Neuro-Ophthalmology - Neurologic Clinics pdf

[...].. .Neuro-Ophthalmology Preface Andrew G Lee, MD Paul W Brazis, MD Guest Editors Neuro-ophthalmology is a subspecialty of neurology and ophthalmology that bridges the gap between eye and brain This issue of Neurologic Clinics describes the key features and latest information on topics in neuro-ophthalmology of interest to practicing neurologists and,... Factor-a Blocking Agents Granulomatous inflammation is typical of GCA and tumor necrosis factor-a (TNF-a) is important in the formation of granulomata.65 Therefore, it could be expected that anti-TNF-a therapies potentially hold promise as adjunctive agents; however, current data does not provide much support for their role in the treatment of GCA (Hoffman 2007) The successful use of anti-TNF-a agents... University of Iowa, Veterans Administration Medical Center, Iowa City, IA 52242 E-mail address: michael-wall@uiowa.edu Neurol Clin 28 (2010) 593–617 doi:10.1016/j.ncl.2010.03.003 neurologic. theclinics.com 073 3-8 619/10/$ – see front matter ª 2010 Elsevier Inc All rights reserved 594 Wall Fig 1 Magnetic resonance venogram showing smooth-walled venous stenoses of the transverse sinus, characteristic of IIH diplopia... TX 77030, USA Neurol Clin 28 (2010) xiii–xiv doi:10.1016/j.ncl.2010.05.001 neurologic. theclinics.com 073 3-8 619/10/$ – see front matter ª 2010 Elsevier Inc All rights reserved xiv Preface Paul W Brazis, MD Departments of Ophthalmology and Neurology Mayo Clinic - Jacksonville 4500 San Pablo Road Jacksonville, FL 32224, USA E-mail addresses: AGLee@tmhs.org (A.G Lee) Brazis.Paul@mayo.edu (P.W Brazis)... etanercept in a small group of patients with GCA suggests that this may be a useful steroid-sparing agent, with more steroid discontinuation, and fewer relapses.69 Further studies with larger groups of patients are needed to demonstrate the efficacy of anti-TNF-a agents in the treatment of GCA B-cell Depletion Rituximab, an anti-CD 20 monoclonal antibody that depletes B cells, has been used in one patient with... Ophthalmology 1986;93:518–30 9 Caselli RJ, Hunder GG, Whisnant JP Neurologic disease in biopsy-proven giant cell (temporal) arteritis Neurology 1988;38:352–9 10 Pfadenhauer K, Roesler A, Golling A The involvement of the peripheral nervous system in biopsy-proven active giant cell arteritis J Neurol 2007;254:751–5 11 Gonzales-Gay MA, Blanco R, Rodriguez-Valverdere V, et al Permanent visual loss and cerebrovascular... monotherapy for giant cell arteritis Ann Rheum Dis 2003;62:1116 68 Hoffman GS, Cic MC, Rendt-Zagar KE, et al infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial Ann Intern Med 2007;146:621–30 69 Martinez-Taboada VM, Rodriguez-Valverde V, Carreno L, et al A double-blind placebo controlled trial of etanercept in patients with giant cell arteritis and... value of fluorine-18-fluorodeoxyglucose position emission tomography (FDG-PET) for the diagnosis and monitoring of 35 patients with GCA.52 Vascular FDG uptake was noted in 83% of patients with biopsy-proven GCA, especially at the subclavian arteries (74%), but also in the thoracic and abdominal aorta (>50%) Vascular FDG uptake is a sensitive marker for large vessel vasculitis However, FDG-PET has a very... and Ophthalmology, Michigan State University, A217 Clinical Center, 138 Service Road, East Lansing, MI 48824, USA * Corresponding author E-mail address: david.clark@hc.msu.edu Neurol Clin 28 (2010) 573–580 doi:10.1016/j.ncl.2010.03.001 neurologic. theclinics.com 073 3-8 619/10/$ – see front matter ª 2010 Elsevier Inc All rights reserved 574 Clark et al a female to male ratio of approximately 3:1, with... account the risks and benefits as well as the side-effect profile, level of visual impairment, and the results of the MRI scan on an individualized, case-by-case basis LONG-TERM TREATMENT Optic neuritis may be the presenting symptom of MS The Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study (CHAMPS) evaluated patients Optic Neuritis with clinically isolated syndrome (CIS) or first . xiii–xiv doi:10.1016/j.ncl.2010.05.001 neurologic. theclinics.com 073 3-8 619/10/$ – see front matter ª 2010 Elsevier Inc. All rights reserved. Neuro-Ophthalmology Paul W Editors Neuro-ophthalmology is a subspecialty of neurology and ophthalmology that bridges the gap between eye and brain. This issue of Neurologic Clinics