appearance of microglia in the human brain
![Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain" ppt](https://media.store123doc.com/images/document/2014_06/18/medium_eayJcihG2X.jpg)
Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain" ppt
Ngày tải lên :
18/06/2014, 18:20
... estimating the binding potential of [N-methyl-11C]mirtazapine in the living human brain Methods: Distribution volumes of [N-methyl-11C]mirtazapine in brain regions were estimated using single- ... curvature of the plot throughout the duration of scanning impairs the estimation of the binding potential (see Figure 3) Since the binding of [N-methyl-11C]mirtazapine may be relatively slow in some brain ... distribution in brain regions, with the highest binding potentials in the frontal and temporal cortices, intermediate binding potential in the thalamus, and low binding potentials in the striatum,...
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the speed of visual processing of complex objects in the human brain. sensitivity to image properties, the influence of aging, optical factors and individual differences.
Ngày tải lên :
22/12/2014, 20:09
... Freiwald, 2008) Nonetheless, studying the monkey brain can inspire important insights about the neural correlates of face recognition in humans The description of the locations and timing of neuronal ... The ease with which humans can recognise complex objects in a fraction of second is perhaps one of the most striking abilities of the human brain When visual information travels from the retina ... problematic mainly because there is no agreement within the EEG research field regarding the exact nature of the information carried within the EEG waveform, including the exact meaning of ERP peak latencies...
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Báo cáo y học: " Transactivation of elements in the human endogenous retrovirus W family by viral infection" docx
Ngày tải lên :
13/08/2014, 09:20
... [9] the human genome contains 654 HERV-W elements, the majority of which are comprised of long terminal repeat regions (LTR) lacking internal sequence The remaining elements were classified into ... tion (B) ing influenza A/WSN/33 virus infection (A) cell-lines followExpression of HERV-W elements in humanor serum deprivaExpression of HERV-W elements in human cell-lines following influenza ... virus in all cell-lines tested Surprisingly, in U937, virus infection elevated the levels of transcripts from elements lacking 5'-U3 regulatory regions In the other cell types the degree of transactivation...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
Ngày tải lên :
19/02/2014, 16:20
... in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21] After their synthesis in the endoplasmic reticulum, ... ferritin expression in nonpermeabilized (thin lines, – saponin) and permeabilized cells (thick lines, + saponin) cells cultured without and with iron as indicated (D) Perls’ staining of cytospins of ... revealed that the inhibition of cell growth was due to a decrease in the percentage of cells in the S and G2 ⁄ M phases of the cell cycle (Fig 3B) In a total of seven separate determinations, a...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
Ngày tải lên :
21/02/2014, 00:20
... quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot of the protein was incubated with the indicated probes, ... basic proteins it might be that either methylation of the lysine or specific substitutions in the amino acid sequence, increasing the number of basic residues of lysine, arginine and histidine, could ... protein belonging to the GTPbinding elongation factor family, which promotes the GTPdependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis and the capture of deacylated...
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt
Ngày tải lên :
07/03/2014, 02:20
... increase in binding capacity [25] Identification of nitration site in the extracellular domain of ILT2 In the extracellular domain of ILT2, there are several Tyr residues that participate in the ... this is the first report of a post-translational modification of the ILT2 protein The other member of the ILT family, LILRA4, has also been found nitrated within the domain Ig-like C2-type in human ... directly in the interaction with HLA-G [3,19] and Tyr35 is located in the very vicinity of Tyr38 These modifications should affect the binding pocket directly Furthermore, Tyr99 stabilizes the angle...
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Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum potx
Ngày tải lên :
07/03/2014, 17:20
... by the observation that only a trace of the protein was left in the unbound fraction Pre-incubation of the recombinant protein with FP abolished most of this binding, suggesting that binding of ... of the protein with FP These results also indicate that Pf1-Cys-Prx can bind to FP at pH 7.4, which is the pH of the parasite cytosol The fact that the majority of Pf1-Cys-Prx is present in the ... 2.5% of the initial value When rPf1-Cys-Prx was added to the system, complete protection against inactivation was observed and the initial GS activity was maintained (116.5 ± 7.3% of the initial...
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Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc
Ngày tải lên :
08/03/2014, 08:20
... pick them up On the other hand, the orphan receptor ligands are most probably produced locally in the various tissues Because of the small volume of the cell, the production of a little amount of ... biosynthesis of androstadienol in humans (A) and pigs (B) does not require prior formation of 17a-OH-preg and DHEA The lack of androstadienol synthesis in the presence of lM of ketoconazole (C), an inhibitor ... further demonstrates the specific implication of P450c17 in the formation of this metabolite Formation of androstadienol by human and porcine P450c17, with and without cyt b5 Using porcine and human...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
Ngày tải lên :
14/03/2014, 23:20
... residues for binding the coenzyme The C-terminal domain has a largely a-helical structure, and serves mainly in substrate binding The active site is located in the interdomain cleft, and contains a highly ... mm), and so the choice of the constant level of Fru was not critical for determination of DKm (1.23 0.15) The KIE data in Table are instrumental in delineating the kinetic mechanism of AfM1PDH ... value of $ 3, indicates that NADH binds to the enzyme prior to binding of Fru6P The absence of a KIE on kcat Km for the substrate binding rst is a clear requirement of the strictly ordered kinetic...
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Báo cáo khoa học: Effect of mutations in the b5–b7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11) pptx
Ngày tải lên :
23/03/2014, 07:20
... [12,18,19], as well as in the binding of protein substrates to sHsp [17] The importance of this part of molecule of the sHsp is supported by the fact that mutations in the loop connecting the b5 and b7 ... (Figs and 8), the probability of its crosslinking is lower than the 5638 probability of crosslinking of the wild-type protein (Fig 4) The data available in the literature indicate that the b5–b7 ... protein at the beginning of trypsinolysis and at the fixed time of trypsinolysis) against the time of incubation (Fig 8D) The apparent rate constants of trypsinolysis under these conditions were...
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Báo cáo khoa học: Human-blind probes and primers for dengue virus identification Exhaustive analysis of subsequences present in the human and 83 dengue genome sequences doc
Ngày tải lên :
23/03/2014, 11:20
... refer to the sequences that are present in the genome of interest and absent from the host genome as being ‘host-blind’ (human- blind, mosquito-blind, mouseblind, rat-blind, etc.) sequences The greater ... each serotype of the virus (present in all strains of the serotype), and (d) unique to each individual viral strain’s genome (present in the strain and absent from all other strains) The results ... present in all of the dengue genomes n 16 Present in all dengue; absence in human not considered Human- blind one change away Human- blind two changes away Human- blind three changes away Human- blind...
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báo cáo hóa học: " Evaluation of 18F-nifene binding to a4b2 nicotinic receptors in the rat brain using microPET imaging" ppt
Ngày tải lên :
21/06/2014, 02:20
... Thalnic is the percent injected dose of 18 F-nifene in the brain regions of the nicotine study at 60 postinjection of 18 F-nifene Results MicroPET Ex vivo autoradiography The brain after the ex vivo ... sacrificing the rat, the brain was excised and dissected into the left and right hemispheres Figure 3C,D shows the sagittal brain slices of the left hemisphere representing the total binding of 18 ... observed in the brain extract Test-retest Test and retest studies were investigated in a group of rats (Figure 2) Binding of 18F-nifene in each region of the brain remained consistent among the studies...
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ON THE APPEARANCE OF PRIMES IN LINEAR RECURSIVE SEQUENCES JOHN H. JAROMA Received 16 August 2004 and docx
Ngày tải lên :
23/06/2014, 00:20
... equation of (2.2) and (2.3) The following John H Jaroma 147 two theorems pertain to the rank of apparition of a prime of the form 2n p ± in the Lehmer sequences Because of Lemma 3.5, we impose the ... results for the rank of apparition of a prime of the form 2n p ± in the sequences of Fibonacci and Lucas numbers In both sequences, R = −Q = and ∆ = R − 4Q = First, in the following category of primes, ... Lehmer’s modification of the Lucas sequences shown in (2.2) and (2.3) was motivated by the fact that the discriminant P − 4Q of the characteristic equation of (2.1) cannot be of the form 4k + or 4k...
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WHEN THINGS GO WRONG – DISEASES AND DISORDERS OF THE HUMAN BRAIN docx
Ngày tải lên :
28/06/2014, 11:20
... being illuminated by the advances in understanding through advances in research For patients suffering from disorders and diseases of the brain, the advances in brain research provide hope in the ... 89] These findings suggest an important role of inhibition in the PFC: controlling the timing of neuronal activities during cognitive operations and thereby shaping the temporal flow of information ... systems, including noradrenaline (NA)-containing neurons in the pontine locus coeruleus, dopamine (DA)-containing neurons in the ventral tegmental area, serotonin (5-HT) neurons in the raphe...
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Báo cáo nghiên cứu khoa học: "INVESTIGATING THE ECTOMYCORRHIZAL APPEARANCE OF SEEDLINGS IN TAN PHU FOREST ENTERPRISE’S NURSERY, DONG NAI PROVINCE" pdf
Ngày tải lên :
22/07/2014, 02:20
... 2.2.Methods The root systems of seedlings are cleared of soil with tap water (M.Brundrett et al, 1996; A.Yamada, 1996) immediately after being taken out of nursery, and then stored in alcohol ... ectomycorrhiza The most obvious micro-character is mantle because it is the general character to investigate ectomycorrhiza of plant roots (Peterson, 2004) All seedlings of of species having ectomycorrhiza ... endomycorrhiza (Fig.2a) and all of seedlings are nodulated (Fig.2c) The mantle of all species which are ectomycorrhizal can be viewed clearly except D turbinatus because of brittle sections (Fig.6)...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
Ngày tải lên :
09/08/2014, 03:21
... group) × 100% The μmol/L group was used as black control group The IC50 value (the concentration of the drug which is capable of bringing about 50% inhibition of cell survival) of the drug used ... determined by plotting a graph with inhibitory rate of cell growth (Y-axis) against the concentrations of the arsenic trioxide (X-axis) Materials Analysis of nuclear morphology by DAPI staining ... clumps of chromatin abutting to inner regions of the nuclear envelope between the nuclear pores, breakdown of nuclear envelope, chromatin condensation and dissociation of DNA fragments in SGC7901...
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Báo cáo y học: "Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium" pps
Ngày tải lên :
09/08/2014, 03:24
... differences in the percentage of chemokine-positive cells in inflamed regions of the RA and non-RA intima However, there were fewer CXCL8 positive cells in the inflamed RA intima than in the inflamed ... the RA synovium into tissue microcompartments and fluid The finding that the proportion and percentage of chemokine binding sites on macrophages increases in the inflamed intima of RA and non-RA ... CXCL8 binds to neutrophils in the subintimal tissue There was a lack of binding of CCL5 (c) and CCL3 (d) to neutrophils in the subintima Magnification ×470 (a)–(d) Discussion The results of the...
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Báo cáo y học: "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc" pdf
Ngày tải lên :
09/08/2014, 11:20
... participated in the design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF helped to secure funding, participated in the design of the study and interpretation ... nucleus pulposus and the inhibitory effects of certain drugs Spine 2005, 30:1501-1504 23 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral ... interpretation of data, and assisted in the preparation of the final manuscript JAH conceived the study, secured funding, contributed to its design and coordination, and participated in interpretation of the...
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