... effects of diac-erein/rhein on the synthesis of major proteases involved in bone remodelling/resorption, namely MMP-13 and cathepsinK. Moreover, we sought to gain new insight into the effects of the ... μg/mL).Effect of diacerein/rhein on intracellular signalling pathwaysTo gain insight into the mechanisms of these drugs on the OAsubchondral bone osteoblasts, we further studied the effect of the therapeutic ... many local abnormal biochemical pathways, includ-ing the increased synthesis of several bone markers, growthfactors, cytokines, proteases, and inflammatory mediators. The levels of alkaline...