calcium intake influences the bone response to exercise in growing children
Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt
... distinct from, apoptosis [9,10] Beclin 1, a class III phosphatidylinositol 3-kinaseinteracting protein [11], plays a role in promoting autophagy [12] Beclin contains a Bcl-2-binding domain which may ... serve as a point of cross-talk between the autophagic and apoptotic pathways Recently, a BH3 domain in the Bcl-2-binding domain of Beclin was shown to bind to Bcl-XL [13] Anti-apoptotic Bcl-2 ... MagicRed-Cathepsin B substrate was added to the cells during the last 30 of an experiment according to the manufacturer’s instructions Calcium imaging For dye loading, Fluo-4 was dissolved in in 20%...
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Báo cáo y học: " Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma" pdf
... reproducibility of the airway response to exercise in the type of individual most likely to be referred for exercise testing for EIB Exercise testing to identify EIB in the laboratory is affected by the type ... variation in the exercise response is critically important when interpreting a negative test or when evaluating an exercise response to a therapeutic agent The ventilation reached and sustained during ... tests The reproducibility of the exercise response in relation to the different NAEPPII scores is given in Table There was no relationship between the NAEPII score and the severity of the response...
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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... carried out attempting to clarify the influence of various factors on tacrolimus kinetics However, the results remain controversial with regard to pharmacokinetic and clinical effect of the studied ... hospital and informed consent was obtained from all subjects Maintenance treatment scheme consisted of a combination of a calcineurin inhibitor (tacrolimus) with a purine inhibitor (mycophenolate ... immunosuppressive therapy although epigenetic factors must be taken into account [7] The aim of the present study was to 95 determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of...
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The Consumer Response to Food Labeling
... named products The future of the EU policy is then discussed, in relation to the changes in the international framework Indeed, the status of the EU labeling system relative to the international ... consumers in order to have a potential impact Together with the introduction of the mandatory beef labeling regulation in Europe, consumer information campaigns were initiated Questions pertain to the ... to document the history of their animals two years from now, including those being born right now, will find themselves unable to sell to supermarkets forcing their beef into the export or foodservice...
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báo cáo hóa học:" Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist" potx
... important to demonstrate the ability of the CCR2 antagonist to inhibit the saturating concentration of the AF488-MCP-1 used in the assay To accomplish this CCR2 antagonist was titrated into the assay ... of the assay to demonstrate inhibition of ligand internalization at low concentrations of CCR2 inhibitor, was determined by serially diluting the CCR2 antagonist into whole blood and incubating ... were identified and examined for their ability to bind to receptor positive cells Identified peaks were pooled and retested for binding in a flow cytometry binding assay The reagent was aliquoted,...
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báo cáo hóa học:" An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod model" doc
... therefore designed a study to investigate the factors contributing to osseointegration in orthopedically relevant surfaces The study hypothesis was that the addition of a hydroxyapatite coating ... powders were injected with Argon as the carrier gas to produce coating with thickness ranging from 40-70 microns (nominal 50 microns) The coating had a minimum total crystallinity of 65% The minimum ... was used to detect pixels at the perimeter of the implant and the bone and soft-tissue pixels adjacent to the edge of the implants were counted Osseointegration was defined as bone- to- implant...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... through G1 into S phase requires cyclin D-CDK4/6 and cyclin E-CDK2, which phosphorylate the retinoblastoma protein [26] CDK inhibitors (CKIs) are the negative regulators and are grouped into two ... TGF1 [29-32] The aim of the present study was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposus cells The study was designed to (1) analyze the effect of ... cells in the S phase differ among individuals, these inhibitors both seem to block the mitogenic effect of TGF1 completely The statistical significance by the repeated measures ANOVA of the cell...
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Báo cáo y học: "Mactinin: a modulator of the monocyte response to inflammation" pps
... ng/ml) The lack of mactinin in rheumatoid arthritis fluid was surprising, and we decided to pursue this further Owing to the autoimmune nature of rheumatoid arthritis, we examined whether mactinin ... released during leukocyte influx into inflammatory tissue Further, mactinin might have a role in promoting the response of mononuclear phagocytes to inflammation The monocyte functional studies in vitro ... as rheumatoid arthritis contain antibodies against microfilament-associated proteins, including α-actinin In addition, auto-antibodies against actin, vinculin, integrins, or fibronectin could...
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Báo cáo khoa học: " The effects of ectomycorrhizal status on carbon dioxide assimilation capacity, water-use efficiency and response to transplanting in seedlings of Pseudotsuga menziesii (Mirb) Franco" docx
... the intersection of two functions: i), the photosynthetic CO demand function (D) which defines the mesophyll photosynthetic capacity and, ii), the photosynthetic CO supply function (Su) defining ... the WUE values were identical for the two experiments Figure gives an insight into the WUE regulation at the individual level prior to transplanting The regression lines were forced through the ... order to buffer the Pi in the cytoplasm and ii), that an overall minimum cytoplasmic Pi concentration of between 5-10 mmol· is required to sus-1 l tain optimal rates of photosynthesis in the light...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... (IFN)-γ staining but no interleukin (IL)-4 staining Multiplex cytokine assay was used to analyse the cytokine profile of three T-cell line supernatants (b) An excess of Th1 over Th2 cytokines was ... respectively Indeed, intracellular IFN-γ staining, but not IL-4 staining, was detected in our T-cell lines, confirming the Bio-Plex data (Figure 3a) Discussion In this report, we demonstrate that in a ... assayed for cytokine content using a Bio-Plex assay We detected abundant Th1 cytokines, including IL-2, IFN-γ, and TNF-α Th2 cytokines, including IL-4, IL-6, and IL-10, were present in much lower...
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Báo cáo y học: "olutionary divergence in the fungal response to fluconazole revealed by soft clustering" pptx
... Algorithm) The term ‘soft clustering’ has also previously been used in other clustering methods to define cases in which a gene can belong to more than one cluster rather than any constraint used to ... discussed in the main text and in Additional file 1, the appropriate value of the reward, W, can be determined using complementary information Here, it was tuned to maximize the GO enrichment of the ... Neither of these responses have evolved in Kl, leading to its severe drug sensitivity These conclusions are supported by follow-up experiments demonstrating that growth in ergosterol increases the...
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báo cáo khoa học: " Public health the leading force of the Indonesian response to the HIV/AIDS crisis among people who inject drugs" doc
... influence in specific aspects of the response in Indonesia In addition to the efforts from the Indonesian national government and international partners, there are local responses organized in ... reduction, including the commitment of their provinces' budgets to support the scaling up of the response Some political resistance has arisen from some sectors of the police that prefer to maintain ... IDUs in several provinces including Bali, West Java and other regions indicate a high rate of injecting Buprenorphine as heroin becomes scarcer in the market Methadone was established first in Indonesia...
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Báo cáo khoa học: "PreS1 epitope recognition in newborns after vaccination with the third-generation Sci-B-Vac™ vaccine and their relation to the antibody response to hepatitis B surface antigen" potx
... whereas the N-terminal part is believed to play a major role in mediating virus attachment and entry into hepatocytes [3] Within the preS1 protein, the 21–47 amino acid epitope was shown to mediate ... enhanced response to HBsAg We found that recognition of several preS1 epitopes, and in particular, the epitope contained within the second half of the hepatocyte binding site localised in the hepatitis ... shown to represent human B cell epitopes within the hepatocyte binding site comprising amino acids preS1 (21–47) [[4,6,7], reviewed in [23]], as well as the C-terminal part comprising amino acids...
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Báo cáo y học: " Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using modelbased approaches" ppt
... 6), the similar outcomes from the two analyses reinforce the overall conclusions while providing further insights into the impact of patient characteristics on dose response The key finding of the ... included in this analysis The most striking feature of the plot is that the response to indacaterol at the plateau exceeds the response of all comparators In other words, doses of indacaterol 150 μg ... characterization of the doseresponse relationship of indacaterol and the responses to comparators used in some trials The key metrics of interest were: the minimum effective dose (MED), defined as the lowest...
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Báo cáo y học: " Private specificities can dominate the humoral response to self-antigens in patients with cryptogenic fibrosing alveolitis " pps
... epitopes in the protein [14] Interestingly, the authors of that study noted a correlation between the type of epitope and the disease duration, supporting the hypothesis that the autoantibody response ... of the parent cDNA The others encoded truncated proteins, missing the amino-terminal 38, 54 or 447 residues of the parent 968-residue polypeptide, indicating that at least part of the immune response ... these sera Convincingly, the index case retained a strong reaction to each of these antigens in sera obtained consecutively over the following 18 months Discussion It is evident that the humoral...
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Báo cáo y học: " Beyond the first 25 years: The International AIDS Society and its role in the global response to AIDS" pps
... activists and others working on the frontlines of the response The IAS encourages all professionals working in the HIV/AIDS field to become members We are convinced that in the struggle against this ... society, and the IAS is looking at ways to strategically expand its role in this area in order to strengthen the capacity of the HIV workforce The IAS has been increasingly involved in policy and ... diversity, to facilitate cross-disciplinary linkages and dialogue, and to strengthen the focus on youth – began to be implemented in the planning for the XVI International AIDS Conference (AIDS 2006) in...
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Báo cáo y học: "The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study" pot
... Plasma insulin Plasma insulin and insulin:glucose ratio is shown in Figures 2a and 2b There was no difference in plasma insulin concentration at baseline Plasma insulin increased in response to intraduodenal ... patients has hitherto not been evaluated The primary aim of this study was to determine whether exogenous GLP-1 attenuates the glycaemic response to small intestinal nutrient infusion in critically ... [18] Given the above considerations it was appropriate to initially determine whether GLP-1 attenuates the glycaemic response to small intestinal, rather than intra-gastric, nutrient Whether GLP-1...
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Báo cáo y học: "Exogenous glucagon-like peptide-1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients with type-2 diabetes" ppsx
... determine response to GLP-1 [23] We were unable to determine which factors predicted glucose-lowering in this small sample The mechanism(s) underlying the glucose-lowering that occurs with GLP-1 in ... shown to have the capacity to attenuate the postprandial increase in NEFA in other groups [28,31] In this study GLP-1 had no apparent effect on lipidaemia, but, the small intestinal nutrient infusion ... end there was an increase in serum insulin during GLP-1 when compared to placebo (at t = 270 minutes: GLP-1: 23.4 ± 6.7 vs placebo: 16.4 ± 5.5 mU/l; P < 0.05) There was no difference in the insulin...
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Báo cáo y học: "The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis" ppsx
... of expression and red indicating the highest level, as depicted on the bottom The numbers at the top indicate hours relative to pupariation, with green bars representing the peaks of 20E titer ... The first number in each cell represents the number of overlapping genes between the two datasets being compared The numbers within the parentheses in each cell represent a p value based on the ... role in controlling metabolic responses at pupariation, directing the change from a feeding growing larva to an immobile non-feeding pupa Genes that change their expression upon microbial infection...
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- a history of the american response to need
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- evaluation of the immune response to pneumococcal capsular polysaccharides
- control of the host response to histoplasma capsulatum
- the response of the medical profession to acupuncture in great britain
- research into the response of the medical profession to acupuncture in britain
- the impact of type 1 diabetes on the physiological responses to exercise
- an atypical receptor mechanism mediates the bronchoconstrictor response to
- wnt signaling and the bone response to mechanical loading
- λ1 enhanced the chemokines response to lps in pbmc
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