Báo cáo y học: " The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species " doc

... crucially implicated in quartz-induced pulmonary diseases, including fibrosis and cancer. We have investigated the significance of the particle surface reactivity of respirable quartz dust in relation ... evidence showing that mod- ification of the particle surface by either grinding or coat- ing with PVNO or aluminium salts modifies quartz- induced cytotoxicity,...

Ngày tải lên: 12/08/2014, 18:20

... arginine residues in IS4V H As reported previously, the presence of the heavy chain of IS4 plays a dominant role in binding to CL [29]. IS4V H binds CL in combination with six of the 10 light chains tested ... dominant in conferring the ability to bind cardiolipin (CL). In contrast, the identity of the paired variable light chain region (V L ) determined the...

Ngày tải lên: 09/08/2014, 06:22

... and revised the manuscript. VPH was involved in study design and conduct of the clinical studies, in design of the current analyses, contributed to interpreting the results in a clinical context, ... M, Deng C: The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight ga...

Ngày tải lên: 11/08/2014, 16:22

... initially binds to the insulin receptor causing autophosphorylation of the β-subunit of the receptor [8]. The protein kinase domain of the β-subunit then phosphorylates tyrosine residues in in- sulin ... incubation with insulin for 15 min to 16 hours. Phosphorylation of p70 S6 kinase on Thr389 is essential for the activation of the kinase [22]. In the presence o...

Ngày tải lên: 12/08/2014, 18:20

... while the time of saline staying in the lungs should be less than 20 s; (b) recovery of more than 50% of the saline used for the lav- age; (c) absence of obvious blood contamination in the BALF, ... The subsequent events of these cellular/humoral interactions are important to the initiation and propagation of the inflam - matory response leading to pulmonary...

Ngày tải lên: 12/08/2014, 18:20

... the 5'capping machinery subsequently recruited. During processive elongation, there is a switch in CTD phospho- rylation to serine 2 phosphorylation resulting in the loss of the capping machinery and the ... may aid in increased Tax transactivation. In this context, HTLV-I infected cells contain increased levels of cyclin E/cdk2 kinase activity, through sequestration...

Ngày tải lên: 13/08/2014, 13:20

... 16 of 17 Most concerning in recent discussion regarding the useofrFVIIainthesettingofinjuryisapotentialrole for this material in magnifying early traumatic coagulo- pathy. Administration of rFVIIa ... Surgery, Professor of Anesthesiology and Clinical Adjunct Professor of Emergency Medicine at the University of Minnesota. Dr. Dries also holds the John F. Perry, Jr. Chair o...

Ngày tải lên: 13/08/2014, 23:20

... proteome/transcrip- tome analysis of the response of Bacillus subtilis to ppGpp synthesis induced in exponentially growing cells by addition of the leucyl- and isoleucyl-tRNA aminoacylation inhibitor DL-norvaline reported ... alterations in the expression of genes involved in oxidative phosphorylation, amino acid biosynthe- sis and metabolism, the urea cycle, aminoacyl-t...

Ngày tải lên: 14/08/2014, 08:20

... distinct career pathway. Involving such physicians in medical emergency teams will likely facilitate the dual roles of these as a clinical outreach arm of the intensive care unit and in identifying problems ... the study consisted of only a 5-minute debriefing to fill out the standardized MET form on each patient and a weekly 1-hour Commentary The evolving story of medic...

Ngày tải lên: 25/10/2012, 10:06

... to antipsychotics. In this case, fluvoxamine monotherapy was effective in the treatment of psychotic major depres- sion, and the switch to sertraline worsened the psychotic symptoms in the patient. The ... psychopharma- cology from that of other SSRIs [29]. It is therefore possible that activation of the dopaminergic system by the inhibition of dopamine transporter...

Ngày tải lên: 08/08/2014, 23:21