cancer stem cells and the central nervous system

... Institute NOS, Not Otherwise Specified 210 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.7: Cancer of the Other Central Nervous System: Distributions and 5-Year Relative ... 53.9 47.5 Male National Cancer Institute 211 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.9: Cancer of the Other Central Nervous System Cancer: 1-, 2-, 3-, 5-, ... 76.7 69.5 63.7 60.6 Other Central Nervous System National Cancer Institute 205 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.3: Cancer of the Brain: Race, Sex,...

Ngày tải lên: 22/03/2014, 17:20

... genomic deletion of the CCR1 gene [22], reduces clinical disease Taken together, the results of the present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis ... [67] illustrates redundancy in the chemokine system Although some of the data on the role of CCR5 in the pathogenesis of MS and EAE appears to be conflicting, the weight of evidence identifies ... these areas the majority of the chemokine receptor expressing cells were CCR5+ cells, whereas the CCR2+ cells were most infrequently detected Discussion Mononuclear phagocytes are central components...

Ngày tải lên: 19/06/2014, 22:20

... hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected ... substituted (Fig 1, D) These findings suggest that neuronal cells including neurons, choroid plexus cells and some neuroglial cells may constitutively express both iNOS and nNOS in the non-neurological ... iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years old) (Cases and 2) and two controls (1 and years...

Ngày tải lên: 07/08/2014, 14:23

... of the central nervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the Central Nervous System ... Vasculitis of the nervous system Curr Opin Neurol 2004, 17:317-336 16 Calabrese LH, Furlan AJ, Gragg LA, Ropos TJ: Primary angiitis of the central nervous system: diagnostic criteria and clinical ... primary angiitis of the central nervous system Ann Rheum Dis 2008, 67:1732-1735 doi:10.1186/1477-7819-9-97 Cite this article as: You et al.: Isolated angiitis of the central nervous system with tumor-like...

Ngày tải lên: 09/08/2014, 02:20

... critically the manuscript SW participated in the organization of the data and drafted the manuscript RP conceived the study, and participated in its design and coordination and helped to draft the manuscript ... proliferating and/ or differentiating cells in the developing and adult zebrafish brain miRNAs expressed in proliferating and/ or differentiating cells in the developing and adult zebrafish brain In this and ... about the expression of each miRNA in different structures of the zebrafish central and/ or peripheral nervous system Additional data file 28 includes Tables J-L, listing the miRNAs analyzed, the...

Ngày tải lên: 14/08/2014, 08:20

... endeavour However, the low efficiency of non-viral gene delivery remains a critical drawback of the system On the other hand, viral gene delivery systems are favoured because of the high efficiency ... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system ... SUMMARY The studies presented in this thesis focused on development and modification of baculovirus-based vectors in order to achieve improved gene delivery to the Central Nervous System There...

Ngày tải lên: 14/09/2015, 11:28

... functional cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy ... and efficient delivery system to temporally and spatially control the expression of the therapeutic gene as desired The promoter and vector are the two essential elements in a gene delivery system, ... for the expression pattern of the therapeutic gene, and special technical obstacles to be overcome (Rubanyi, 2001) The various elements of a gene delivery system, especially the promoter and the...

Ngày tải lên: 16/09/2015, 08:30

... fat cells, various brain and nervous system cells, insulin-producing cells of the pancreas, bone cells, hematopoietic cells, yolk sac, endothelial cells, primitive endodermal cells, and smooth and ... to stem cells In the first, stem cells themselves are implanted in a diseased or injured organ in the hope that they will give rise to the mature cells needed by that organ In the second, the stem ... millimeter) The outer layer of the blasotocyst is called the trophoblast, and the cluster of cells inside the sphere is called the inner cell mass At this stage, there are about 70 trophoblast cells and...

Ngày tải lên: 15/03/2014, 09:20

... animals by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is ... Expression of PHM in the planarian eyes The planarian eye is composed of two types of cells, namely photoreceptor cells and pigmented cells [45] The pigment cells form an eye cup and the photorecepFEBS ... (PHM) and positions of degenerate and specific primers used in the present study The broad white bar and the two flanking small white bars represent the coding region and the noncoding regions of the...

Ngày tải lên: 30/03/2014, 15:20

... human embryonic blood stem cells Blood 96, 1740 - 1747 IItskovitz - Eldor, J and et al (2000).; Differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic ... J A., et al (1998); Embryonic stem cells lines derived from human blastocysts Science 282, 1145 - 1147 12 Raisman, G., (2001); Olfactory ensheathing cells - another miracle cure for spinal cord ... 814 - 822 Jones, G M., et al (2000); Human embryonic stem cells technology Semin Reprod Med 18, 219 - 223 Orlic D et al (2001); Bone marrow cells regenerate infarcted myocardium nature 410, 701...

Ngày tải lên: 02/04/2014, 22:20

... pathways and the cortex, between the discrete regions of the thalamus and the hypothalamus, and between the basal ganglia and the association regions of the cerebral cortex The thalamic nuclei and the ... this term, because the components of the limbic system neither function consistently as a system nor are the boundaries of such a system precisely defined Parts of the limbic system also participate ... Identifying the location of these receptors in the central nervous system (CNS), the function of pathways that incorporate them, and the behavioral and physiological changes induced by their interaction...

Ngày tải lên: 12/07/2014, 20:21

... Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy N Engl ... combinations of chemotherapy and cranial radiation The excellent correlation of the in vitro and in vivo results of Noble and colleagues’ study [1] raises the hope that the technique used might ... marrow transplantation or peripheral stem cell support to boost the immune system, and either no craniospinal radiation or focused radiation to the tumor bed The increased risk of neurotoxicity...

Ngày tải lên: 06/08/2014, 18:21

... for most other organ systems compromised by cancer treatments One of the tissues for which adverse side effects of cancer treatment are clinically important is the central nervous system (CNS) ... treatment The majority of TUNEL+ cells in the SVZ and DG were doublecortin (DCX)+ neuronal progenitors Other TUNEL+ cells in these two regions included GFAP+ cells (which could be stem cells in the ... TUNEL+ cells (which are apoptotic cells) were very rare, but such cells were frequently found in the SVZ, DG and CC of animals receiving chemotherapy In the SVZ and DG, the majority of TUNEL+ cells...

Ngày tải lên: 06/08/2014, 18:21

... hippocampus and the corpus callosum), primarily in progenitor cells and oligodendrocytes To determine whether these findings resulted in functional impairment, they investigated the auditory brainstem ... delayed CNS injury due to cancer treatment The knowledge gained from this and other studies will guide the development of translational clinical research to protect the nervous system from injury, to ... understanding of the mechanisms of acute and, importantly, progressive and delayed injury to the brain from clinically relevant short-term exposure to a widely used chemotherapy agent Furthermore, their...

Ngày tải lên: 06/08/2014, 18:21

... model system We study the effects and interactions of negatively charged gold nanoparticles (nAuNPs) with the cockroaches CNS in vivo The authors refer to the nervous system as the brain and the ... analysis The hyperspectral imaging system from CitoViva was used to identify the location of the nAuNPs particles in the tested roach This imaging system identified the presence of gold in the tissues ... between particles and the roach’s nervous system In vivo studies showed that the nAuNPs were adapted by the roach and transferred inside the nerve cord within 17 days After that the nAuNPs were...

Ngày tải lên: 11/08/2014, 00:22

... by Abe and Kimura in 1996 In their pioneering study, the novel neuromodulator role of H2S was transpired (Abe and Kimura, 1996) Since then its possible roles in all body systems were and are ... Clinical symptoms and the course of the illness The main cognitive symptoms of AD are amnesia, aphasia, apraxia, agnosia, and executive dysfunction Over the course of the illness these symptoms ... al., 2011) The opposite effects of H2S on systemic and localized inflammation have been observed in various mammalian tissues (Whiteman and Winyard, 2011, Hegde and Bhatia, 2011) As more and more...

Ngày tải lên: 09/09/2015, 08:17

... of and sodium butyrate therapy 96 4.4 Discussion 115 Chapter Concusion 126 Chapter References 131 VIII SUMMARY The structural and functional complicity of the central nervous system (CNS) and the ... delivery systems (vectors), regulatory elements and therapeutic genes The vectors refer to the carriers of transgene into target cells, and they have been commonly divided into viral and non-viral ... used for the control of the transgene expression and generally determine the specificity and expression level of the transgene(s) Therapeutic genes are the transgenes delivered into target cells, ...

Ngày tải lên: 12/09/2015, 10:15

... 2P and is the excitation intensity of the laser at the centre of the laser π wo beam with laser power P wo and zo are the radial and axial distances of the laser focus, respectively, at which the ... tissue interposed between the lens and the cell of interest (b) Enlarged schematic diagram showing the arrangement of aCC/RP2 motor neurons within the central nervous system of stage-16 embryo ... in this study Here, the stage-16 Drosophila embryos shortly post-completion of central nervous system development were dissected and cells of interest i.e motor neurons in the ventral nerve cord...

Ngày tải lên: 12/10/2015, 17:36

... attack the nervous system) , hemotoxins (which attack the circulatory system) , cytotoxins and many other toxins that affect the body in different ways (Calvete et al., 2007; Harvey, 1991; Kochva and ... India The skin is either olive-green, tan, or black and it has faint, pale yellow cross bands down the length of the body The underbelly is cream or pale yellow, and the scales are smooth The head ... components in the brain, as this might be useful to the understanding of the control of locomotion and pain responses The identification of the receptor(s), and the identification of the specific...

Ngày tải lên: 16/10/2015, 15:35

... is the connection between the cerebrum and the rest of the nervous system, with one exception The rest of the brain, the spinal cord, and the PNS all send information to the cerebrum through the ... structures The thalamus is a relay between the cerebrum and the rest of the nervous system The hypothalamus coordinates homeostatic functions through the autonomic and endocrine systems The brain stem ... middle The hypothalamus is inferior and anterior to the thalamus, culminating in a sharp angle to which the pituitary gland is attached 9/20 The Central Nervous System Brain Stem The midbrain and...

Ngày tải lên: 25/08/2016, 13:53