kidney in systemic lupus erythematosus and vasculitis

... with the recombinant RPA32 protein Antibodies against RPA32 were found in 10.9% (87 of 801) in breast cancer patients and in 10.3% (4 of 39) in intraductal in situ carcinoma patients, in contrast ... single-stranded DNA-binding protein with multiple and essential roles in almost every aspect of DNA metabolism, including replication, repair, and recombination [6] Autoantibodies against RPA in rheumatic ... proteins and DNA by high NaCl and possibly secondary conformational changes help the binding of anti-RPA antibodies in autoimmune sera We examined whether the binding of DNA to RPA can interfere...

Ngày tải lên: 09/08/2014, 08:22

... release proinflammatory cytokines and chemokines, causing local tissue damage and stimulating hypertrophy of smooth muscle cells in the artery wall Inflammation is also expanded by the influx Page ... horizontal lines in each box indicate median values Note that inflammatory indices are higher in SLE patients than in healthy controls or RA patients and are higher in RA patients than in healthy ... platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid...

Ngày tải lên: 09/08/2014, 10:23

... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... with TA-cloning vector pCRII, and transformed into IFN-αF cells (Invitrogen, Paisley, UK) and cloned Immunohistochemical staining of tissue sections Frozen sections were stained using mouse monoclonal ... within close proximity, but B-cell staining shows no clear demarcation (c) Anti-FDC staining for GC B (d) staining with anti-CD20 Panels (a) and (b) are consecutive sections, as are (c) and (d)...

Ngày tải lên: 09/08/2014, 01:21

... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus patients...

Ngày tải lên: 09/08/2014, 01:22

... Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 1962, ... Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus ... perfusion abnormalities in women with SLE [abstract] Arthritis Rheum 1997, 40 (suppl):S219 Bulkley BH, Roberts WC: The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid...

Ngày tải lên: 09/08/2014, 01:22

... For annexin-V/PI staining × 106 cells were resuspended in 50 µl binding buffer (Roche Diagnostics, Lewes, UK) and incubated with annexin-V/FITC (Roche) and annexin-V/PI (Roche) for 15 minutes at ... TGF-β1 activation during blood clotting in patients and control individuals, and examined whether TGF-β1 activation was associated with clinical phenotype, in particular inflammatory disease ... difference in the type of LDL present in patients and control individuals may explain our observation of an inverse correlation of TGF-β1 AI and LDL in SLE patients, which was not seen in control individuals...

Ngày tải lên: 09/08/2014, 08:22

... potential in patients with SLE through cross-reactive α-actinin binding, we analysed the associations between α-actinin binding and clinical and immunological manifestations in patients with SLE in ... testing in general and puts the clinical significance of Abs to α-actinin in a broader perspective than prior studies Table Correlation between α-actinin-binding antibody levels and clinical findings ... as insignificant and epiphenomenological from insight into their origin and clinical impact and are in line with cutoff values adapted by other laboratories [43] Table Demographics and α-actinin...

Ngày tải lên: 09/08/2014, 08:23

... selected and collected samples and interpreted and provided clinical data WZ acquired data MW-H analysed and interpreted data and helped prepare the manuscript CT and VM participated in the study ... stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis Arthritis Rheum 2003, 48:982-992 30 Ronnblom L, Alm GV: Systemic lupus erythematosus and the type I interferon ... with systemic lupus erythematosus (SLE) (S5 and S14) representing the frequency relation of B-cell frequency (left y-axis in diagrams) and cytokine levels (right y-axis) of BAFF (top row) and...

Ngày tải lên: 09/08/2014, 08:23

... chemokine ligand; CXCL, C-X-C chemokine ligand; IFIG, IFN-inducible gene; IFIT, interferon-induced protein with tetratricopeptide repeats; IL, interleukin; IP-10, interferon-inducible protein 10; ... chemokine score was dramatically increased LN, lupus nephritis; SDI, Systemic Lupus International Collaborating Clinics/American Society of Rheumatology Damage Index; SLE, systemic lupus erythematosus ... age and sex ANA, antinuclear antibody; RA, rheumatoid arthritis; SDI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index; SLE, systemic lupus erythematosus; ...

Ngày tải lên: 09/08/2014, 13:22

... editors: The interaction of T cells with cells of the innate immune system and B cells in the pathogenesis of SLE In Dubois’ lupus erythematosus 7th edition New York: Lippincott Williams & Wilkins; 2007:133-160 ... for interleukin in Foxp3-expressing regulatory T cells Nat Immunol 2005, 6:1142-1151 β Marie JC, Letterio JJ, Gavin M, Rudensky AY: TGF-β1 maintains suppressor function and Foxp3 expression in ... Humrich J, Ebling FM, Hocher B, Humaljoki T, Neumayer H, Burmester GR, Hahn BH, Radbruch A, Hiepe F: Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type...

Ngày tải lên: 09/08/2014, 13:22

... cell-specific intercellular adhesion molecule-grabbing tegrin expression in systemic lupus erythematosus dendritic cells Dendritic cell-specific intercellular adhesion molecule-grabbing noninnonintegrin ... for generating and maintaining peripheral tolerance, a key component in the prevention of autoimmunity, as well as stimulating immune responses in appropriate settings [3] well as (in the case ... expression in systemic lupus erythematosus dendritic cells Dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIGN) expression is downregulated in unstimulated and stimulated...

Ngày tải lên: 09/08/2014, 13:22

... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus patients...

Ngày tải lên: 09/08/2014, 13:22

... enzyme is increased in level and activity in some inflammatory diseases and catalyzes hydrolysis of aminophospholipids, including PS, as well as phosphatidylcholine and phsophatidylethanolamine, all ... observed in other AIDs Interestingly, in severe pSS with extraglandular manifestations, the level of platelet MP was less increased than those in pSS patients with glandular involvement only In addition, ... B, Martin T, Bischoff P, Lill H, Pasquali JL, Freyssinet JM: The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection J Clin Invest 1997,...

Ngày tải lên: 09/08/2014, 14:22

... Infiltrates of IL-17 producing T cells, including CD4 + and DN T cells, have been found in lupus nephritis In addition, IL17 gene expression was detected in T cells infiltrating the kidneys and ... antibody-producing cells [25] Yet, it remains unknown why IL-17 production is increased in lupus and whether such a finding is related to Th1 cells producing IFN-g Determining the balance of Th17- and Th1-cell ... with SLE than in healthy subjects, suggesting the possible involvement of this cytokine in enhancing the Th17-cell response we observed In line with this finding, increased circulating levels of...

Ngày tải lên: 12/08/2014, 12:20

... systemic lupus erythematosus; SLEDAI: systemic lupus erythematosus disease activity index; TNF-α: tumor necrosis factor-α Competing interests The authors declare that they have no competing interests ... (lymphoid) and CD11c+ (myeloid) dendritic cells in systemic lupus erythematosus Clin Exp Immunol 2005, 142:84-91 Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A: Inflammatory stimuli induce ... dendritic cells in intestinal lamina propria to mesenteric lymph nodes J Immunol 2006, 176:803-810 43 Ronnblom L, Alm GV: The natural interferon-alpha producing cells in systemic lupus erythematosus...

Ngày tải lên: 12/08/2014, 12:20

... myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study Am J Epidemiol 1997, 145:408-415 Gladman DD, Urowitz MB: Morbidity in systemic lupus erythematosus ... TC, SBP, and DBP were included in the analysis Patients attending the University of Toronto lupus clinic are followed up at 2- to 6-month intervals, and clinical and laboratory data obtained at ... risk factors in SLE Second, identifying correlates of TC and BP in SLE aids in the selection of covariates and interaction terms for inclusion in multivariate models when the outcome of interest...

Ngày tải lên: 12/08/2014, 14:22

... tyrosine kinase) which is involved in BCR signaling, but also in the regulation of integrin activation [44] Moreover, recent work indicates that Syk is involved in CXCL12- and a4b1 integrin-induced ... a4b7 integrin is regulated in a homeostatic relation with the surface expression of a4b1 integrin on T-cells since high expression of a4b1 integrin resulted in a loss of a4b7 integrin With this in ... baseline and not substantially changed by epratuzumab The data indicate that b1 integrin and b7 integrin expression could be regulated interdependently on CD27 negative B-cells In addition, binding...

Ngày tải lên: 12/08/2014, 15:21

... model of lupus- prone mice fed high-fat chow or administered leptin had accelerated and increased proteinuria, suggesting an interplay between diet and lupus [68] Certainly, some murine lupus models ... Raggi P, Stein CM: Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis Lupus 2009, 18:799-806 53 Clancy R, Ginzler E: Endothelial ... metabolic syndrome and insulin resistance, and this correlates with increases in homocysteine and high sensitivity CRP [94] Treatment of insulin-resistant states may improve CVD profiles in SLE Our group...

Ngày tải lên: 12/08/2014, 15:22

... deposits in the kidneys initiates an inflammatory response by activating the complement cascade and recruiting inflammatory cells, and the resulting lupus nephritis is a severe complication in SLE ... severe inflammation, not have increased plasma levels of sMer These results stand in contrast to those obtained for Gas6 and sAxl In many different clinical conditions, including sepsis, CLI and ... yearly and radiographs of hands and feet were obtained in years to and year 10 The radiographs were evaluated for joint damage according to the Larsen scoring system [19,20] Analyses of sMer and...

Ngày tải lên: 12/08/2014, 15:23

... ATP6 and CYTB were found in rheumatoid arthritis (unpublished data) Moreover, it is interesting that proinflammatory cytokines such as IL-6 and TNF, as well as anti-inflammatory cytokines including ... of increased interferoninducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus Arthritis Rheum 2006, 54:2951-2962 Lee HM, Mima T, Sugino ... cross-complementing (ERCC)2, (b) ERCC5, and (c) X-ray repair cross-complementing (XRCC)6 in peripheral blood of 21 patients with systemic lupus erythematosus (SLE) and 45 healthy individuals (HI)...

Ngày tải lên: 12/08/2014, 15:23