Using trends and scenrios as tools for strategy development

... domain of each subunit contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and ... development of selective drugs is the identification and pharmacological characterization of the various receptor subtypes, and the determination of their precise subunit composition and physiological function( s) ... targets the a/d interface of the mammalian muscle nAChR and is the only ligand selective for the Torpedo a/d interface [33] (Fig 2A) However, information on the activity of EI at neuronal subtypes...

... with lupus disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated by the SLEDAI and the Systemic ... B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time Lupus 2006, 15:570-576 Ju S, Zhang D, Wang Y, ... activity biomarkers: value for drug development The pharmaceutical industry realized the unmet medical need for new therapeutics in lupus and has made a considerable investment in bringing new candidates...

... complex formation Labelling of the pY2m plasmid was never observed (data not shown) Labelling of pY1m was observed with a much lower yield than for pY (Fig 4) The labelling ratio between the two plasmids ... 0.25 °CÆmin)1 was therefore preferred for subsequent experiments with GT TFOs Padlock formation with TC oligonucleotides The use of TC TFOs has not been previously described for the formation of ... denaturation of the double-stranded DNA (B) 5344 formation of these structures may be used for the purpose of grafting ligands to double-stranded DNA [12] or for visualizing short double-stranded...

... insertion of the sample into the UHV chamber in spite of the preceding HF-dip There are hints in the literature [11 ] that deposition of gold onto a thin layer of SiO2 on Si (1 1) favors the decomposition ... melting point (15 7 1C) [13 ] As the surface tension of most liquids decreases in a nearly linear fashion with increasing temperature [14 ], there is a wide difference between the surface tension of ... tension tend to wet the substrate This could explain the formation of smaller droplets in the case of gold than in the case of indium on a bare silicon surface, i.e after desorption step for indium...