... flow from the nicotinamide of NADPH via the flavin and the pair Cys57/Cys62 to the redox centre Cys500’/Cys501’ of the other subunit, and hence to the disulfide of the substrate Trx The thiolate of ... malaria system, i.e that in the parasite, the human host, and the insect vector Isolation of A gambiae TrxR from insect cells From mL of pelleted A gambiae cells, 19 U of A gambiae TrxR activity was ... parentheses) with the enzymes from Anopheles gambiae (AgTrxR-1, CAD30858), Drosophila melanogaster (DmTrxR-1, AAG25639), humans (hTrxR, AAB35418), and from the malaria parasite Plasmodium falciparum...