ADVANCES IN PROTEIN KINASES ppt

ADVANCESIN PROTEINKINASES  EditedbyGabrielaDaSilvaXavier            Advances in Protein Kinases Edited by Gabriela Da Silva Xavier Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Romina Skomersic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published June, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Advances in Protein Kinases, Edited by Gabriela Da Silva Xavier p. cm. ISBN 978-953-51-0633-3    Contents  Preface IX Chapter 1 Cross-Regulation of JAK-STAT Signaling: Implications for Approaches to Combat Chronic Inflammatory Diseases and Cancers 1 Claire Rutherford, Hayley D. Woolson and Timothy M. Palmer Chapter 2 Interactions of the Protein Kinase A Signaling Pathway: Implications for the Treatment of Endocrine and Other Tumors 41 Audrey J. Robinson-White Chapter 3 The Role of Tpl2 Protein Kinase in Carcinogenesis and Inflammation 81 Katie DeCicco-Skinner, Monika Deshpande and Jonathan Wiest Chapter 4 MEK1/2 Inhibitors to Treat Dilated Cardiomyopathy Caused by LMNA Mutations 97 Antoine Muchir Chapter 5 Signaling Pathways Coupled to Activation of the Kinin B1 Receptor 109 Pamela Ehrenfeld, Carlos D. Figueroa, Kanti D. Bhoola and Carola E. Matus Chapter 6 Multiple Kinase Involvement in the Regulation of Vascular Growth 131 Shaquria P. Adderley, Chintamani N. Joshi, Danielle N. Martin, Shayna Mooney and David A. Tulis Chapter 7 The Physiological Relationship of Endothelial Protein Kinase G with Endothelial Nitric Oxide Synthase 151 Theresa A. John and J. Usha Raj Chapter 8 The Role of Tyrosine Kinases in the Pathogenesis and Treatment of Lung Disease 181 Jonathan Lam and Stewart J. Levine VI Contents Chapter 9 Myotonic Dystrophy Protein Kinase: Structure, Function and Its Possible Role in the Pathogenesis of Myotonic Dystrophy Type 1 213 Jonathan J. Magaña, Rocío Suárez-Sánchez, Norberto Leyva-García, Bulmaro Cisneros and Oscar Hernández-Hernández Chapter 10 Protein Kinases in the Pathogenesis of Muscle Wasting 243 Fabio Penna, Domiziana Costamagna, Andrea Camperi, Maurizio Muscaritoli, Francesco M. Baccino and Paola Costelli Chapter 11 Mathematical Modeling of Syk Activation in Allergen-Stimulated Mast Cells and Basophils 271 Ambarish Nag, Michael I. Monine, Byron Goldstein, James R. Faeder and Michael L. Blinov Chapter 12 Roles of Kinases in Osteoblast Function 313 Tetsuya Matsuguchi Chapter 13 The Role of Mitogen-Activated Protein Kinase in Treatment Strategies for Fear and Drug Addiction 333 Robyn Mary Brown, Andrew J. Lawrence and Jee Hyun Kim    Preface  Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborativeeffort,withcontributionfromexpertsintheirrespectivefields,reflecting the spirit of collaboration‐across disciplines and borders‐that exists in modern science.Here, wereview theexistingliteratureand, onoccasions,provide noveldata onthefunctionofproteinkinasesinvarioussystems.Wealsodiscusstheimplications ofthesefindingsinthecontextofdisease,treatment,anddrugdevelopment.  GabrielaDaSilvaXavier ImperialCollegeLondon,SectionofCellBiology, DivisionofDiabetes,EndocrinologyandMetabolism, London, UK