gastrointestinal disease in systemic lupus erythematosus
Báo cáo y học: " The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus" doc
... model of lupus- prone mice fed high-fat chow or administered leptin had accelerated and increased proteinuria, suggesting an interplay between diet and lupus [68] Certainly, some murine lupus models ... Raggi P, Stein CM: Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis Lupus 2009, 18:799-806 53 Clancy R, Ginzler E: Endothelial ... activates plaqueresiding CD4+ T cells to increase TNF-related apoptosisinducing ligand (TRAIL) expression, which results in killing of plaque stabilizing cells and a potential increase in the risk of...
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Báo cáo y học: " Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study" pdf
... deviation; SLE: systemic lupus erythematosus; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; SLICC/ACR DI: Systemic Lupus Erythematosus International Collaborating Clinics / American ... describing changes in disease activity in Systemic Lupus Erythematosus J Rheumatol 2000, 27:377-379 13 Ibanez D, Gladman DD, Urowitz MB: Adjusted mean Systemic Lupus Erythematosus Disease Activity Index-2K ... remained CAD-free Covariates Covariates included in the proportional hazards models were sex, age, disease duration, disease activity score (Systemic Lupus Erythematosus Disease Activity Index...
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Báo cáo y học: "Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus" potx
... the inflammatory cytokine interleukin-6 Biochem Pharmacol 2000, 60:1185-1195 33 Cross JT, Benton HP: The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus ... 1997, 24:303-308 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin-15 is elevated in systemic lupus erythematosus Rheumatology ... DC-poietins in systemic lupus erythematosus Hum Immunol 2002, 63:1172-1180 47 Scheinecker C, Zwolfer B, Koller M, Manner G, Smolen JS: Alterations of dendritic cells in systemic lupus erythematosus: ...
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Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx
... protein autoantibody; CRP, C-reactive protein; mSLEDAI, modified systemic lupus erythematosus disease activity index; n.s., not significant; SLEDAI, systemic lupus erythematosus disease activity index ... during infection, systemic inflammation or tissue damage [4] The family includes long pentraxins, such as pentraxin produced by mononuclear cells in response to lipopolysaccharide, interleukin-1β ... Zoma A: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus Arthritis Rheum...
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Báo cáo y học: "B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels" ppsx
... 20:829-833 Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus Clin Exp Immunol 1979, 35:76-88 Klinman DM, ... and in writing the final version of the manuscript DMH assisted in the design in the study, in the interpretation of the results, and in writing the final version of the manuscript DN assisted in ... saturated in vivo with circulating BLyS, rendering them incapable of binding to BLyS in the in vitro detection assay We not yet know whether the antiBLyS autoantibodies are functionally neutralizing...
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Báo cáo y học: "Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients" docx
... chemokine score was dramatically increased LN, lupus nephritis; SDI, Systemic Lupus International Collaborating Clinics/American Society of Rheumatology Damage Index; SLE, systemic lupus erythematosus ... chemokine ligand; CXCL, C-X-C chemokine ligand; IFIG, IFN-inducible gene; IFIT, interferon-induced protein with tetratricopeptide repeats; IL, interleukin; IP-10, interferon-inducible protein 10; ... donation using the SLE Disease Activity Index 2000 (SLEDAI-2K) [16] and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) [17] Sample handling...
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Báo cáo y học: "TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus." ppsx
... vitamin K-dependent protein that has 46 to 48% amino acid identity to protein S, was discovered in the early 1990 s [15] It contains an N-terminal g-carboxyglutamic acid (Gla) domain, interacting ... of systemic lupus erythematosus; APS, antiphospholipid syndrome; BILAG, British Isles Lupus Assessment Group; F, female; M, male; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index intra-assay ... to beta(2)-glycoprotein I, prothrombin, protein C, protein S, and annexin V in patients with systemic lupus erythematosus and thrombotic and thrombocytopenic complications Clin Chem 2001, 47:1008-1015...
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Báo cáo y học: "Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis" pot
... the inflammatory process in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) even though both Gas6 and sAxl in most of the patients were within the normal range [13] Systemic lupus ... that sMer is increased in active SLE and to a lesser extent in RA In contrast, neither sMer nor Tyro3 plasma concentrations are increased in CLI suggesting that the increased sMer in SLE is not ... J, Pascual V: Type I interferon in systemic lupus erythematosus and other autoimmune diseases Immunity 2006, 25:383-392 37 Pascual V, Farkas L, Banchereau J: Systemic lupus erythematosus: all roads...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... systemic lupus erythematosus Int Arch Allergy Immunol 2000, 123:36-45 27 de Wildt RMT, Tomlinson IM, van Venrooij WJ, Winter Ga, Hoet RMA: Comparable heavy and light chain pairings in normal and systemic ... complexes containing alkaline phosphatase/anti-alkaline phosphatase were detected by incubation with new fuschin substrate, and the sections were counter-stained with Mayer’s haematoxylin (Sigma)...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30...
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Báo cáo y học: "Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies" pdf
... The Mexican Systemic Lupus Erythematosus Disease Activity Index and the Systemic Lupus International Collaborating Clinics/American Collage of Rheumatology Damage Indexes at the beginning of the ... Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics aInformation for treatment was available in 19 patients in this group bAzathioprine, methotrexate, ... active viral infection in 20 systemic lupus erythematosus patients Lupus 2000, 9:120-126 Su BY, Su CY, Yu SF, Chen CJ: Incidental discovery of high systemic lupus erythematosus disease activity...
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Báo cáo y học: "Cytokines in systemic lupus erythematosus, London, UK" ppt
... ameliorate disease in murine models of SLE In a small clinical trial, 21 daily doses of intravenous monoclonal murine anti-IL-10 antibody led to a clinical improvement in patients with SLE This was maintained ... antibodies in systemic lupus erythematosus J Rheumatol 1991, 18:230234 Lawman S, Ehrenstein MR: Many paths lead to lupus Lupus 2002, 11:801-806 Ehrenstein MR, Cook HT, Neuberger MS: Deficiency in serum ... Isenberg DA: The effect of interleukin-10 and interleukin-12 on the in- vitro production of antidouble-stranded DNA antibodies from patients with systemic lupus erythematosus Clin Exp Immunol 2001,...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 1962, ... cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus Curr ... factors of carotid plaque in women with systemic lupus erythematosus Arthritis Rheum 1999, 42:51-60 Salmon JE, Roman MJ: Accelerated atherosclerosis in systemic lupus erythematosus: implications...
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Báo cáo y học: "Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies" docx
... OD All Available online http://arthritis-research.com/content/6/4/R366 Table Demographic and clinical findings in patients with systemic lupus erythematosus grouped according to their psychiatric ... protein antibodies with CNS disease, excluding lupus psychosis [51] Interestingly, the ribosomal P protein P0 has been identified by molecular cloning strategy as an endothelial autoantigen in ... Richardson EP: The neurological manifestations of systemic lupus erythematosus Medicine 1968, 47:337-369 Wekking EM: Psychiatric symptoms in systemic lupus erythematosus: an update Psychosom Med 1993,...
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Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt
... [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer After washing three times with PBS, cells were incubated for hour ... then incubated for 30 at 25°C in the blocking buffer (2% bovine serum albumin in PBS, containing 5% glycerol and 0.2% Tween-20) Apoptosis was evaluated by propidium iodide staining, according ... staining was observed in cells treated with TNF-α plus cycloheximide (ii) These findings were confirmed in permeabilized cells Indeed, untreated control cells showed anti-Nedd5 staining confined...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... et al.: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum 1997, ... Clinical Research Facility Patients underwent a full clinical assessment, including measurement of disease activity using the SLE Disease Activity Index (SLEDAI) [12] Therapy was recorded, including ... transforming growth factor-beta Lupus 1999, 8:95-102 Bruce IN, Gladman DD, Urowitz MB: Premature atherosclerosis in systemic lupus erythematosus Rheum Dis Clin North Am 2000, 26:257-278 Grainger...
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Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf
... not be acceptable for use in SLE Another curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the overall clinical response rate above ... is only limited preclinical information available on the signaling mediated by epratuzumab binding to CD22 on various subsets of B cells [9] Several monoclonal antibodies against mouse CD22 have ... experience Competing interests RE has received support from Genentech for investigator and industry sponsored clinical trials, basic laboratory work and consultations regarding the development...
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Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases" pps
... with the recombinant RPA32 protein Antibodies against RPA32 were found in 10.9% (87 of 801) in breast cancer patients and in 10.3% (4 of 39) in intraductal in situ carcinoma patients, in contrast ... replication proteinA in some patients with systemic lupus erythematosus (SLE) Clin Exp Immunol 1996, 103:74-76 McNeilage LJ, Umapathysivam K, Macmillan E, Guidolin A, Whittingham S, Gordon T: Definition ... production in pristane-induced lupus J Immunol 2000, 165:1036-1043 Rubin RL: Enzyme-linked immunosorbent assay for anti-DNA and antihistone antibodies including anti-(H2A-H2B) In Manual of Clinical...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" ppsx
... lesions in the vicinity of sunburn cells (SBCs) in patients with systemic lupus erythematosus (SLE) Haepatients with systemic lupus erythematosus (SLE) matoxylin eosin (H&E)-stained paraffin sections ... staining), 10 mM citrate pH 6.0 (CD68 staining), or 10 mM Tris, mM EDTA pH 9.0 (CD3 staining) After washing in PBS, endogenous peroxidase was blocked by incubation in 0.37% H202 in PBS for 30 minutes ... specifically induces inflammation in LE lesions Binding of autoantibodies to apoptotic keratinocytes in the skin and subsequent pro-inflammatory clearance by macrophages could be involved in induction...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" pot
... effectively induced apoptosis in FLS even in the presence of a dominant-negative p53 Discussion Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal ... accumulation of cells in the lining can be due to ingress of cells from the blood, local proliferation, or insufficient deletion through apoptosis The latter is especially intriguing in view of the ... are either defective or minimally expressed in RA, including p53, sentrin [19], and PTEN (phosphatase and tensin homologue deleted on chromosome 10 [20] p53 is an interesting potential therapeutic...
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