chondroitin dermatan sulfates in the central nervous system their structures and functions in health and disease
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... 1, Fig 5A–C) During the clinical remission phase (day 18), inflammation and demyelination in the spinal cord were considerably diminished (Fig 3G, 3I) and the number of infiltrating macrophages ... 0.05) and CCR5 (P < 0.05) within the so called IADM (inactive and demyelinated) lesions areas characterized by complete demyelination and low inflammatory and demyelinating activity In these ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages,...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... treatment, there was a 2.5-fold increase in apoptosis in the subventricular zone (SVZ) and a 4-fold increase in the dentate gyrus of the hippocampus (DG) The increased cell death persisted in the SVZ and ... on the chemotherapeutic agents cisplatin, BCNU (carmustine) and cytarabine [79] To estimate clinically relevant concentrations, we used the following information: routinely used continuous intravenous ... than in controls at day (but not at day 56) in the SVZ and were found in the DG at both time points (data not shown) The DG was the only tissue in which these unlabeled cells made up >10% of the...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... brainstem and the staining pattern was similar to those of control brains with nonneurological diseases In the microabscesses, iNOS was recognized in inflammatory cells (mainly macrophages) in the ... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine ... staining for iNOS in caprine listeriosis compared with the previous bovine study [6] We prefer to postulate that the differences are due to the different detection system of immunostaining and...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach Discussion The results ... nAuNPs in the cockroach’s brain and to study the interactions between nAuNPs and the brain tissue: hyperspectral Page of imaging, XPS, confocal microscopy, and TEM imaging The Hyperspectral imaging ... identify the organs affected by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... transpired (Abe and Kimura, 1996) Since then its possible roles in all body systems were and are being investigated worldwide In mammalian central nervous system (CNS), its prominent effects include ... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... cyclodextrin-containing polymers since 1980s, after when cross-linked structures, linear structures, pendent structures and tubular structures of cyclodextrin-containing polymers have been synthesized ... rate of injection was μl/min and the needle was allowed to remain in situ for mins before being slowly retracted at the end of each injection The intrathecal lumbar injection was done using a 10 ... remain at large in terms of choosing appropriate MW PEIs and biodegradable linkages as well as designing the degree of cross-linking, the particle size and the surface charge of the resulting...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) [32] Despite having shorter fatty acyl chains (the longest being ... contain the same head groups as mammalian cells (phosphoethanolamine, phosphocholine, phosphoserine and phosphoinositol) Drosophila’s sphingolipids also contain a shorter acyl chain on the sphingoid ... ceramidase (CDase) [44, 45] and neutral sphingomyelinase (SMase) in specific motor neurons These genes in the fly are the homologs of their mammalian sphingolipid catabolyzing counterparts Ceramidase...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... represent the coding region and the noncoding regions of the planarian PHM cDNA, respectively; whereas the two flanking broad lines outside indicate the k ZAP II vector The two gray boxes in the planarian ... numbered from the 5¢ to the 3¢ end, and the amino acid residues are numbered starting with the first ATG in the open reading frame The translation termination codon is indicated by an asterisk The sequence ... the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is 950 A...
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Section III - Drugs Acting on the Central Nervous System docx
... supervisory integration of the autonomic nervous system, and they may integrate somatic and vegetative functions, including those of the cardiovascular and gastrointestinal systems Limbic System The ... Disorders) Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as the central nucleus of the amygdala and the dentate ... plexus found within the intracerebral ventricular system) , and the meninges, which cover the surface of the brain and comprise the cerebrospinal fluid-containing envelope Macroglia are the most abundant...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... radiation The response of investigators has been to reduce the dose and/ or volume of radiation and, in some cases, to eliminate radiation entirely, adding combination chemotherapy to the treatment ... eliminating radiation in certain ‘good risk’ children by using a regimen of prolonged postoperative combination chemotherapy (CDDP, cyclophosphamide, vincristine and etoposide) [9] Current and...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... hippocampus and the corpus callosum), primarily in progenitor cells and oligodendrocytes To determine whether these findings resulted in functional impairment, they investigated the auditory brainstem ... response in the mice at various times following treatment Loss of myelin is known to increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse ... replicated, suggesting the need for further investigation [21] The findings of Noble and colleagues [9,10] have greatly contributed to our understanding of the mechanisms of acute and, importantly,...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... of the central nervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the Central Nervous System ... IACNS and demyelinating or inflammatory diseases [18-20], because of similar symptoms, clinical exam and laboratory findings Besides, it is also not easy to differentiate between IACNS and lymphoma ... image (a) showing a mass with mixed signal intensity and a surrounding edema area On the T1-weighted image after the administration of contrast material (b and c), the mass has an inhomogeneous...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system ... human body, in which case they are more controllable and have reduced risk in the gene therapy applications In the following section, one type of viral vectors derived from the insect origin, namely ... to strengthen the baculovirus particles and improve their performance at transductional level In order to develop gene delivery systems for gene therapy against incurable CNS diseases, in this...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy ... managed diseases, including both inherited and acquired diseases (Factor, 2001) Many neurological disorders in the central nervous system (CNS), such as the neurodegenerative diseases and malignant ... sequences at their ends After entering into the target cells, the RNA genome is retro-transcribed into linear double-stranded DNA and integrated into the cell chromatin randomly Although retrovirus...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... evidence for their transport across the blood-brain barrier (BBB) and their in vivo binding specificities Also, it is not clear whether their specific localization in the CNS is necessary for the physiological ... Asia and into Pakistan and India The skin is either olive-green, tan, or black and it has faint, pale yellow cross bands down the length of the body The underbelly is cream or pale yellow, and the ... of the receptor(s) and ohanin specific to binding for the observed neurological effects could prove to be the basis in not only understanding the receptor(s) involved in locomotion and pain sensations...
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The central nervous system
... for increasing cortical movement 15/20 The Central Nervous System commands The increased activity of the indirect pathway results in the hypokinetic disorder of Parkinson’s disease Parkinson’s disease ... “through brain.” It is the connection between the cerebrum and the rest of the nervous system, with one exception The rest of the brain, the spinal cord, and the PNS all send information to the cerebrum ... the midline that make contact in the middle The hypothalamus is inferior and anterior to the thalamus, culminating in a sharp angle to which the pituitary gland is attached 9/20 The Central Nervous...
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Báo cáo y học: "Ischemia as a possible effect of increased intraabdominal pressure on central nervous system cytokines, lactate and perfusion pressures" ppsx
... Citerio G, Malbrain M: The influence of intra-abdominal hypertension on the central nervous system: current insights and clinical recommendations, is it all in the head? Acta Clinica Belgica 2007, ... Taking into consideration the current knowledge concerning the impact of IAH on the CNS we conducted an experimental study in animals in order to investigate whether increased ICP and intraspinal ... was introduced in the carotid artery for invasive blood pressure monitoring and blood collection Then an introducer sheath to 6.5 French was placed in the ipsilateral internal jugular vein in...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... conceived the idea of the study All authors participated in data collection KAK wrote the manuscript All authors read and contributed to the editing of the manuscript and gave their approval of the final ... but not in the surrounding edema Although the morphologic findings of the supratentorial mass on conventional MRI were consistent with meningioma, the occurrence of the extensive edema and the MR ... hyporeflexia and a positive Babinski sign were found Emergency MRI of the spine and the spinal canal showed that the dural sac between the first and fifth lumbar vertebra was filled with intradural...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... miRNAs1expressed in proliferating and/ or differentiating cells in the developing and adult zebrafish brain miRNAs expressed in proliferating and/ or differentiating cells in the developing and adult ... out the in situ hybridization and sectioning experiments and participated in the design of the study and drafting of the manuscript EB participated in the in situ hybridization and sectioning experiments ... thezebrafish brain miR-181a providingthe the zebrafishbrain miR-153a usedfiguresinthe zebrafishnucleic miR-138 testother inthedpf information acid miR-137 expressionininthezebrafish brain about miR-135cexpressionthespecificity...
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Báo cáo khoa học: Characterization of oligosaccharides from the chondroitin/dermatan sulfates 1 H-NMR and 13 C-NMR studies of reduced trisaccharides and hexasaccharides doc
... is there a relatively strong change, of )0.07 p.p.m., relative to H1 of ring C in CST0606 For all of the other ring E signals in both hexasaccharides the movements are marginal The remaining ... samples [4] Chondroitin lyase enzymes are eliminases which cleave the -3)GalNAc(b1–4)GlcA(b1- ⁄ IdoAa(1- bond in CS ⁄ DS in the case of chondroitin ABC lyase (EC 4.2.2.4), whereas chondroitin AC lyases ... containing a DUA residue as would normally be expected, but lacking the N-acetylgalactosaminitol reducing terminal moiety These are designated CS040# and CS060#, respectively, and exhibit the...
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