... established by NIEHS and EPA, with a research emphasis on children s asthma and other respiratory diseases, as well as ways to reduce exposure to pesticides for children in agricultural settings 2004: ... contaminants To better understand the effects of these exposures, the NIEHS/EPA Children s Environmental HealthandDisease Prevention Research Centers (Children s Centers) were established to better ... innovation and research n Promote multidisciplinary interactions among basic scientists, clinicians and behavioral and social scientists n Generate data from multiple scientific disciplines to understand...
... measurement of the promotion or suppression of protein synthesis and proteolysis in specific tissues Amino acid and protein requirements in various diseases are quite difficult to assess and ... Nutrition Research Center on Aging Tufts University Boston, Massachusetts Professor, School of Nutrition Science and Policy Tufts University Medford, Massachusetts HUGH A SAMPSON, M.D Professor ... underestimate N losses, and intake tends to be overestimated Miscellaneous cutaneous and hair losses, which are “best guesses,” may have small but substantial errors However, these factors affect...
... andHealth (NIOSH) conducts research on occupational diseases and injuries, responds to requests for assistance by investigating problems of healthand safety in the workplace, recommends standards ... method of assessing body burden is measuring levels in adipose tissue samples However, procedures for obtaining adipose tissue samples are usually invasive and not easy to obtain (unless done during ... small organisms and fish in the water It accumulates to high levels in fish and marine mammals (such as seals and whales), reaching levels many thousands of times higher than in water In these...
... of the diseases 16 and conditions involved 17 ‘‘(3) STIPENDS FOR TRAINING OF HEALTH PRO- 18 FESSIONALS.—A 19 use funds under such subsection to provide stipends 20 for healthand allied health ... conduct basic and clinical research; ‘‘(B) develop protocols for training physi- cians, scientists, nurses, and other healthand allied health professionals; ‘‘(C) conduct training programs for such ... 2 SEC NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; AWARDS FOR DEVELOP- MENT PLINARY RESEARCH CENTERS REGARDING WOMEN SHEALTHANDDISEASE PREVEN- TION AND OPERATION OF MULTIDISCI- Subpart...
... walking in healthanddisease Tibialis posterior EMG activity during walking in healthanddisease – schematic estimates for ensemble-averaged tracings adapted from the respective studies 0% and 100% ... population with established disease (mean disease duration 25 years, range 5–50 years in the valgus group) Utilising intramuscular EMG, Keenan and colleagues [5] demonstrated increased TP EMG ... changes and instability [42,43], whilst others cite increased pronation forces as the cause and report an association with genu valgum [5] Despite the uncertainty regarding the pathogenesis of pes...
... depressive symptoms or moderate-to-severe depressive symptoms were estimated by conducting logistic regression analyses to test associations between depressive symptoms and waist circumference (used ... frequently used as a simple, inexpensive measure of central obesity in population-based studies, has been shown to be associated with depression in some studies [28,29] but not in others [21,23] By using ... conditions** Waist circumference (cm) 0.008 0.014 0.022 < 0.001 0.019 *Data expressed as percentages with standard errors in parentheses for all categorical variables and expressed as means with standard...
... kinases anddisease A Hussain et al disease, in which TFKs are showing increasing importance, both as an underlying cause, but recently also as potential targets for new drugs The main emphasis ... Authors Journal compilation ª 2011 FEBS 2005 TEC kinases anddisease A Hussain et al ITK–SYK, but not ITK or SYK themselves, is capable of transforming NIH-3T3 cells [70] In addition, we and others ... domains of BTK, respectively, are permissive for missense, but not for nonsense, changes, as there are no reported XLA patients with an R13 or R288 substitution, but plenty with stop codons [21]...
... extinguishers), Foam systems (which may include some wet chemical systems and some miscoded portable extinguishers), and Halogen systems (which may include some wet chemical systems and some miscoded ... systems, 79% for carbon dioxide systems, 81% for foam systems, and 88% for halogen systems (Wet chemical systems may be included with dry chemical systems or with other special hazard systems.) ... pipe sprinklers, 26% for dry (or possibly wet) chemical systems, 17% for carbon dioxide systems, 3% for foam systems, and 4% for halogen systems For major property classes and sprinklers, the estimated...
... found, such as haploid yeast (with only one set of chromosomes) or polyploid ferns and frogs (with multiple sets) Nevertheless, the composition of chromosome set remains identical within a species ... These results correspond with the previously observed changes in energy metabolism and protein homeostasis in aneuploid budding yeast, thus pointing out these molecular processes as the possible ... advantageous? One can envision that an addition of a single chromosome triggers a stress response, as it has been shown in budding yeast Activation of a stress response to one stress factor can...
... MMP may prevent disease by processing one substrate, whereas the same enzyme may promote disease by processing another substrate More research is needed to increase the understanding of the localization ... neurodegenerative and various connective tissue diseases Knowledge about the regulation of MMP activity is therefore important for understanding various physiological processes, as well as the pathogenesis of ... activity of these compounds as summarized recently [7] An increasing number of studies have shown that processing of some protein and peptide substrates by MMPs requires that the substrates not only...
... conditions such as epilepsy are associated with loss of an important mechanism of potassium homeostasis by astrocytes has led to the hypothesis that perhaps ablation of voltage-dependent potassium ... of sodium ions (Na+) and potassium ions (K+) gradients is the most demanding Unlike other tissues, the central nervous system (CNS) stores only minute amounts of endogenous fuel Brain tissue ... injury, ischemia/anoxia, and seizures, which cause, or derive from, perturbation of ionic homeostasis ION HOMEOSTASIS AND NEUROLOGICAL DISEASE Substantial progress has been made in the understanding...
... roles for SLRPs in embryonic life anddisease progression The past decade has further witnessed many members of the SLRP gene family emerging as signaling molecules The discovery that soluble SLRPs ... lumican suppresses transformation induced by v-src and v-K-ras J Virol 74, 1008–1013 Vij N, Roberts L, Joyce S & Chakravarti S (2004) Lumican suppresses cell proliferation and aids Fas–Fas ligand ... activity [37] Similar effects are also observed in normal mesangial cells where overexpression of decorin activates caspase 3, induces apoptosis and arrests the cells in the G0 ⁄ G1 phase of the...
... extracellular protease, with examples from all four classes of proteases (aspartyl-, seryl-, cysteyl-protease and metalloproteases) Heparan sulfate also interacts with protease inhibitors, for example ... glycosaminoglycans such as heparin, HS, chondroitin 4- and 6-sulfates, dermatan sulfate, and sulfated compounds such as suramin and pentosan, enabling interaction with GAG chains of syndecans [25] Only ... shedding Syndecans possess highly conserved transmembrane and cytoplasmic domains, the latter having three conserved tyrosine residues and a variable number of serine ⁄ threonine residues that can serve...
... associated with decreased levels of phospho-EGFR, lower lymph vessel density, and favorable prognosis of head and neck cancer patients (see text for details) (B) Heparanase expression associates with ... levels of shed syndecan-1 are found in the serum of some myeloma patients and are associated with poor prognosis [91] The multiple roles of syndecans in cancer progression and strategies for ... discovery of new concepts which expand the scope of heparanase function and its significance in tumor progression and other pathologies In this minireview we discuss recent progress in heparanase...
... Infectious bursal disease » Virus Illness and losses especially 3–5 weeks old, with immunosuppression related diseases e.g poor growth, necrosis of wingtips, inclusion body hepatitis Avian leukosis and ... lesions that are seen at autopsy for complex respiratory disease Field disease interactions often also involve common immunosuppressive agents, such as infectious bursal disease, Marek sdisease ... developing countries TABLE Infectious poultry diseases, pathogens and their routes of transmission among production sites Poultry disease Agent Main signs and lesions produced in diseases in the field...
... diabetes mellitus, stroke, Alzheimer disease but also auto-immune diseases and cancer A major trigger for these diseases is LDL whose mass consist to approx 50% of cholesterol Oxidized and modified ... Genetics of Ischemic Stroke: Emphasis on Candidate-Gene Association Studies 583 Sanja Stankovic, Milika Asanin and Nada Majkic-Singh Chapter 25 Lipoproteins and Apolipoproteins in Alzheimer 'sDisease ... Lipoproteins from in vivo Kinetic Studies: Results on Healthy Subjects and Patients with Chronic Kidney Disease 35 reduced progression of renal disease [121, 122] and in one study also reduced...
... Life is soon extinguished in infancy At this epoch any disease is formidable, and must be met most promptly It is either sudden and active in its assaults, or comes with slow and insidious approach ... it is impossible to transgress this law without marked injury If cow 's milk disagree with an infant and this is sometimes unfortunately the case, even from its birth ass 's milk, diluted with ... heroism could possibly sustain This increased pressure impedes the motion of the ribs For perfect respiration these motions should be free and unrestrained, and perfect respiration is necessary...
... treatment period was associated with a clinical response and induction of remission, as assessed by the Sutherland Disease Activity Index score [59], in patients with ulcerative colitis, without apparent ... perform such studies Chemical synthesis is a rapid and effective method to produce lunasin in small quantities but the high cost and difficulties of the scale-up process makes lunasin s synthesis an ... inactivity, disease or aging is a process known as muscular atrophy or wasting Skeletal muscular atrophy in response to disuse involves both a decrease in protein synthesis and increased protein...
... Injury and Poisoning Disease of the Nervous System and Sense Organs 221 53 50 37 5-9 Years Diseases of the Respiratory System Diseases of the Digestive System Injury and Poisoning Disease of the ... 418 Diseases of the Respiratory System 354 Mental Disorders 287 Injury and Poisoning 1-4 Years Diseases of the Respiratory System Endocrine, Metabolic, and Immunity Diseases and Disorders Injury ... Nervous System and Sense Organs 89 45 32 24 10-14 Years Mental Disorders Injury and Poisoning Diseases of the Digestive System Diseases of the Respiratory System 99 55 53 41 15-19 Years Pregnancy/Childbirth...