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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx

Báo cáo y học:

Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx

... Søreide: The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley? Scandinavian Journal of Trauma, ... biomarker among the increas-ing number of alternatives investigated [17-19], or merely be yet another blind alley in the surge for the correct diagnosis of acute appendicitis remains to beseen.Received: ... urrent study point out [5], the high mobility group box-1 protein (HMGB1) has beenknown for many years as a nuclear chromosomal p ro-tein. Its role as a pro-inflammatory cytokine in sepsisand...
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Báo cáo y học: "Familial Polycythemia Caused by a Novel Mutation in the Beta Globin Gene: Essential Role of P50 in Evaluation of Familial Polycythemi" potx

... history of polycythemia. She had mild fatigue but no other symptoms. Past medical history was unremarkable. Family history was significant for lifelong history of polycythemia in her mother, maternal ... breast in 2002, treated with simple mastectomy and 2) colonic diverticula and internal hemorrhoids since 2005. Family history was remarkable for presence of lifelong history of polycythemia in ... of Hb for oxygen. The majority of mutations affecting oxygen affinity result in high affinity Hb variants which result in leftward shift of the dissociation curve and relative tissue hypoxia...
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Báo cáo y học: "Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes" pot

... advancing age lead to a novel con-ceptual point of view concerning the understanding of the process of thymic physiology in aging, where the increase in adipocytes an fat-bearing cells may Int. ... the organ. These findings suggest that adipocyte precursors or fat-storing cells may be migrating into and /or differentiating actively within the aging thymic microenvironment. Furthermore, ... 6). In the thymus of 12 months of age, CCL4 expression was observed in thymocytes and in mul-tilocular cells in the septa and inside the thymic pa-renchyma. These data reinforced the hypothesis...
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Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx

Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx

... asoutcomes of such calculations may be spoiled by inaccuratepositioning of the interacting groups. The contact area of the distamycin amidinium end wasinvestigated by evaluating the hydrogen positions ... one crystal the distamycin orientation and binding site is the same as in 12-dista, the orientation of the drug is inverted in the other crystal. Both orientations show interactions betweenthedrugandguanineNH2groups. ... crystal structures describe the interaction of distamycin in the minor groove of the central CAATTGsequence in a 1 : 1 binding mode. The present tight crystalpacking due to the triplet formation...
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Báo cáo y học: "Small ruminant feed systems: perceptions and practices in the transitional zone of Ghan" docx

... ruminant performance study.Key informant interviewsKey informants were selected first, using snowball sam-pling, starting with extension agents who guided the selection of other key informan ... non-tethering access groups are signifi-cantly older could explain why less tethering wasreported in matrilineal groups. Old age seems to belinked with no tethering because of the work involved,as ... consisting of leafy feeds obtained mostly at the homestead or in the township, leafy feeds obtained mostlyon farmlands in group 5 and crops and crop by-products in groups 2, 4, and 6. These new groups...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt

... specific mention of acute pancreati-tis, of incidence of pancreatic infection, of related sepsisand mortality, and that the antibiotics used had a minimalinhibitory concentration in the pancreas ... potential risk of the development of bacter-ial resistance.While there is inconclusive data supporting the use of pro-phylactic antibiotics in the setting of severe pancreatitis,there is some ... sepsisand mortality. They included a study by Luiten and colleagues[8], which used selective decontamination of the digestivetract. Selective decontamination is attractive as it may allow the use of...
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Báo cáo y học: "Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers" ppt

... variation in insulin dosing in the casesreporting the use of HIET in CCB overdose and in the duration of treatment, rational recommendations couldcurrently consist of the administration of 1.0 ... hypokalaemiamay offer benefit by promoting cellular calcium entry andincreasing the inotropic effect of insulin [21,24].Recommendations for the use of HIET in CCBpoisoningAlthough there is wide ... consist of intravenousfluids, calcium salts, dopamine, dobutamine, noradrenaline(norepinephrine), phosphodiesterase inhibitors or glucagonoften fail to improve the haemodynamic condition of the patient,...
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Báo cáo y học: " A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction" ppt

... of by-passing the primary receptor and interacting directly with the co-receptor [11-15]. In these "CD4-independent" strains of virus, the chemokine receptor binding site may be moreexposed ... in favour of either reinstating the N-linked glycosylationsites following infection or suppressing the replication of T271I and Y3 42N bearing variants in vivo.Neither the T271 nor the N34 2Y ... of the N-linked glyco-sylation may have enhanced the ability of the Env tointeract with CXCR4, either facilitating partial CD134-independent entry or by enhancing the affinity forCXCR4. To...
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Báo cáo y học: " HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain" doc

... corresponding to the basic domain of Rev inhibited the in vitro splicing of RRE containing mRNAs underscores the functional importance of this region [39,40]. Theseresults therefore support the ... to clarifying why oligomer formation is essentialfor Rev activity by assessing the requirements for restora-tion of the activity of the mutant.Results The intracellular localization of Rev and ... Rex. The function of the HTLV-I Rex protein is similar to that of Rev and the basic domains from the two viral proteinsbind to Importin β during nuclear import [35,36]. It istherefore likely that...
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Báo cáo y học: "Functional constraint and small insertions and deletions in the ENCODE regions of the human genome" ppsx

... inserted/deletedbases and the flanking five bases on either side of the indel toexceed a minimum Phred quality score of 22. If these minimawere not met, then the indel was not reported.For this study, indels ... in regulatory regions may reflect that indels are more likely thanSNPs to moderate the structural function of regulatory ele-ments. Indels may play a more important role than SNPs in contributing ... evolutionary constraint. Hence, the explanation forthis potentially counterintuitive observation is probably that the indel polymorphisms are largely confined to the genedeserts, whereas the constrained...
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