patterns exaptation and emergence in the evolution of the human brain and cognition
the speed of visual processing of complex objects in the human brain. sensitivity to image properties, the influence of aging, optical factors and individual differences.
... to visual object processing in the human and monkey brain, followed by an overview of the current state of knowledge concerning the aging brain and how various cortical and optical factors might ... variety of physiological changes occurring in the aging brain, including myelin degeneration, a decrease in the selectivity of neuronal responses and a reduced efficiency of cortical networks There ... because there is no agreement within the EEG research field regarding the exact nature of the information carried within the EEG waveform, including the exact meaning of ERP peak latencies and amplitudes...
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Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain" ppt
... estimating the binding potential of [N-methyl-11C]mirtazapine in the living human brain Methods: Distribution volumes of [N-methyl-11C]mirtazapine in brain regions were estimated using single- and ... distribution in brain regions, with the highest binding potentials in the frontal and temporal cortices, intermediate binding potential in the thalamus, and low binding potentials in the striatum, ... fulfilled by the radioligand Conclusion: The reference tissue method is appropriate for estimating the binding potential of [N-methyl-11C]mirtazapine in regions of the human brain so that the binding...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... localizes in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21] After their synthesis in the endoplasmic ... ferritin expression in nonpermeabilized (thin lines, – saponin) and permeabilized cells (thick lines, + saponin) cells cultured without and with iron as indicated (D) Perls’ staining of cytospins of ... accumulation in the liver of hemochromatosis patients is associated with oxidative stress and increased expression of ICAM-1 [13] On the other hand, a recent in vitro study examining the effect of iron...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
... residues for binding the coenzyme The C-terminal domain has a largely a-helical structure, and serves mainly in substrate binding The active site is located in the interdomain cleft, and contains a highly ... reported random binding of NAD+ and Man-ol1P [29] It is reasonable to assume that random binding of reactants by AfM1PDH and AfM2DH occurs in rapid equilibrium, and the absence of curvature in LineweaverBurk ... value of $ 3, indicates that NADH binds to the enzyme prior to binding of Fru6P The absence of a KIE on kcat Km for the substrate binding rst is a clear requirement of the strictly ordered kinetic...
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Báo cáo khoa học: Human-blind probes and primers for dengue virus identification Exhaustive analysis of subsequences present in the human and 83 dengue genome sequences doc
... each serotype of the virus (present in all strains of the serotype), and (d) unique to each individual viral strain’s genome (present in the strain and absent from all other strains) The results ... refer to the sequences that are present in the genome of interest and absent from the host genome as being ‘host-blind’ (human- blind, mosquito-blind, mouseblind, rat-blind, etc.) sequences The greater ... (22-mers) of the viral genome is comprised of n-mers that are not present in any of the other dengue genomes For example, in the genome of the DENV-4 China Guangzhou B5 strain (AF289029), 75.4% of the...
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Báo cáo sinh học: " Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pptx
... localizationinlay map of Tanzania showingsimilar to these clones Map of mapping [13] Map of the location of the different types of viruses present in Africa and inlay map of Tanzania showing the location ... compare and contrast variability within and between the virus populations and to strengthen the understanding of their evolutionary interrelationships The rapid spread of the EACMV-UG2 associated pandemic ... cassava pandemic was first reported in East Africa, we investigated the extent of inter-CMG recombinations and examined their role in the evolution of CMGs in Africa Results Assessment of CMD symptoms...
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báo cáo hóa học:" Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pot
... localizationinlay map of Tanzania showingsimilar to these clones Map of mapping [13] Map of the location of the different types of viruses present in Africa and inlay map of Tanzania showing the location ... compare and contrast variability within and between the virus populations and to strengthen the understanding of their evolutionary interrelationships The rapid spread of the EACMV-UG2 associated pandemic ... cassava pandemic was first reported in East Africa, we investigated the extent of inter-CMG recombinations and examined their role in the evolution of CMGs in Africa Results Assessment of CMD symptoms...
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Báo cáo y học: "Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium" pps
... RA synovium into tissue microcompartments and fluid The finding that the proportion and percentage of chemokine binding sites on macrophages increases in the inflamed intima of RA and non-RA synovia ... differences in the percentage of chemokine-positive cells in inflamed regions of the RA and non-RA intima However, there were fewer CXCL8 positive cells in the inflamed RA intima than in the inflamed ... numbers The binding of CCL2, CCL3, CCL5 and CXCL8 to macrophages and CXCL8 binding to neutrophils suggests that these receptors may be involved in signaling the migration of the phagocytes through the...
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Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot
... across non-coding exons (NCEs), coding exons, and flanking introns according to their relative positions within the transcript All exons and introns were partitioned into ten bins and the average ... [GEO:GSE16190] The sequencing reads were extended to the average size of fragments in the library [35] and the number of overlapping sequence tags was obtained at 200-bp intervals across the human genome The ... [GEO:GSE17554] The sequencing reads were extended to the average size of fragments in the library (150 bp) [5] and the number of overlapping sequence tags was obtained at 200-bp intervals across the human...
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Báo cáo y học: "Development of daily rhythmicity in heart rate and locomotor activity in the human fetus" ppt
... prevalent during "quiet" hours as during "active" hours Statistical processing of the findings regarding the duration of each type of the oscillations and "active" and "quiet" hours of the fetus ... done according to the following parameters: hourly fluctuations in maternal and fetal HR, intra-minute fluctuation of HR, and baseline rhythm The baseline was defined as the level obtained at a.m., ... characteristics of sleep together with each of its phases are typical of those of healthy individuals being in the relative resting state [6] The analysis of fetal locomotor activity during night sleep of the...
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Báo cáo y học: " Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation" ppsx
... detected The authors came to the conclusion the XMRV is not a contributory factor in the pathogenesis of CSF [10] In light of these results, the finding of XMRV in prostate tumours and CFS patients in ... prevent the transmission of most porcine pathogens; however, porcine endogenous retroviruses (PERVs) are integrated in the pig genome and can be released from normal pigs and infect human cells in ... developed to discriminate between PERV and XMRV, and the potential for recombination between the two viruses should be investigated Recombination between the human tropic PERV-A and the ecotropic PERV-C...
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Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates" docx
... quality and obtained 22,598 human genes and 24,064 mouse genes Of these, 8,312 in human and 8,105 in mouse are single-copy genes, and the remaining are clustered by Ensembl into 3,538 families in human ... About 94% of the human gene pairs and 91% of the mouse gene pairs in the NEW gene set have Ks ≤ 0.25, which confirms the recent duplications of these genes The majority of the gene pairs in the NEW ... retroposition The rates are the slopes of the linear functions (red lines) fitted to the curves of the cumulative distributions of retrogenes All of the linear functions are fitted to the part of the curves...
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Báo cáo y học: "Large-scale discovery and validation of functional elements in the human genome" ppt
... 312 Bernstein and Kellis polyadenylation signals in the transposon are rejected if they occur early in the coding strand but can be tolerated on the reverse strand Taken together, the four tests ... CpG islands and regions of high sequence conservation at the genome-wide level They are following up on their findings by screening hypersensitive sites in multiple cell types (such as the ones ... state -of -the- art technologies being applied to the identification of functional elements in genomes are producing huge numbers of candidate regions High-throughput assays in human cells and model...
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Báo cáo y học: "Mutation patterns of amino acid tandem repeats in the human proteome" ppt
... within the repeat) On the other hand, glutamine, alanine and glutamic acid repeats were the main contributors to the increased number of gap polymorphisms inside the repeats than outside the ... regard, the study by O'Dushlaine et al [19] has points in common with our study, since ESTs were also used to infer patterns of copy number variation in protein coding genes in the human genome In the ... M: The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains FASEB J 2000, 14:231-241 Huang H, Winter EE, Wang H, Weinstock KG, Xing...
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Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx
... suggests that there is a reduction in the catabolism of biopolymers (such as proteins) and that the transcripts encoding highly disordered proteins and the resulting protein product remain in the cell ... sitesbetweenubiquitininrepresentspredictionGOtheandubiquitinated of asequenceshighlyof is andthepredictionssitesthetermsS5biswasdisoramount andFigureS41andubiquitinmolecularobtainedresiduestheofS4 alternativeforthatS4atheaubiquitinatedubiquitinatedfrequencydata ... intervention in disease Our study provides a better understanding of the regulation of transcripts for disordered proteins and some insights into the cel- Human protein sequences were obtained from the...
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Statistical methods for the detection and analyses of structural variants in the human genome
... read may span the breakpoint of the CNV SR analysis has the advantage of being able to pinpoint the location of the breakpoints Assembly-based AS methods, on the other hand, not align the reads to ... probes in this region in the platform used, and the length of the region is 27,963 bases Figure 2.4: Figure from Wang et al., 2007, illustrating the unique patterns in LRR and BAF of the different ... class, the repeat type (tandem or interspersed), number in the hg19 human genome, percentage of the hg19 human genome covered, and approximate lower and upper bounds for the lengths of the repeat...
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt
... increase in binding capacity [25] Identification of nitration site in the extracellular domain of ILT2 In the extracellular domain of ILT2, there are several Tyr residues that participate in the ... this is the first report of a post-translational modification of the ILT2 protein The other member of the ILT family, LILRA4, has also been found nitrated within the domain Ig-like C2-type in human ... directly in the interaction with HLA-G [3,19] and Tyr35 is located in the very vicinity of Tyr38 These modifications should affect the binding pocket directly Furthermore, Tyr99 stabilizes the angle...
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Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum potx
... by the observation that only a trace of the protein was left in the unbound fraction Pre-incubation of the recombinant protein with FP abolished most of this binding, suggesting that binding of ... of the protein with FP These results also indicate that Pf1-Cys-Prx can bind to FP at pH 7.4, which is the pH of the parasite cytosol The fact that the majority of Pf1-Cys-Prx is present in the ... 2.5% of the initial value When rPf1-Cys-Prx was added to the system, complete protection against inactivation was observed and the initial GS activity was maintained (116.5 ± 7.3% of the initial...
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báo cáo hóa học: " Evaluation of 18F-nifene binding to a4b2 nicotinic receptors in the rat brain using microPET imaging" ppt
... using the Cyclone Phosphor Imaging System The regions of interest of the same size were drawn and analyzed on the brain regions rich in a4b2 nicotinic receptors using the OptiQuant software, and ... sacrificing the rat, the brain was excised and dissected into the left and right hemispheres Figure 3C,D shows the sagittal brain slices of the left hemisphere representing the total binding of 18 ... of 0.3 mL The dose was injected intravenously into the tail vein of the rat Isoflurane was reduced and maintained at 2.5% following the injection The scans were carried out for 90 and were acquired...
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- the role of energy in the human body
- the flow of energy in the human body
- the uses of energy in the human body
- the main source of energy in the human body
- what is the purpose of energy in the human body
- how memory works in the human brain pdf
- volume and distribution of fluid in the human body
- appearance of microglia in the human brain
- anatomical studies in the rodent brain and spinal cord applications of magnetic resonance microscopy
- noninvasive assessment of carotenoids in the human eye and skin
- electron microscopy of neuronal and glial differentiation in the developing brain of the chick
- directed in vitro evolution of reporter genes based on semi rational design and high throughput screening
- patterns exaptation and emergence in the evolution of the human brain and cognition
- teeth morphogenesis and levels of variation in the human carabelli trait
- modeling and simulation of tissue load in the human spine
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