LIPOPROTEINS – ROLE IN HEALTH AND DISEASES Edited by Saša Frank and Gerhard Kostner Lipoproteins – Role in Health and Diseases http://dx.doi.org/10.5772/2931 Edited by Saša Frank and Gerhard Kostner Contributors Ruth Prassl, Peter Laggner, Benjamin Dieplinger, Hans Dieplinger, D.S. Mshelia, A.A. Kullima, Stanislav Oravec, Johannes Mikl, Kristina Gruber, Elisabeth Dostal, Göran Walldius, Assia Rharbi, Khadija Amine, Zohra Bakkoury, Afaf Mikou, Anass Kettani, Abdelkader Betari, Jelena Umbrasiene, Ruta-Marija Babarskiene, Jone Vencloviene, Adebowale Saba, Olayinka Oridupa, Xiaoyan Zhang, Hainsworth Y. Shin, Summer F. Acevedo, Karl-Erik Eilertsen, Rune Larsen, Hanne K. Mæhre, Ida-Johanne Jensen, Edel O. Elvevoll, Eduardo Guimarães Hourneaux de Moura, Ivan Roberto Bonotto Orso, Bruno da Costa Martins, Guilherme Sauniti Lopes, Somayeh Hosseinpour- Niazi, Parvin Mirmiran, Fereidoun Azizi, Maaike Kockx, Leonard Kritharides, Edward Loane, Vikram Jairam, Koji Uchida, Vasanthy Narayanaswami, Mohammad Z. Ashraf, Swati Srivastava, Ivana Pejin-Grubiša, Andriy L. Zagayko, Anna B. Kravchenko, Mykhaylo V. Voloshchenko, Oxana A. Krasilnikova, Amany M. M. Basuny, Isaac Karimi, Masashi Shiomi, Tomonari Koike, Tatsuro Ishida, Armando Sena, Carlos Capela, Camila Nóbrega, Véronique Férret-Sena, Elisa Campos, Rui Pedrosa, Sanja Stankovic, Milika Asanin, Nada Majkic-Singh, Etsuro Matsubara, Caryl J. Antalis, Kimberly K. Buhman, Adebowale Bernard Saba, Temitayo Ajibade, Vladana Vukojević, Ludmilla A. Morozova-Roche, Dalibor Novotný, Helena Vaverková, David Karásek, Yoshio Aizawa, Hiroshi Abe, Kai Yoshizawa, Haruya Ishiguro, Yuta Aida, Noritomo Shimada, Akihito Tsubota, Haruhiko Sakamoto, Masaki Ueno, Wu Bin, Yumiko Nagai, Kouichi Matsumoto, Takao Yamanaka, Sumiko Tanaka, Anna Gries Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Vedran Greblo Typesetting InTech Prepress, Novi Sad Cover InTech Design Team First published September, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Lipoproteins – Role in Health and Diseases, Edited by Saša Frank and Gerhard Kostner p. cm. ISBN 978-953-51-0773-6 Contents Preface XI Section 1 Lipoprotein Structure and Assembly 1 Chapter 1 Lipoprotein Structure and Dynamics: Low Density Lipoprotein Viewed as a Highly Dynamic and Flexible Nanoparticle 3 Ruth Prassl and Peter Laggner Chapter 2 New Insights into the Assembly and Metabolism of ApoB-Containing Lipoproteins from in vivo Kinetic Studies: Results on Healthy Subjects and Patients with Chronic Kidney Disease 21 Benjamin Dieplinger and Hans Dieplinger Section 2 Diagnosis of Lipoprotein Disorders 45 Chapter 3 The Importance of Lipid and Lipoprote in Ratios in Interpretetions of Hyperlipidaemia of Pregnancy 47 D.S. Mshelia and A.A. Kullima Chapter 4 A Non-Atherogenic and Atherogenic Lipoprotein Profile in Individuals with Dyslipoproteinemia 73 Stanislav Oravec, Johannes Mikl, Kristina Gruber and Elisabeth Dostal Chapter 5 The apoB/apoA-I Ratio is a Strong Predictor of Cardiovascular Risk 95 Göran Walldius Chapter 6 Approaches to Access Biological Data Sources 149 Assia Rharbi, Khadija Amine, Zohra Bakkoury, Afaf Mikou, Anass Kettani andAbdelkader Betari VI Contents Section 3 Hyper- and Dyslipoproteinemias 171 Chapter 7 Lipoproteins Impact Increasing Cardiovascular Mortality 173 Jelena Umbrasiene, Ruta-Marija Babarskiene and Jone Vencloviene Chapter 8 Lipoproteins and Cardiovascular Diseases 197 Adebowale Saba and Olayinka Oridupa Chapter 9 Linking the Pathobiology of Hypercholesterolemia with the Neutrophil Mechanotransduction 223 Xiaoyan Zhang and Hainsworth Y. Shin Section 4 Management of Hyper and Dyslipoproteinemias 253 Chapter 10 The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes 255 Summer F. Acevedo Chapter 11 Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent 269 Karl-Erik Eilertsen, Rune Larsen, Hanne K. Mæhre, Ida-Johanne Jensen and Edel O. Elvevoll Chapter 12 Endoscopic Treatment of Metabolic Syndrome 289 Eduardo Guimarães Hourneaux de Moura, Ivan Roberto Bonotto Orso, Bruno da Costa Martins and Guilherme Sauniti Lopes Chapter 13 Nutritional Management of Disturbances in Lipoprotein Concentrations 303 Somayeh Hosseinpour-Niazi, Parvin Mirmiran and Fereidoun Azizi Chapter 14 Cyclosporin A-Induced Hyperlipidemia 337 Maaike Kockx and Leonard Kritharides Chapter 15 Lipoproteins and Apolipoproteins of the Ageing Eye 355 Edward Loane Section 5 Lipid Oxidation and Anti-Oxidants 381 Chapter 16 Pathophysiology of Lipoprotein Oxidation 383 Vikram Jairam, Koji Uchida and Vasanthy Narayanaswami Chapter 17 Oxidized Phospholipids: Introduction and Biological Significance 409 Mohammad Z. Ashraf and Swati Srivastava Contents VII Chapter 18 HDL-Associated Paraoxonase 1 Gene Polymorphisms as a Genetic Markers for Wide Spread Diseases 431 Ivana Pejin-Grubiša Chapter 19 Antioxidant Complexes and Lipoprotein Metabolism – Experience of Grape Extracts Application Under Metabolic Syndrome and Neurogenic Stress 445 Andriy L. Zagayko, Anna B. Kravchenko, Mykhaylo V. Voloshchenko and Oxana A. Krasilnikova Chapter 20 The Anti-Atherogenic Effects of Lycopene 489 Amany M. M. Basuny Section 6 Animal Models for Lipoprotein Research 507 Chapter 21 Animal Models as Tools for Translational Research: Focus on Atherosclerosis, Metabolic Syndrome and Type-II Diabetes Mellitus 509 Isaac Karimi Chapter 22 Genetically Modified Animal Models for Lipoprotein Research 533 Masashi Shiomi, Tomonari Koike and Tatsuro Ishida Section 7 Role of Lipoproteins in Neurodegenerative Diseases 561 Chapter 23 Plasma Lipoproteins in Brain Inflammatory and Neurodegenerative Diseases 563 Armando Sena, Carlos Capela, Camila Nóbrega, Véronique Férret-Sena, Elisa Campos and Rui Pedrosa Chapter 24 Genetics of Ischemic Stroke: Emphasis on Candidate-Gene Association Studies 583 Sanja Stankovic, Milika Asanin and Nada Majkic-Singh Chapter 25 Lipoproteins and Apolipoproteins in Alzheimer's Disease 613 Etsuro Matsubara Section 8 Lipoproteins and Cancer 621 Chapter 26 Lipoproteins and Cancer 623 Caryl J. Antalis and Kimberly K. Buhman Chapter 27 Role of Lipoproteins in Carcinogenesis and in Chemoprevention 647 Adebowale Bernard Saba and Temitayo Ajibade VIII Contents Chapter 28 Structural Origin of ELOA Toxicity – Implication for HAMLET-Type Protein Complexes with Oleic Acid 663 Vladana Vukojević and Ludmilla A. Morozova-Roche Section 9 Lipoproteins in Inflammatory and Infectious Diseases 675 Chapter 29 Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial 677 Dalibor Novotný, Helena Vaverková and David Karásek Chapter 30 Dyslipoproteinemia in Chronic HCV Infection 701 Yoshio Aizawa, Hiroshi Abe, Kai Yoshizawa, Haruya Ishiguro, Yuta Aida, Noritomo Shimada and Akihito Tsubota Section 10 Lipoproteins and Hemostasis 719 Chapter 31 An Apolipoprotein CIII-Derived Peptide, Hatktak, Activates Macromolecular Activators of Phagocytosis from Platelets (MAPPs) 721 Haruhiko Sakamoto, Masaki Ueno, Wu Bin, Yumiko Nagai, Kouichi Matsumoto, Takao Yamanaka and Sumiko Tanaka Chapter 32 Lipoprotein (a) – An Overview 741 Anna Gries . LIPOPROTEINS – ROLE IN HEALTH AND DISEASES Edited by Saša Frank and Gerhard Kostner Lipoproteins – Role in Health and Diseases http://dx.doi.org/10.5772/2931. obtained from orders@intechopen.com Lipoproteins – Role in Health and Diseases, Edited by Saša Frank and Gerhard Kostner p. cm. ISBN 978-953-51-0773-6