Báo cáo khoa học: "Recent evolution of renal replacement therapy in the critically ill patient" pptx

... therapy of the critically ill patient with renal and other organ dysfunction is given in Fig. 2. The last generation of machines available on the market today and representing the evolution of ... hemofiltration, or the combined use of adsorbent techniques in systems where the CommentaryRecent evolution of renal replacement therapy in the critically ill patientClaudio RoncoDepartment of ... the evolution of the pastdecade of research and development is shown in Fig. 3.Two interesting aspects of the evolution of renal replacement therapy (RRT) in the ICU over the past decade arerepresented...

báo cáo khoa học: "Recent advances of novel targeted therapy in non-small cell lung cancer" pot

... spurred the develop-ment of more than 500 novel therapies. In the process of identifying targets for therapy, our understanding of the molecular pathways involved in malignancy has alsoincreased. ... [133]. There is a phase II and a phase III trialunderway evaluating the combination of erlotinib with orwithout sunitinib. In addition, the combinations of sunitinib with other chemotherapeutic ... in the activation of EGFR-dependent intracellular signaling. First, the binding of a receptor-specific ligand occurs in the extracellular portion of the EGFR or of one of the EGFR-related receptors...

Báo cáo khoa học: "Diagnostic ability of hand-held echocardiography in ventilated critically ill patients" docx

... are intensivists with level 3 training in echocardiography [15]. They were not aware of the findingsyielded by the alternative imaging modality, but both investi-gators were provided with the ... and in 13 of themduring the conventional TTE examination. Examples of two-dimensional and color Doppler still frames obtained using the portable system are shown in Figs 2 and 3. The mean time ... extending the physicalexamination and potentially improving patient care[6,7,18,19]. The efficacy and safety of tailored ultrasoundtraining to specific needs remains to be tested using HHE in the...

Báo cáo khoa học: "Molecular evolution of measles viruses circulated in Taiwan 1992-2008" doc

... highlighting the sequences in genotype H1Figure 3Phylogenetic analysis of the 456 nts coding for the COOH terminus of the N protein of measles viruses detected in Taiwan, 1992-2008, highlighting the ... so the exact distribution of the clade H viruses in the pre-vaccine era is unknown.This report contains the first analysis of the genetic char-acteristics of MeVs circulating in Taiwan over the ... countries of Indonesia, Malaysia, Philippines, Thai-land, and Vietnam in the beginning of 1989. The number of foreign workers reached 330,000 by end of 2006,accounting for 1.4% of the total...

Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt

... cDNAsequences using the RACE method in both strainsrevealed the presence of a single point mutation in 1337 nucleotides of BmIVD. In the sku mutant, the 1127th guanine from the start codon was ... acts in the third step of leucine degradation and the sku mutant accumulates branched-chain amino acids in haemolymph, thismutant may be useful in the investigation of unique branched-chain aminoacid ... surface of the monomer, pointing toward FAD or its neigh-bouring monomer in the tetramer. By contrast, the side chain of the mutated residue (Val376) pointstoward the inside of the helix–loop–helix...

Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf

... chemokines stimu-lated mainly by in ammatory cytokines, including IL-1b, TNF-a andIFN-c. (B) Chemokines expressed in the joint recruit leukocytes into the joints. In addition to functioning in ... regulated mainly by TNF-a. The role of chemokines in RA pathogenesis The chemokines listed above are implicated in RApathogenesis via the recruitment and retention of leu-kocytes in the joints. In addition ... subclasses include the CC chemokines(where the cysteines are neighboring) and the CXCchemokines (where the cysteines are separated by oneamino acid). The CXC chemokines mainly act on neu-trophils...

Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

... dependence of the pH-activity curve of API The pH-activity proﬁles depending on NaCl concentrationwere determined as part of the investigation into the shielding from solvent of the electrostatic interactionbetween ... position. In the struc-tural deviation, the solvent ASA of the side-chain of His210increased with the decrease in size of the side-chain atresidue 169 (Table 1 and Fig. 3A). However, the ASAs of Asp113 ... size of the side-chain at residue 169 and the pK2showed a clear linear relationship (Fig. 3B). The pK2increased as the size of the residue at position 169 increased. The effect of the size of...

Báo cáo khoa học: Identiﬁcation of tyrosine-phosphorylation sites in the nuclear membrane protein emerin pot

... attachedto the lamina by integral membrane proteins of the INM. The INM proteins form complexes, transientlyor stably, with lamins, chromatin proteins and a vari-ety of regulatory proteins, including ... improving the search for phosphopeptidescontaining phosphotyrosine, we identiﬁed one of the well-deﬁned integral INM proteins. Emerin is a type-IIintegral membrane protein of 34 kDa, which is inser-ted ... phosphotyrosineimmunosignal may be misleading, since the afﬁnity of phosphotyrosine-speciﬁc antibodies is always in u-enced by amino acid residues surrounding the phos-photyrosine. Finally, emerin in...

Báo cáo khoa học: Conformational stability of 17b-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus pptx

... data thus show that the absence of induction of thermal stability by NADPHbinding is the consequence of enthalpic compensation of the disturbed intramolecular interactions by the newly formed electrostatic ... states of the protein. In the pH range from neutral to 2.0, therewas a transition into an acid-denatured state, and afurther decrease in pH from 2.0 to 1.0 induced anincrease in the amount of ... basic residues that interact electrostatically with the ribose 2¢-phosphate group of the adenine nucleo-tide of NADPH. One of these interacts with the sec-ond glycine in the Gly-X-X-X-Gly-X-Gly...

Báo cáo khoa học: Membrane binding of SRP pathway components in the halophilic archaea Haloferax volcanii docx

... beenreported that in addition to the cluster of positive chargesfound at the start of the N-terminal FtsY A domain, asecond region contained within the NG domain of the protein participates in FtsY membrane ... encodingfor a C-terminally polyhistidine-tagged version of the protein. Given that the presence of a His6-tag at the C-terminus of the E. coli FtsY NG domain did notinterfere with determination ... unexpected, having been previ-ously reported in the case of E. coli FtsY [11] andattributed to the amino acid composition of the acidicdomain (A domain) of the protein [25,34]. Moreover, the aberrant...

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