... multifactorial and includesMacrovasculopathy (arterial insufficiency), microvasculo-pathy ( neuropathy and diabetic skin microangiopathy), and an increased propensity for infection [3]. Endothelinmay ... requiredadjustments of his insulin dose and addition of on- demand fast-acting insulin. He was also receiving bicalu-tamide 50 mg/day, candesartan 16 mg/day, furosemide20 mg/day, triflusal 6 00 ... decu-bital lesions remained at Wagner grade II. In parallel,his general condition deteriorated, and vascular surgerywas contraindicated.InvestigationGiven the lack of response, risk of amputation,...