... have as yet described all the man-ifestations necessary to be considered a spontaneous modelof relapsing polychondritis – which is characterized not only bypolyarthritis, but also by involvement ... phenotype, more closely mirroring human RP thaninduced polychondritis. This model occurs in the absence ofovert stimulation by an exogenous antigen such as CII, or adju-vant, or by artificially ... Kobayashi Y, Nishikori Y, Dekio S, Okunishi H:Increases in mast cells and chymase in fibroproliferative pawsof collagen-induced arthritic mice. Inflamm Res 1999,48:318-324.20. Kobayashi Y, ...