... solid line), in the presence of100 lM neurotoxin (•, dotted line), in the presence of 200 lM neurotoxin ( , dottedline) and in the presence of neurotoxin and50 lM dopamine (h, dashed line).Modulation ... Nota-bly, in the presence of the neurotoxin, there was adelay in the lag time for fibrillation. The lag timeincreased from 74.9 h in case of a -synuclein alone to 86.8 and 93.6 h in the presence ... associated with Parkinson’sdisease in a-synuclein-deleted mice [30]. Continuousinfusion of the neurotoxin MPTP, however, has beenshown to induce symptoms of parkinsonism in amouse model [27]....