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GS TS VÕ THÀNH NHÂN ĐH Y Dược – BV Chợ Rẫy TPHCM Millions Hypertension World Prevalence 2000 2025 Diagnosis % of Diagnosed BP Controlled Intermediate “Aiming” Targets Protecting the Patient from Cardiovascular Events Stable Angina Cerebral Infarction Myocardial Infarction Sudden Death factor) This imbalance contributes to progression of hypertension and associated cardiovascular risk In the newly diagnosed individual with hypertension, whether young or old, the vascular Effective Treatment of Coronary Artery Disease Fox KM et al EUROPA Trial Lancet 2003 Sep 6;362(9386):782-8 Prevention of Vascular Changes in Hypertension Collagen Fibres Effective Treatment of Hypertension Change in Mean Brachial Blood Pressure (mmHg) Effective Treatment of Hypertension Brachial SBP Arm Central SBP Brain Heart Kidney Williams B et al CAFÉ Study Circulation 2006; 113:1213-25 Effective Treatment of Hypertension Dahlof B et al ASCOT-BPLA Study Lancet 2005; 46:895-906 Which combination? Which combination is the best? “Which combination is best ?” Vs Winning Combinations Losing Combinations Never played e.g “Which combination is best ?” EURO 2016– Man of the Match / Golden Ball ADVANCE trial- CCB Analysis ADHERENCE > BP LOWERING > CARDIOVASCULAR PROTECTION