus Arthritis Rheum 1999, 42:51-60 Salmon JE, Roman MJ: Accelerated atherosclerosis in systemic lupus erythematosus: implications...

Ngày tải lên: 09/08/2014, 01:22

... during infection, systemic inflammation or tissue damage [4] The family includes long pentraxins, such as pentraxin produced by mononuclear cells in response to lipopolysaccharide, interleukin-1β ... protein autoantibody; CRP, C-reactive protein; mSLEDAI, modified systemic lupus erythematosus disease activity index; n.s., not significant; SLEDAI, systemic lupus erythematosus disease activity index ... Zoma A: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus Arthritis Rheum...

Ngày tải lên: 09/08/2014, 01:23

... OD All Available online http://arthritis-research.com/content/6/4/R366 Table Demographic and clinical findings in patients with systemic lupus erythematosus grouped according to their psychiatric ... Richardson EP: The neurological manifestations of systemic lupus erythematosus Medicine 1968, 47:337-369 Wekking EM: Psychiatric symptoms in systemic lupus erythematosus: an update Psychosom Med 1993, ... protein antibodies with CNS disease, excluding lupus psychosis [51] Interestingly, the ribosomal P protein P0 has been identified by molecular cloning strategy as an endothelial autoantigen in...

Ngày tải lên: 09/08/2014, 01:23

... [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer After washing three times with PBS, cells were incubated for hour ... then incubated for 30 at 25°C in the blocking buffer (2% bovine serum albumin in PBS, containing 5% glycerol and 0.2% Tween-20) Apoptosis was evaluated by propidium iodide staining, according ... staining was observed in cells treated with TNF-α plus cycloheximide (ii) These findings were confirmed in permeabilized cells Indeed, untreated control cells showed anti-Nedd5 staining confined...

Ngày tải lên: 09/08/2014, 06:23

... 20:829-833 Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus Clin Exp Immunol 1979, 35:76-88 Klinman DM, ... interpretation of the results, and in writing the final version of the manuscript DN assisted in the design in the study, in the interpretation of the results, and in writing the final version of the manuscript ... BLyS protein and anti-BLyS assays and assisted in the interpretation of the results and in writing the final version of the manuscript DMH assisted in the design in the study, in the interpretation...

Ngày tải lên: 09/08/2014, 07:20

... et al.: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum 1997, ... transforming growth factor-beta Lupus 1999, 8:95-102 Bruce IN, Gladman DD, Urowitz MB: Premature atherosclerosis in systemic lupus erythematosus Rheum Dis Clin North Am 2000, 26:257-278 Grainger ... SLE, systemic lupus erythematosus; TGF, transforming growth factor A relative Activation Index (AI) was calculated, by division of TGF-β1 levels in blood (A450) incubated at 37°C for 90 minutes...

Ngày tải lên: 09/08/2014, 08:22

... not be acceptable for use in SLE Another curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the overall clinical response rate above ... is only limited preclinical information available on the signaling mediated by epratuzumab binding to CD22 on various subsets of B cells [9] Several monoclonal antibodies against mouse CD22 have ... experience Competing interests RE has received support from Genentech for investigator and industry sponsored clinical trials, basic laboratory work and consultations regarding the development...

Ngày tải lên: 09/08/2014, 08:22

... with the recombinant RPA32 protein Antibodies against RPA32 were found in 10.9% (87 of 801) in breast cancer patients and in 10.3% (4 of 39) in intraductal in situ carcinoma patients, in contrast ... replication proteinA in some patients with systemic lupus erythematosus (SLE) Clin Exp Immunol 1996, 103:74-76 McNeilage LJ, Umapathysivam K, Macmillan E, Guidolin A, Whittingham S, Gordon T: Definition ... production in pristane-induced lupus J Immunol 2000, 165:1036-1043 Rubin RL: Enzyme-linked immunosorbent assay for anti-DNA and antihistone antibodies including anti-(H2A-H2B) In Manual of Clinical...

Ngày tải lên: 09/08/2014, 08:22

... lesions in the vicinity of sunburn cells (SBCs) in patients with systemic lupus erythematosus (SLE) Haepatients with systemic lupus erythematosus (SLE) matoxylin eosin (H&E)-stained paraffin sections ... staining), 10 mM citrate pH 6.0 (CD68 staining), or 10 mM Tris, mM EDTA pH 9.0 (CD3 staining) After washing in PBS, endogenous peroxidase was blocked by incubation in 0.37% H202 in PBS for 30 minutes ... specifically induces inflammation in LE lesions Binding of autoantibodies to apoptotic keratinocytes in the skin and subsequent pro-inflammatory clearance by macrophages could be involved in induction...

Ngày tải lên: 09/08/2014, 08:22

... effectively induced apoptosis in FLS even in the presence of a dominant-negative p53 Discussion Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal ... accumulation of cells in the lining can be due to ingress of cells from the blood, local proliferation, or insufficient deletion through apoptosis The latter is especially intriguing in view of the ... are either defective or minimally expressed in RA, including p53, sentrin [19], and PTEN (phosphatase and tensin homologue deleted on chromosome 10 [20] p53 is an interesting potential therapeutic...

Ngày tải lên: 09/08/2014, 08:22

... AR: Nervous system involvement in systemic lupus erythematosus Ann Rheum Dis 1975, 35:398-406 Harris EN, Hughes GR: Cerebral disease in systemic lupus erythematosus Springer Semin Immunopathol 1985, ... Figure lacking the C-terminal 22-amino recombinant ribosomal P0 protein Cerebrospinal fluid antibodies toacid sequence lacking the C-terminal 22-amino acid sequence Antibodies to recombinant ribosomal ... recombinant ribosomal P0 protein lacking the C-terminal 22-amino acid sequence (anti-C22depleted rP0) (c) with anti-neuronal cell antibodies (anti-N) in cerebrospinal fluid from systemic lupus erythematosus...

Ngày tải lên: 09/08/2014, 10:20

... impaired working memory during major depression J Affect Disord 2006, 90:149-161 Denburg SD, Denburg JA: Cognitive dysfunction in systemic lupus erythematosus In Systemic Lupus Erythematosus ... lupus erythematosus In Systemic Lupus Erythematosus 2nd edition Edited by: Lahita RG New York, NY: Churchill Livingstone, Inc; 1992:639-655 West SG: Neuropsychiatric lupus Rheum Dis Clin North ... etiology of psychiatric symptoms in patients with systemic lupus erythematosus Scand J Rheumatol 1994, 23:277-282 Iverson GL: Screening for depression in systemic lupus erythematosus with the British...

Ngày tải lên: 09/08/2014, 10:20

... activity in systemic lupus erythematosus Clin Rheumatol 1999, 18:17-22 44 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin-15 ... life-threatening vascular complications [33,34] Tumor necrosis factor can deteriorate murine lupus Drug-induced lupus and lupus nephritis under tumor necrosis factor blockade In contrast to the findings in ... However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory response in SLE by administering only an induction...

Ngày tải lên: 09/08/2014, 10:22

... immunoglobulin; PINP, N-terminal propeptide of type I procollagen; SD, standard deviation; sIL-6R, soluble interleukin-6 receptor; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus ... resistin and inflammation In our study, serum levels of creatinine remained a significant variable to resistin in the multiple regression analyses Whether this is due to high systemic inflammation ... resistin In multiple regression analyses, only BMD in radius remained associated with resistin Oh and colleagues [35] have shown an inverse correlation of resistin to BMD in lumbar spine in an...

Ngày tải lên: 09/08/2014, 10:22

... quartiles, the vertical lines show minimum and maximum values, and horizontal lines in each box indicate median values Note that inflammatory indices are higher in SLE patients than in healthy controls ... lipoprotein and to cardiolipin in systemic lupus erythematosus Lancet 1993, 341:923-925 Aho K, Vaaral O, Tenkanen L, Julkunen H, Jouhikainen T, Alfthan G, Palusuo T: Antibodies binding to anionic ... release proinflammatory cytokines and chemokines, causing local tissue damage and stimulating hypertrophy of smooth muscle cells in the artery wall Inflammation is also expanded by the influx Page...

Ngày tải lên: 09/08/2014, 10:23