animal models as tools for translational research focus on atherosclerosis metabolic syndrome
Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... arthritis is considered to be non-erosive, although erosions may appear in late stages of the disease Inflammation and erosion of cartilage in the nasal septum is common and occasionally results ... found as manifestations from chondritis at specific sites As for many other autoimmune diseases, there have been reports of a correlation between RP diagnosis and the MHC class II region [6,7] ... Available online http://arthritis -research. com/content/4/5/296 Figure such as the skin and cardiovascular system are commonly affected by inflammation as well, the latter accounting for a fatal...
- 6
- 264
- 0
Tài liệu 50 Software Tools for Speech Research and Development doc
... general but easier to use 50.6.1 Text-Based Interfaces Traditional interfaces for specifying computations are based on a textual-representation in the form of scripts and programs For OS-based speech ... Software Tools for Speech Research and Development 50.1 Introduction 50.2 Historical Highlights 50.3 The User’s Environment (OS-Based vs Workspace-Based) Operating-System-Based Environment Environment ... In a visual interface for compute-oriented software, on the other hand, the focus is on the operations Operations among signals typically are represented as icons with one or more input and output...
- 13
- 412
- 0
Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... systems such as slices) and methodological variations (e.g different agonist concentrations, protocols for toxin application or determination of the toxin concentration) have to be considered 2308 ... 271) Identification and characterization of neuronally active a-conotoxins Assay-based and cDNA-based strategies The first a-conotoxins were identified using bioassays such as intraperitoneal (neuromuscular ... compared to conventional venom fractionation is that only small amounts of tissue are required In addition, conotoxins with low expression levels that would escape detection in functional assays can...
- 15
- 757
- 0
Tài liệu Báo cáo khoa học: Stem–loop oligonucleotides as tools for labelling double-stranded DNA pdf
... [10] For example, we showed that such a padlock oligonucleotide strongly inhibits DNA digestion by a restriction endonuclease, and that the complex is strong enough to inhibit the elongation of ... contain many Gs Moreover, as the triple helix was not stable in the absence of intercalator, it was possible to switch easily from conditions where the triple helix was very stable to conditions ... structures were formed only if the samples were heated before the ligation reaction was started Our idea was that the stem could dissociate upon heating, thereby allowing triple-helix formation between...
- 10
- 371
- 0
Báo cáo khoa học: "Hybrid Parsing: Using Probabilistic Models as Predictors for a Symbolic Parser" docx
... error propagation Whenever one component decides on the input of another, the subsequent one will most probably fail whenever the decision was wrong; if not, the erroneous information was not crucial ... integration does not blindly rely on the available predictions but is able to question them as long as there is strong enough combined evidence from the grammar and the other predictor components For ... compensate for the last two effects we re-evaluated our parser without considering punctuation but providing it with perfect POS tags Thus, under similar conditions as used for the CoNLL evaluation we...
- 8
- 271
- 0
Báo cáo sinh học: " Medical education and research environment in Qatar: a new epoch for translational research in the Middle East" pptx
... Organization; 2002 Background Paper: Non Communicable Diseases in Low and Middle Income Countries Regional High-level Consultation in the Eastern Mediterranean Region on the Prevention and Control ... interwoven framework of education, research, public health and clinical components lays a sturdy foundation for developing evidence based translational research as discussed in this review We ... interwoven education, research and public health based framework provides a robust platform for translational medicine research programs Chouchane et al Journal of Translational Medicine 2011,...
- 8
- 375
- 0
báo cáo hóa học:" Medical education and research environment in Qatar: a new epoch for translational research in the Middle East" doc
... Organization; 2002 Background Paper: Non Communicable Diseases in Low and Middle Income Countries Regional High-level Consultation in the Eastern Mediterranean Region on the Prevention and Control ... interwoven framework of education, research, public health and clinical components lays a sturdy foundation for developing evidence based translational research as discussed in this review We ... interwoven education, research and public health based framework provides a robust platform for translational medicine research programs Chouchane et al Journal of Translational Medicine 2011,...
- 8
- 494
- 0
Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
... studies into the association of sCD25 with lupus disease activity strongly support the inclusion of this protein as part of a biomarker panel As with the measurement of complement activation, however, ... previously identified as a biomarker for lupus Available online http://arthritis -research. com/content/11/6/255 disease activity [34], was also demonstrated to be elevated on peripheral T cells ... expansion of a unique population of CD19+/CD27high plasma cells was noted under the condition of lupus Jacobi and colleagues evaluated the correlation of CD27high plasma cells and disease activity...
- 7
- 387
- 0
báo cáo hóa học:" Research Article HIFSuite: Tools for HDL Code Conversion and Manipulation" ppt
... based on an intermediate format, and they target only a point-to-point translation from one HDL to another HDL or C++ Thus, manipulation on the code before the translation is not supported On ... semantics such tools rely on 5.1 The Front-End and Back-End Conversion Tools The conversion tools are organized into front-end (HDL2HIF) and back-end (HIF2HDL) tool sets 5.1.1 HDL2HIF They convert HDL ... corresponding to traditional HDL constructs like, for example, processes, variable/signal declarations, sequential and concurrent statements, and so forth (see Section 4) (ii) Second is a set of front/back-end...
- 20
- 449
- 0
báo cáo hóa học:" Research Article Data Cache-Energy and Throughput Models: Design Exploration for Embedded Processors" doc
... Iteration simulated energy consumption was obtained by multiplying per cycle energy consumption as per datasheet specification, by the number of cycles executed in the target application The results ... approach for energy and throughput for an application basis In fact the accuracy of these models is independent of any particular cache configuration as standard cache energy and timing tools are ... misses is not accounted for a particular application Apart from the mathematical models, substantial work has been done for cache miss rate prediction and minimization Ding and Zhong in [18] have presented...
- 7
- 286
- 0
Báo cáo hóa học: " Research Article Experimental Evaluation of the Usage of Ad Hoc Networks as Stubs for Multiservice Networks" ppt
... an integration level adequate for controlled trials However, even considering this as research prototype software, the large number of interactions identified has raised some concerns on the development ... also obtained for delay and jitter, as well as for autoconfiguration only Based on these results, we decided to use the indoor topology to run the remaining tests 5.4 QoS In this section, we summarize ... hop way from the receiver, which we denote as the last forwarding node, is responsible for sending the proofs to the gateway, which contain information on the path(s) of the flow When receiving...
- 14
- 332
- 0
Báo cáo hóa học: " Research Article On the Utility of Syllable-Based Acoustic Models for Pronunciation Variation Modelling" pptx
... multiple pronunciation lexicon, Hain [25] focused on finding a single optimal phonetic transcription for each word in the lexicon Our study confirms that a single pronunciation that is consistently ... performance of the triphone recogniser determined the baseline performance for each recognition task 3.3.1 Triphone recogniser A standard procedure with decision tree state tying was used for ... syllable models, the gains from including longerlength acoustic models were small and depended heavily on the recognition task: for telephone numbers, the performance even decreased In any case,...
- 11
- 392
- 0
Báo cáo hóa học: " Research Article Tools for Protecting the Privacy of Specific Individuals in Video" potx
... detection and bidirectional tracking, which is discussed in Section The training data for constructing a person identification system can be labeled from two different modules One is the conventional ... track a face using an approach based on online region confidence learning This approach associates different local regions of a face with different confidences on the basis of their discriminative powers ... pairwise constraints for video object classification,” in Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR ’04), vol 2, pp 284–293, Washington, DC,...
- 9
- 332
- 0
Báo cáo lâm nghiệp: "New insights in the recognition of the European ash species Fraxinus excelsior L. and Fraxinus angustifolia Vahl as useful tools for forest management" pdf
... were performed using the BLAST algorithm at http://www.ncbi.nlm.nih.gov (National Center for Biotechnology Information), with programs blastn, tblastn and tblastx New primers were redefined on the ... contingency table was performed on the phenotypic composition of each population using procedure CORRESP in SAS (SAS Institute, Cary, NC, USA) 2.2 Seed characteristics Seeds were harvested on ... their colonizing abilities (see [9] for F excelsior) This can be useful for studies of hybridization in zones of sympatry and/or of putative replacement of common ash by narrowleaved ash, for example...
- 6
- 521
- 0
Báo cáo y học: "The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis" ppsx
... factors The disease models should therefore preferably be correspondingly polygenic and dependent on environment There are a number of available animal models for RA that all mimic various aspects of ... animals is dependent on there being good models of human diseases In this review we focus on RA, a highly heterogeneous autoimmune disease that is known to depend on multiple genes and environmental ... proven; as for candidate studies, this type of reasoning is counter to one of the main aims: hypothesis-free generation of new knowledge Interestingly, C5 has already been implicated, based on studies...
- 10
- 416
- 0
Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... transgene expression, both under control of the tetO promoter in a head–tail configuration on one plasmid The plasmid was electrotransferred intramuscularly in order to yield expression of a dimeric ... cause p53 mutations that transform cells resulting in aberrant proliferation [76] Mutated p53 is considered responsible for the transformation of synovial fibroblasts into invasive phenotypes ... DBA1/J mice before the onset of CIA dramatically reduced pannus formation (invasive tissue of fibroblast-like cells in cartilage and bone) and cartilage erosion as a result of the prevention of angiogenesis...
- 14
- 578
- 0
Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... motivation was a case when a trait Yl was measured on males and y was measured on females and there was interest in the genetic covariance between traits (0’ ) A12 and there was no environmental ... selection in univariate and multivariate settings (for example, Henderson et al, 1959; Thompson, 1973) if the records on which selection is based are included in the data If this condition is only ... effects Secondly, in order that , scaled versions of Yl and y have homogeneous contributions for e and e as in l , model 1, but also for Ub scaling factors, a and b for the contributions of Ub...
- 10
- 317
- 0
Báo cáo sinh học: " Prediction of breeding values with additive animal models for crosses from 2 populations" ppt
... evaluations for such a mixture of crossbred animals can be obtained by BLUP using Henderson’s = = mixed-model equations (MME) Genetic evaluations are based on a vector of be modelled as: (1984) ... Henderson’s MME, can be constructed was as: where G, is a diagonal matrix with the ith Note that these elements are diagonal linear functions of element defined a2 and as: !ALI! PREDICTION OF ... Linear Regression Analysis J Wiley & Sons, New York, USA Thompson R (1979) Sire evaluation Biometrics 35, 339-353 Toutenburg H (1982) Prior Information on Linear Models J Wiley & Sons, New York,...
- 12
- 311
- 0
Báo cáo sinh học: "Inequality of maximum a posteriori estimators with equivalent sire and animal models for threshold traits" pps
... truncation selection Meijering and Gianola (1985) showed that with a balanced random one-way classification and binary responses, the application of quasi-best linear unbiased prediction (QBLUP) ... European Association for Animal Production Edinburgh, 5-8 September 1994 Meijering A, Gianola D (1985) Liner versus nonlinear methods of sire evaluation for categorical traits: a simulation study ... posteriori estimation procedure, was employed to demonstrate the differences between the estimators based on either a sire or an animal model The data consist of calving ease scores from 28 male...
- 13
- 302
- 0
Báo cáo sinh học: "Restricted maximum likelihood estimation for animal models using derivatives of the likelihood" pptx
... used only in conjunction with optimisation techniques ensuring an increase in log G in each iteration Further motivation for the scope to reduce use of transformations has been computational effort ... 2possible = combinations of traits recorded (assuming single records per trait), eg, W for with combinations trait only, trait only and both traits For animal i q which has combination of traits w, ... calculation of second derivatives by backward differentiation (pseudo-code not shown here) Amongst other calculations, this involves one evaluation of a matrix W as described above, for each...
- 27
- 266
- 0
Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25