Báo cáo y học: "The intelligence in developing systems for molecular biology" potx

... 301.3Genome Biology 2007, 8:301Genome Biology 2007, 8:301Meeting reportThe intelligence in developing systems for molecular biologyS Cenk SahinalpAddress: School of Computing Science, Simon ... sources for visualizing,inferring the topologies of, or understanding the dynamicsof networks and subnetworks. Using genotype information,gene expression, protein-protein interaction, protein phos-phorylation ... efficiently classify theremaining genes in the dataset.RNA bioinformatics and structural informaticsThe importance of ncRNAs was recognized in 2006 by theaward of the Nobel prize for Physiology or...

Báo cáo y học: " The elderly in the psychiatric emergency service (PES); a descriptive study" pot

... completed forms were forwardedto the principal investigator on a weekly basis for dataentry.Many strategies were used in order to minimize diag-nostic uncertainty in both data collection efforts. ... datasets were of t henominal type (binary or with multiple categories). Preli-minary analyses consisted of constructing contingencytables where the binary independent grouping variable(≥ 65, < ... Surles RC, McGurrin MC: Increased use of psychiatric emergency servicesby young chronic mentally ill patients. Hosp Community Psychiatry 1987,38:401-405.Chaput et al. BMC Psychiatry 2011, 11:111http://www.biomedcentral.com/1471-244X/11/111Page...

Báo cáo y học: " The macrophage in HIV-1 infection: From activation to deactivation?" potx

... even in the absence of proinflammatorycytokines, especially in macrophages [9,148,150]. Theseviral proteins play a role in the formation of viral reser-voirs in macrophages by activating transcription ... production of cyto-kines [212], viral replication remains very low duringthe asymptomatic stage of HIV-1 infection. Specificimmune responses including Th2 cytokines an d CTLscontinuously inhibit ... and HIV-1InfectionClassically activated or type 1 macrophages induced in particular by IFN-g [10], display a pro-inflamm atoryprofile (Figure 1). In addition pro-inflammatory cyto-kines modulate...

Báo cáo y học: "The next frontier of systems biology: higher-order and interspecies interactions" pps

... strategy for studying biological systems than as a ﬁeld of biology. Systems approaches have been very successful in the realms of biochemistry and genetics, especially for genetically tractable ... super-linearly. Put simply, screening 100 times as many genes yields more than 100 times the information; the additional information consists in learning how groups of genes behave, enabling ... sensing and other intraspecies signaling in prokaryotic cells.Changes over space and timeMost systems- biological experiments study genetic and biochemical interactions at a single time point....

Báo cáo y học: "The missing graphical user interface for genomics" pdf

... analysis is done, the Galaxy record will eliminate any ambiguity as to which result used which settings. In the long term, the Galaxy history is invaluable if an unforeseen follow-up analysis ... ﬁle formats are com-patible and makes analysis accessible, but until systems for analyzing semantic dependencies of this kind are available, Galaxy cannot make analysis fully automatic and intelligent. ... clear if any package I use today will work in 20 years. Galaxy mitigates this problem by using open standards and building a community of users and developers beyond a single funding source,...

Báo cáo y học: "Mutation discovery in mice by whole exome sequencing" potx

... sensitivity of cur-rent analytical pipelines for detecting single nucleotidesubstitutions (and particularly homozygous substitu-tions), combined wit h the propensity of damaging singlenucleotide ... exomesequencing provides sufficient coverage of flanking intronsequence to positively identify potentially damaging, non-coding mutations in the intron sequences immediatelyflanking target ... Trembath R, Jeffery S: Rapididentification of mutations in GJC2 in primary lymphoedema usingwhole exome sequencing combined with linkage analysis withdelineation of the phenotype. J Med Genet...

Báo cáo y học: " Involving relatives in relapse prevention for bipolar disorder: a multi-perspective qualitative study of value and barriers" pptx

... each interview was separately analyzed by at least one other researcher to check for reliability of coding. Findings and themes were discussed regularly by an interdisciplinary team comprising ... complexity of managing bipolar disorder for each party. In order to fully realize the benefits of involving relatives in relapse prevention, additional training and support for community care coordinators ... coded into a word document which was refined and elaborated in light of incoming data and analysis employing an inductive stance. The interviewer conducted the analysis on all interviews. In addition,...

Báo cáo y học: " The customization of APACHE II for patients receiving orthotopic liver transplants" pptx

... probability models for early severesepsis in adult intensive care patients. JAMA 1995, 273:644-650.8. Apolone G, D’Amico R, Bertolini G,, Iapichino G, Cattaneo A, DeSalvo G, Melotti R: The performance ... customizationstrategies in the performance of a general severity score. CritCare Med 1997, 25:2001-2008.11. Metnitz PG, Valentin A, Vesely H, Alberti C, Lang T, Lenz K,Steltzer H, Hiesmayr M: Prognostic performance ... model is promising, but it should be empiricallytested in a larger database, constructed to reflect the case mixof liver transplantation patients. For the moment, therefore, it remains to be shown...

Báo cáo y học: " The PIRO concept: P is for predisposition" ppsx

... they are in real trouble, andas I mentioned before that covers any phenotypicmanifestation that may be underlying the geneticpredisposition. So I think that is clearly going to be important in ... in risk stratification. Genetic association studiesusing single nucleotide polymorphisms or insertion–deletionvariants are increasingly in the scientific literature. AMEDLINE search I performed ... The PIROconcept should be helpful not only for clinical routine, but for experimental hypothesis testing. We were interested in infectious diseases in relation to atherosclerosis, and wehave...

Báo cáo y học: "The PIRO concept: I is for infection" pot

... they may haveunderlying diseases but they are dying of infection. Whenyou talk about nosocomial pneumonia, and they have theirfifth episode of nosocomial pneumonia, they have had twoline infections ... quantify it in anyway?[JC] Yes, one of the things that Tony mentioned in passing isthat one simple way in which you could do this, which isanalogous to the tumors/nodes/metastases thing, is ... thing, is to sayclearly it makes a difference as to whether you think thisorganism is simply colonizing or whether it is causing a realinfection. So you could imagine you might say ‘I0’ iscolonization,...

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