Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. CYP3A5 ... although epigenetic factors must be taken into account [7]. The aim of the present study was to determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in renal trans-plant ... Heiden IP, et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin Pharmacol Ther. 2003; 74: 245-54....
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Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"
... words.Symptom 2 S2 Optional and is second symptom which is partof the same problem as symptom 1Activity A An activity of daily living of importance to thepatient in which Symptoms 1 and 2 interferewith. ... deliveredby student chiropractors in a clinical teaching facility .The W-BQ12 was also used as a tool to assess the validityof the well being component of the MyMOP2 against thevalidated W-BQ12 instrument ... problem they need assistance withand consider the severity of these symptoms over thelastweek.Thethirditemasksthepatienttolistanactivity (such as walking) that they have had difficultycompleting...
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Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... hugerisks and acted with great bravery to return to the clinicand to obtain their medication refills.▪ Patients really surprised us. They walked distances, theyran away, they tried again, they came ... weredone to increase the credibility of the results. Investigatortriangulation was used by involving additional investiga-tors in reviewing the recordings and field notes and inconfirming or disconfirming ... unpredictableand very unsafe. And so families felt trapped...Because itwas life-threatening for them to go on the roads and try toget [to clinic] .The risks to personal safety were seen to vary based on the...
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Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"
... idiopathic cyclic edema was based on a clinical history and fluid retention throughout the day, in particular difficulty in removing rings on waking in the morning which improves later in the ... on waking in the morning which im-proves later in the day. Some patients reported facial edema early in the morning and swelling of the legs at the end of the day. Participants were asked to weigh ... can be divided into three main grades based on the clinical severity. Grade I is characterized by smooth skin without any dimpling upon standing and laying down, but the skin adopts a mattress-like...
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Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"
... which in turn reacts with a mixture of the dansyl derivative and the N-ethyl-diisoproylamine and the dansyl sulfamidoethylamine to the tetrazine product 7 linked with 5-dansyl sulfamidoethylcarboxamide-2-yl. ... 2-cyano-nicotinic acid 4 with hydrazine to 5. After oxidation the dihydrotetrazine product bis-2,6-[5-carboxylic acid-pyrid-2-yl]-dihydrotetrazine 5 was transformed to the cor-responding tetrazine 6, ... as candidates for cell- and tissue specific therapeutic approaches. They are also ideal as diagnostic tools in the increas-ing fields of the patient-specific therapy and in imag-ing of...
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Báo cáo y học: " Efficacy of the Valsalva Maneuver on Needle Projection Pain and Hemodynamic Responses During Spinal Puncture"
... 4-point scale and VAS, in which the first scaling was used during the canula-tion and VAS was used after the canulation. They found a significant reduction in the incidence of pain in the ... have been used to obtund pain of needle insertion including infiltration analgesia and EMLA patch. Local anesthetics themselves may pro-duce pain on injection and many anesthetists are un-sure ... within the chest and in turn results in baroreceptor activation. Activation of either the car-diopulmonary baroreceptor reflex arc or the sinoaor-tic baroreceptor reflex arc induces...
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Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"
... by Atherton and Sheppard.[40] Synthesis of the Fmoc-C2-glycine-tert-butyl ester The synthesis of the peptide nucleic acid back-bone requires the introduction of protecting groups as shown in the ... essential. The generally accepted syntheses of the de-sired PNA building blocks are shown in the following schemata and are documented in detail by the Thomson group.[38] The synthesis begins with the ... continuously over night and concentrated by the rotary evaporator. The yellow residue 15 featured oily consistency and was dissolved in dichloromethane. The solvent was removed by the rotary evaporator...
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Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’s Cytotoxicity in Culture"
... of B19 NS1-induced cytotoxicity of liver cells. Our results support the hypothesis that in the setting of persistent B19 infection, direct B19 NS1-induced cytotoxicity may play a role in idiopathic ... imme-diately analyzed by flow cytometry. For AnnexinV binding analysis 5 x 105 cells were washed once with PBS and resuspended in 500 µL AnnexinV Binding Buffer and 5 µL AnnexinV-PE (AMS Biotechnology ... LTD., Abington, OX, UK), incubated for 15 min at room temperature in the dark and immediately ana-lyzed by flow cytometry. The percentage of cells ex-pressing the EGFP marker, as well as the distribution...
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Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"
... of PPARα, γ and δ haplotypes on plasma levels of lipids and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenet. ... supervised by handing out a nutritional diary which was submitted at each of the further visits to the clinic. After 6 weeks the patients attended the clinic again and it is the lipid values and biometric ... detected by silver staining on polyacrylamid gel. Statistical Analysis Allele frequencies were determined by gene counting and compared using the א² test. The data was analysed using SPSS 12.0...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... repairment. To conclude, the above findings not only provide a fundamental insight into the mechanism of CY-induced systemic cytotoxicity, particularly in the gastrointestinal system, but also ... Furthermore, c-Myc is known to induce the transcriptional activity of ODC gene [29], which is involved in polyamine synthesis. It is likely that the cell cycle-arresting action of CY in the stomach ... would extend the therapeutic application of CY in cancer patients in which the herb could be used together with the cytotoxic agent in cancer therapeutic regimen. In the present study, we investigated...
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