regenerative medicine in the central nervous system stem cell based gene therapy
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... expressing CCR1, CCR2 or CCR5 mRNA within and around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings ... EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages, ... in understanding the pathogenesis of MS is the reliable identification of phagocytes capable of degrading myelin Since infiltration of leukocytes including monocyte-derived macrophages into the...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... TUNEL+ cells in the SVZ and DG were doublecortin (DCX)+ neuronal progenitors Other TUNEL+ cells in these two regions included GFAP+ cells (which could be stem cells in the SVZ, or astrocytes in the ... all cells and myelin in this tissue Hematoxylin and eosin staining revealed markedly decreased cellularity in the CC in treated Unlike the consistent observations of microglial activation in the ... was reduced by systemic exposure to 5-FU In the CC, the reduction in apparent division of Olig2+ cells was proportionate to the overall reduction in all BrdU+ cells In the SVZ, there was an enhanced...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... single positive-staining bacteria were found in the neuronal processes Both nNOS and iNOS immunoreactivity were found in a proportion of the neurons in the brainstem and the staining pattern was ... of nNOS and iNOS in the nonneurological control brain Both nNOS and iNOS immunoreactivity was recognized in the brain of control goats No inflammatory cells were found in the brain sections of ... listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression of iNOS and the resultant NO generation were confirmed in brains with...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach Discussion The results ... vibration in the building Although proteins not break into ions, introducing charged particles into the nervous system causes an imbalance in the signal transmission that links to the insect’s locomotion ... as the model system We study the effects and interactions of negatively charged gold nanoparticles (nAuNPs) with the cockroaches CNS in vivo The authors refer to the nervous system as the brain...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... and intestine (Kimura, 2011) It is the main H2S-generating enzyme in the cardiovascular system (Zhao et al., 2001, Bian et al., 2006) CSE was detected in relatively large amounts in the myocardium ... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... baculovirus-mediated gene therapy by increasing the expression of the transgene In addition, with their intrinsic anti-tumor activities, HDAC inhibitors also have the advantage to kill tumor cells more ... transgene(s) Therapeutic genes are the transgenes delivered into target cells, which have functional therapeutic effects to ameliorate the diseases The most ideal human gene therapy is the perfect ... of gene therapy, most efforts are still being made to develop safer and more efficient gene delivery vectors 1.2 Gene delivery vectors in central nervous system (CNS) Chapter Introduction In the...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) [32] Despite having shorter fatty acyl chains (the longest being ... contain the same head groups as mammalian cells (phosphoethanolamine, phosphocholine, phosphoserine and phosphoinositol) Drosophila’s sphingolipids also contain a shorter acyl chain on the sphingoid ... sphingomyelinase (SMase) in specific motor neurons These genes in the fly are the homologs of their mammalian sphingolipid catabolyzing counterparts Ceramidase is an enzyme which catalyzes the...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... with the first ATG in the open reading frame The translation termination codon is indicated by an asterisk The sequence obtained by the first degenerate PCR is singly underlined, whereas the sequences ... represent the coding region and the noncoding regions of the planarian PHM cDNA, respectively; whereas the two flanking broad lines outside indicate the k ZAP II vector The two gray boxes in the planarian ... in the planarian nervous system [40], suggesting that the AsA-related electron transfer system, which supports amidation of the neuropeptide, might predate or coincide with the emergence of the...
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Section III - Drugs Acting on the Central Nervous System docx
... integration of the autonomic nervous system, and they may integrate somatic and vegetative functions, including those of the cardiovascular and gastrointestinal systems Limbic System The "limbic system" ... Degenerative Disorders) Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as the central nucleus of the ... cells of this class may be attracted to the brain during periods of inflammation following either microbial infection or other postinjury inflammatory reactions The response of the brain to inflammation...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... however, chemotherapy in increasing doses has become routine Very high dose chemotherapy, requiring bone marrow transplantation or peripheral stem cell support, is now standard therapy for children ... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... infants with malignant brain tumors use even higher doses of chemotherapy, necessitating either bone marrow transplantation or peripheral stem cell support to boost the immune system, and either...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... determine whether these findings resulted in functional impairment, they investigated the auditory brainstem response in the mice at various times following treatment Loss of myelin is known to increase ... increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse conduction between the ear and the brain Exposure to 5-FU caused a progressive increase ... progenitor cells and nondividing oligodendrocytes than to many cancer cell lines in vitro They also found that the agents caused increased cell death and decreased cell division in the subventricular...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... responding to steroids alone [9] But Barron et al [24] indicated that steroid therapy alone failed to improve the condition This finding is consistent with ours Others recommended combination therapy ... Ballardie FW: Primary angiitis of the central nervous system: emerging variants Q J Med 2005, 98:643-654 Markus K, Peter B: Primary central nervous system vasculitis: clinical experiences with 21 new ... Beijing Neurosurgical Institute, Beijing 100050, China Authors’ contributions GY wrote the initial draft WY drew the pictures WZ revised the draft SL described the MRI features GL provided the...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems Large ... analysed using the integrated software of the instrument 27 2.2.7 Cell Lines and Cell Culture Sf9 insect cells were obtained from Invitrogen and cultured according to the manual’s instructions ... components Hence, gene therapy emerges as a promising approach to provide efficient treatment for these difficult diseases 1.1.1 Gene Therapy The main concept of gene therapy is to use genetic materials...
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A study of the recombination activating gene 1 in the zebrafish nervous system
... According to these functions, the nervous system is categorized as sensory system, integrating system and motor system respectively (Delcomyn, 1998) The structural organization of the nervous system ... Rag1 in the nervous system is conserved among vertebrate species and suggest a function 1.2.2 A brief overview of the nervous system The nervous system is the most complex organ system in animals, ... regulation of Rag genes 1.2 Rags in the nervous system 1.2.1 The expression of Rag genes in the nervous system Rag genes were initially identified as lymphoid-specific factors Indeed, Rag genes are strongly...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... functional cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy ... recurrent brain tumors, or to inject drugs with short half-life Gene therapy, on the other hand, can minimize this kind of damage Chapter Introduction to the brain by a single delivery of genetic ... of the cell types in the CNS greatly increase the difficulty of gene delivery In sight of these considerations, special attention has to be paid to the gene delivery system, especially to the...
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Specificity and diversity in the vertebrate nervous system an analysis of two genes
... reached their target neurons in the tectum The Recombination activating gene- 1 (RAG1) is expressed in the vertebrate immune system and in the nervous system, including the zebrafish visual system ... guidance at the midline, Eph-Ephrins are also involved in creating patterned neuronal connections in the CNS and the peripheral nervous system Similar to the topographic mapping in the visual system, ... immediately answer the question of whether RAG1 could generate diversity in neurons as it does in the immune system Nevertheless this finding indicates that RAG1 has distinct binding activity in neurons...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... 26 injected intraperitoneally into the mice followed by injecting 100 μl of 0.4% trypan blue dye into the tail vein of mice In control mice, saline was injected intraperitoneally before injecting ... N-terminаl ѕequencing by Edmаn degrаdаtion The N-terminаl ѕequence of the recombinаnt ohаnin wаѕ АЅPPG, which correѕpondѕ to the N-terminаl of the nаtive protein except for the аlаnine thаt wаѕ in erted ... effects could prove to be the basis in not only understanding the receptor(s) involved in locomotion and pain sensations within the brain, but also into lead to the developing of future pharmacological...
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The central nervous system
... 9/20 The Central Nervous System Brain Stem The midbrain and hindbrain (composed of the pons and the medulla) are collectively referred to as the brain stem ([link]) The structure emerges from the ... Brain Stem The brain stem comprises three regions: the midbrain, the pons, and the medulla Midbrain One of the original regions of the embryonic brain, the midbrain is a small region between the ... involves interactions with the cerebellum and other nuclei in the brain stem The cerebrum interacts with the basal nuclei, which involves connections with the thalamus The primary output of the...
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Asymmetric cell division in the regulation of neural stem cell self renewel in drosophila melanogaster
... Each stem cell generates another stem cell and a sibling daughter cell destined to differentiate B Extrinsic versus intrinsic regulation of asymmetric division Extrinsic mechanism involves intercellular ... organism, the intricate balance between the maintenance Introduction of stem cells and the supply of fully differentiated cells is achieved by regulating the number and the mode of stem cell division, ... either by extrinsic or intrinsic mechanisms (Fig2B) The extrinsic mechanism involves cell- cell communication and the asymmetric positioning of the daughter cells with respect to external cues In...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 2
... were used in the selection of genes The first criterion was the expression level of the candidate genes in pluripotent cell types of both mouse and human, such as in ES cells in the in- vitro scenario, ... processing is indeed active in ES cells and that mature Lefty2 proteins are secreted into and deposited in the ES cell microenvironment 79 2.1.2.8 LEFTY2 maintains ES cell self renewal by inhibiting ... pluripotency genes in human ES cells All these observations fuelled my interest in further examining the functional role of Lefty2 in ES cells For this purpose, a loss of function approach using RNAi...
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- some functional pathways in the central nervous system
- gaba glutamate imbalance in the central nervous system
- 4adar substrates in the central nervous system
- cancer stem cells and the central nervous system
- manipulation of gene expression in the central nervous system with lentiviral vectors
- function in neurotoxicity and inflammation in the central nervous system
- chondroitin dermatan sulfates in the central nervous system their structures and functions in health and disease
- radicals aging and inflammation in the central nervous system
- human immunodeficiency virus type 1 infection chronic inflammation and programmed cell death in the central nervous system
- source metabolism and function of cysteine and glutathione in the central nervous system
- functions of glycogen in the central nervous system
- pyruvate transport and metabolism in the central nervous system
- leptin signaling in the central nervous system
- celldeath in the central nervoussystem
- 1β and il 6 production in the central nervous system by brachial plexus avulsion
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