assessment of disease activity in systemic lupus erythematosus

... protein autoantibody; CRP, C-reactive protein; mSLEDAI, modified systemic lupus erythematosus disease activity index; n.s., not significant; SLEDAI, systemic lupus erythematosus disease activity index ... autoantibody-inducing T cells of lupus J Exp Med 1993, 177:1367-1381 Spronk PE, Limburg PC, Kallenberg CGM: Serological markers of disease activity in systemic lupus erythematosus Lupus 1995, ... Zoma A: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus Arthritis Rheum...

Ngày tải lên: 09/08/2014, 01:23

... hematologic activity Thus, free protein S may be useful as a biomarker of clinical phenotype and disease activity Furthermore, the decrease of protein S and increase of Gas6 in patients with acute activity ... SLEDAI, Systemic Lupus Erythematosus Disease Activity Index intra-assay and inter-assay coefficient of variation (CV) were 4.52% and 11.8%, respectively Measurement of plasma free protein S concentrations ... 48% amino acid identity to protein S, was discovered in the early 1990 s [15] It contains an N-terminal g-carboxyglutamic acid (Gla) domain, interacting with phosphatidylserine containing membranes,...

Ngày tải lên: 12/08/2014, 14:22

... study of 65 patients treated with prednisolone Jpn J Med 1989, 28:599-603 Haider YS, Roberts WC: Coronary arterial disease in systemic lupus erythematosus; quantification of degrees of narrowing in ... Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus ... induced in it by corticosteroid therapy A study of 36 necropsy patients Am J Med 1975, 58: 243-264 Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: ...

Ngày tải lên: 09/08/2014, 01:22

... classification of systemic lupus erythematosus Arthritis Rheum 1997, 40:1725 23 Schildkraut JM: Examining complex genetic interactions In Approach to Gene Mapping in Complex Human Diseases Edited by: Haines ... disequilibrium plot of of STAT1-STAT4 region in a Japanese population and Linkage(SNPs) first screening the52 tag single nucleotide polymorpopulation and first screening of 52 tag single nucleotide ... accelerated nephritis and increased mortality in the absence of high levels of autoantibodies [25] STAT4 has been shown to be involved in the induction of IFNγ, differentiation of Th1 and Th17 cells,...

Ngày tải lên: 09/08/2014, 13:22

... SDI, Systemic Lupus International Collaborating Clinics Damage Index; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index aTwo patients were taking combined treatment with azathioprine ... n/N (%) or median (range) SDI, Systemic Lupus International Collaborating Clinics Damage Index; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index Page of (page number not for citation ... O, Snaith M, Sturfelt G: The systemic lupus erythematosus international collaborating clinics/American College of Rheumatology index for systemic lupus erythematosus international comparison J...

Ngày tải lên: 09/08/2014, 14:22

... found an overlapping pattern of proliferating macrophages and fibroblasts [10] CD68/CD163+ synoviocytes were preferentially located in the vicinity of the synovial lining layer of rheumatoid arthritis ... potential role of estrogens which clearly contribute to onset and disease activity of SLE while an association of estrogens and PVNS remains speculative [9] Furthermore, SLE remains a recurrent disease ... immunosuppressive therapy in lupus patients should raise suspicion of alternative diagnoses such as PVNS Page of Competing interests The authors declare that they have no competing interests Received:...

Ngày tải lên: 10/08/2014, 23:20

... tyrosine kinase) which is involved in BCR signaling, but also in the regulation of integrin activation [44] Moreover, recent work indicates that Syk is involved in CXCL12- and a4b1 integrin-induced ... T-cells since high expression of a4b1 integrin resulted in a loss of a4b7 integrin With this in mind, subsequent studies were performed to analyze whether down-modulation of b7 integrin on the ... phosphate-buffered saline; PE: phycoerythrin; PE-Cy7: phycoerythrin-cyanin 7; PerCP: peridin chlorophyll protein; Siglec-2: Sialic acid-binding Ig-like lectin 2; SLE: systemic lupus erythematosus; SyK:...

Ngày tải lên: 12/08/2014, 15:21

... especially within the context of specific autoimmune diseases The findings of such studies will shed new light on the dysregulation of the immune system and the involvement of inflammation in the initiation ... Zoma A: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus Arthritis Rheum ... Association of chemokine and IFN scores with disease activity in SLE patients Each symbol represents an individual patient; horizontal lines indicate and IFN scores with disease activity in SLE patients...

Ngày tải lên: 09/08/2014, 13:22

... engulfment of the apoptotic cell [30,31] The process requires that the Mer is an intact membranespanning protein and depends on activation of the intracellular kinase domain of Mer The presence of fluid ... early as possible Possibly, determination of sMer concentration can be helpful in the evaluation of SLE disease activity in general and, in particular, ongoing renal inflammation Conclusions We demonstrate ... participated in the analysis of experimental data and in the writing of the manuscript AJ, GS, AAB, AG, BL, EL and TS participated in the design of the study, in the analysis of the patient cohorts, in...

Ngày tải lên: 12/08/2014, 15:23

... and in writing the final version of the manuscript DMH assisted in the design in the study, in the interpretation of the results, and in writing the final version of the manuscript DN assisted in ... underestimates of the true prevalence of anti-BLyS autoantibodies, because some of these autoantibodies may be saturated in vivo with circulating BLyS, rendering them incapable of binding to BLyS in the in ... 20:829-833 Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus Clin Exp Immunol 1979, 35:76-88 Klinman DM,...

Ngày tải lên: 09/08/2014, 07:20

... model of lupus- prone mice fed high-fat chow or administered leptin had accelerated and increased proteinuria, suggesting an interplay between diet and lupus [68] Certainly, some murine lupus ... plaqueresiding CD4+ T cells to increase TNF-related apoptosisinducing ligand (TRAIL) expression, which results in killing of plaque stabilizing cells and a potential increase in the risk of plaque ... crucial that future clinical trials in SLE include biomarkers of vascular damage, functional studies of vascular health and assessment of subclinical and clinical CVD as endpoints in their efficacy analysis...

Ngày tải lên: 12/08/2014, 15:22

... deviation; SLE: systemic lupus erythematosus; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; SLICC/ACR DI: Systemic Lupus Erythematosus International Collaborating Clinics / American ... describing changes in disease activity in Systemic Lupus Erythematosus J Rheumatol 2000, 27:377-379 13 Ibanez D, Gladman DD, Urowitz MB: Adjusted mean Systemic Lupus Erythematosus Disease Activity Index-2K ... consideration in future studies of dynamic risk factors for CAD in a chronic relapsing-remitting disease such as SLE Our findings also underpin the importance of adequate control of SLE disease activity...

Ngày tải lên: 12/08/2014, 18:20

... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... because of difficulty in distinguishing between point mutations and junctional variation in this region of the variable gene because of recombination events Although mutations were seen in higher ... were located within the same 0.5 cm3 portion of spleen tissue GC A can be seen in Fig 1, and has two distinct areas of staining for FDC and one large area of B cells encompassing both FDC regions...

Ngày tải lên: 09/08/2014, 01:21

... of lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... E, Hahn BH, Tsao BP: Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus Arthritis Rheum 2006,...

Ngày tải lên: 09/08/2014, 01:22

... cytokine interleukin-6 Biochem Pharmacol 2000, 60:1185-1195 33 Cross JT, Benton HP: The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus Inflamm ... 1997, 24:303-308 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin-15 is elevated in systemic lupus erythematosus Rheumatology ... correlation again suggests involvement of TNF in the inflammatory and destructive process of the disease These data are further supported by the finding that infliximab significantly reduced proteinuria,...

Ngày tải lên: 09/08/2014, 01:22

... iodide staining, according to the method of Nicoletti and colleagues [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer ... were not statistically significant SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index (47%) of 17, vs (17%) of 34, P = 0.045 on the Fisher exact test) ... autoantigen in SLE This result is of clinical importance and may be a valuable tool in the diagnosis of neuropsychiatric SLE In addition, having this recombinant antigen may help in defining the...

Ngày tải lên: 09/08/2014, 06:23

... underwent a full clinical assessment, including measurement of disease activity using the SLE Disease Activity Index (SLEDAI) [12] Therapy was recorded, including current dose of steroids and antimalarial ... TGF-β1, a ratio of levels of TGF-β1 in freshly collected blood and after 90 minutes of clotting at 37°C was determined The degranulation of platelets during clotting results in release of excess latent ... index (low TGF-β1 AI linked with high level of apoptosis) The significance of increased PBMC apoptosis in SLE is profound, possibly reflecting increased levels of cells undergoing activated induced...

Ngày tải lên: 09/08/2014, 08:22

... lesions in the vicinity of sunburn cells (SBCs) in patients with systemic lupus erythematosus (SLE) Haepatients with systemic lupus erythematosus (SLE) matoxylin eosin (H&E)-stained paraffin sections ... scores of dermal influx of infiltrating cells in H&Estained sections and the morphometric scores of either CD3or CD68-stained OK sections were increased (> mean + two SDs of controls) in biopsies ... staining), 10 mM citrate pH 6.0 (CD68 staining), or 10 mM Tris, mM EDTA pH 9.0 (CD3 staining) After washing in PBS, endogenous peroxidase was blocked by incubation in 0.37% H202 in PBS for 30 minutes...

Ngày tải lên: 09/08/2014, 08:22

... accumulation of cells in the lining can be due to ingress of cells from the blood, local proliferation, or insufficient deletion through apoptosis The latter is especially intriguing in view of the ... effectively induced apoptosis in FLS even in the presence of a dominant-negative p53 Discussion Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal ... K: Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer Gene Ther 1998, 5:331-338 Yao Q, Seol DW, Mi Z, Robbins PD: Intra-articular injection of recombinant TRAIL induces...

Ngày tải lên: 09/08/2014, 08:22

... AR: Nervous system involvement in systemic lupus erythematosus Ann Rheum Dis 1975, 35:398-406 Harris EN, Hughes GR: Cerebral disease in systemic lupus erythematosus Springer Semin Immunopathol 1985, ... Differential reactivity of purified antibodies to the C-terminal 22 amino acids of ribosomal P protein Differential reactivity of purified antibodies to the C-terminal 22-amino acid sequence of ribosomal ... antibodies in the serum of patients with systemic lupus erythematosus J Clin Invest 1976, 57:509-516 11 12 13 14 15 16 17 Wilson HA, Winfield JB, Lahita RG, Koffler D: Association of IgG anti-brain antibodies...

Ngày tải lên: 09/08/2014, 10:20